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SMYD2 SET and MYND domain containing 2 [ Homo sapiens (human) ]

Gene ID: 56950, updated on 13-Jan-2015
Official Symbol
SMYD2provided by HGNC
Official Full Name
SET and MYND domain containing 2provided by HGNC
Primary source
HGNC:HGNC:20982
Locus tag
RP11-176D17.2
See related
Ensembl:ENSG00000143499; HPRD:15406; MIM:610663; Vega:OTTHUMG00000037066
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
KMT3C; HSKM-B; ZMYND14
Summary
SET domain-containing proteins, such as SMYD2, catalyze lysine methylation (Brown et al., 2006 [PubMed 16805913]).[supplied by OMIM, Nov 2008]
Orthologs
See SMYD2 in MapViewer
Location:
1q32.3
Exon count:
12
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 1 NC_000001.11 (214281222..214337134)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (214454565..214510477)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene PROX1 antisense RNA 1 Neighboring gene prospero homeobox 1 Neighboring gene uncharacterized LOC102723802 Neighboring gene protein tyrosine phosphatase, non-receptor type 14 Neighboring gene adaptor-related protein complex 3, sigma 1 subunit pseudogene Neighboring gene keratin 18 pseudogene 12

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.
NHGRI GWA Catalog
  • Chromatin modifying enzymes, organism-specific biosystem (from REACTOME)
    Chromatin modifying enzymes, organism-specific biosystemEukaryotic DNA is associated with histone proteins and organized into a complex nucleoprotein structure called chromatin. This structure decreases the accessibility of DNA but also helps to protect i...
  • Chromatin organization, organism-specific biosystem (from REACTOME)
    Chromatin organization, organism-specific biosystemChromatin organization refers to the composition and conformation of complexes between DNA, protein and RNA. It is determined by processes that result in the specification, formation or maintenance o...
  • PKMTs methylate histone lysines, organism-specific biosystem (from REACTOME)
    PKMTs methylate histone lysines, organism-specific biosystemProtein lysine methyltransferases (KMTs) and Protein arginine methytransferases (RMTs) have a common mechanism of catalysis. All transfer a methyl group from a common donor, S-adenosyl-L-methionine (...
  • p53 pathway, organism-specific biosystem (from Pathway Interaction Database)
    p53 pathway, organism-specific biosystem
    p53 pathway
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC119305

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA polymerase II core binding ISS
Inferred from Sequence or Structural Similarity
more info
 
histone methyltransferase activity (H3-K36 specific) ISS
Inferred from Sequence or Structural Similarity
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
p53 binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein-lysine N-methyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
chromatin organization TAS
Traceable Author Statement
more info
 
histone H3-K36 methylation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of transcription from RNA polymerase II promoter IMP
Inferred from Mutant Phenotype
more info
PubMed 
peptidyl-lysine dimethylation ISS
Inferred from Sequence or Structural Similarity
more info
 
peptidyl-lysine monomethylation IDA
Inferred from Direct Assay
more info
PubMed 
regulation of DNA damage response, signal transduction by p53 class mediator IMP
Inferred from Mutant Phenotype
more info
PubMed 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
cytosol ISS
Inferred from Sequence or Structural Similarity
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 
Preferred Names
N-lysine methyltransferase SMYD2
Names
N-lysine methyltransferase SMYD2
lysine N-methyltransferase 3C
histone methyltransferase SMYD2
zinc finger, MYND domain containing 14
SET and MYND domain-containing protein 2
NP_064582.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_020197.2NP_064582.2  N-lysine methyltransferase SMYD2

    See proteins identical to NP_064582.2

    Status: VALIDATED

    Source sequence(s)
    AW474469, BC098276, BG723585
    Consensus CDS
    CCDS31022.1
    UniProtKB/Swiss-Prot
    Q9NRG4
    Related
    ENSP00000355924, OTTHUMP00000035134, ENST00000366957, OTTHUMT00000089998
    Conserved Domains (3) summary
    pfam00856
    Location:184240
    SET; SET domain
    pfam01753
    Location:5290
    zf-MYND; MYND finger
    pfam13424
    Location:338413
    TPR_12; Tetratricopeptide repeat

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000001.11 

    Range
    214281222..214337134
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_426790.1 RNA Sequence

Alternate CHM1_1.1

Genomic

  1. NC_018912.2 

    Range
    215726941..215782851
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

  1. AC_000133.1 

    Range
    185129703..185185600
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)