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    TRPM8 transient receptor potential cation channel subfamily M member 8 [ Homo sapiens (human) ]

    Gene ID: 79054, updated on 27-Aug-2016
    Official Symbol
    TRPM8provided by HGNC
    Official Full Name
    transient receptor potential cation channel subfamily M member 8provided by HGNC
    Primary source
    HGNC:HGNC:17961
    See related
    Ensembl:ENSG00000144481 HPRD:09454; MIM:606678; Vega:OTTHUMG00000059129
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TRPP8; LTRPC6
    Orthologs
    Location:
    2q37.1
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 2 NC_000002.12 (233917342..234019522)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (234826043..234928166)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene Holliday junction recognition protein Neighboring gene male-specific lethal 3 homolog (Drosophila) pseudogene 1 Neighboring gene secreted phosphoprotein 2 Neighboring gene uncharacterized LOC105373932

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    NHGRI GWAS Catalog

    Description
    A genome-wide association study of behavioral disinhibition.
    NHGRI GWA Catalog
    Genome-wide association analysis identifies susceptibility loci for migraine without aura.
    NHGRI GWA Catalog
    Genome-wide association study combining pathway analysis for typical sporadic amyotrophic lateral sclerosis in Chinese Han populations.
    NHGRI GWA Catalog
    Genome-wide association study identifies 8 novel loci associated with blood pressure responses to interventions in Han Chinese.
    NHGRI GWA Catalog
    Genome-wide association study reveals three susceptibility loci for common migraine in the general population.
    NHGRI GWA Catalog
    Genome-wide meta-analysis identifies new susceptibility loci for migraine.
    NHGRI GWA Catalog
    • Inflammatory mediator regulation of TRP channels, organism-specific biosystem (from KEGG)
      Inflammatory mediator regulation of TRP channels, organism-specific biosystemThe TRP channels that exhibit a unique response to temperature have been given the name thermo-TRPs. Among all thermo- TRP channels, TRPV1-4, TRPM8, and TRPA1 are expressed in subsets of nociceptive...
    • Inflammatory mediator regulation of TRP channels, conserved biosystem (from KEGG)
      Inflammatory mediator regulation of TRP channels, conserved biosystemThe TRP channels that exhibit a unique response to temperature have been given the name thermo-TRPs. Among all thermo- TRP channels, TRPV1-4, TRPM8, and TRPA1 are expressed in subsets of nociceptive...
    • Ion channel transport, organism-specific biosystem (from REACTOME)
      Ion channel transport, organism-specific biosystemIon channels mediate the flow of ions across the plasma membrane of cells. They are integral membrane proteins, typically a multimer of proteins, which, when arranged in the membrane, create a pore f...
    • Stimuli-sensing channels, organism-specific biosystem (from REACTOME)
      Stimuli-sensing channels, organism-specific biosystemIon channels that mediate sensations such as pain, warmth, cold, taste pressure and vision. Channels that mediate these sensations include acid-sensing ion channels (ASICs) (Wang & Xu 2011, Qadri et ...
    • TRP channels, organism-specific biosystem (from REACTOME)
      TRP channels, organism-specific biosystemTransient receptor potential (TRP) channel proteins were first discovered in Drosophila melanogaster and have many homologues in other species including humans. TRPs form cationic channels that can ...
    • Transmembrane transport of small molecules, organism-specific biosystem (from REACTOME)
      Transmembrane transport of small molecules, organism-specific biosystem
      Transmembrane transport of small molecules
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • MGC2849

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    calcium channel activity TAS
    Traceable Author Statement
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein homodimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    calcium ion transmembrane transport TAS
    Traceable Author Statement
    more info
     
    cellular calcium ion homeostasis IEA
    Inferred from Electronic Annotation
    more info
     
    detection of temperature stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    protein homotetramerization IEA
    Inferred from Electronic Annotation
    more info
     
    protein homotrimerization IEA
    Inferred from Electronic Annotation
    more info
     
    response to cold IEA
    Inferred from Electronic Annotation
    more info
     
    thermoception IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
     
    external side of plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    membrane raft IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane TAS
    Traceable Author Statement
    more info
     
    Preferred Names
    transient receptor potential cation channel subfamily M member 8
    Names
    LTrpC-6
    long transient receptor potential channel 6
    short form of the TRPM8 cationic channel
    transient receptor melastatin 8 variant 1
    transient receptor melastatin 8 variant 2
    transient receptor potential p8
    transient receptor potential subfamily M member 8
    trp-p8

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_024080.4NP_076985.4  transient receptor potential cation channel subfamily M member 8

      See identical proteins and their annotated locations for NP_076985.4

      Status: VALIDATED

      Source sequence(s)
      AC005538, AY090109, BC001135, BC033137
      Consensus CDS
      CCDS33407.1
      UniProtKB/Swiss-Prot
      Q7Z2W7
      UniProtKB/TrEMBL
      W8DTH1
      Related
      ENSP00000323926, OTTHUMP00000065206, ENST00000324695, OTTHUMT00000131005
      Conserved Domains (2) summary
      pfam00520
      Location:770978
      Ion_trans; Ion transport protein
      cl21495
      Location:693899
      Acyl_transf_3; Acyltransferase family

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p7 Primary Assembly

      Range
      233917342..234019522
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011511810.2XP_011510112.1  

      Conserved Domains (2) summary
      pfam00520
      Location:770978
      Ion_trans; Ion transport protein
      cl21495
      Location:693899
      Acyl_transf_3; Acyltransferase family
    2. XM_017004891.1XP_016860380.1  

    Alternate CHM1_1.1

    Genomic

    1. NC_018913.2 Alternate CHM1_1.1

      Range
      234831850..234933975
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)