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    PIAS4 protein inhibitor of activated STAT 4 [ Homo sapiens (human) ]

    Gene ID: 51588, updated on 20-Aug-2016
    Official Symbol
    PIAS4provided by HGNC
    Official Full Name
    protein inhibitor of activated STAT 4provided by HGNC
    Primary source
    HGNC:HGNC:17002
    See related
    Ensembl:ENSG00000105229 HPRD:06910; MIM:605989; Vega:OTTHUMG00000181759
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PIASY; Piasg; ZMIZ6; PIAS-gamma
    Orthologs
    Location:
    19p13.3
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 19 NC_000019.10 (4007598..4039386)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (4007749..4038067)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene death associated protein kinase 3 Neighboring gene microRNA 637 Neighboring gene small nucleolar RNA, C/D box 37 Neighboring gene eukaryotic translation elongation factor 2 Neighboring gene zinc finger and BTB domain containing 7A Neighboring gene mitogen-activated protein kinase kinase 2

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

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      Cell Cycle, organism-specific biosystem
      Cell Cycle
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      Cell Cycle Checkpoints, organism-specific biosystemA hallmark of the human cell cycle in normal somatic cells is its precision. This remarkable fidelity is achieved by a number of signal transduction pathways, known as checkpoints, which monitor cell...
    • Coregulation of Androgen receptor activity, organism-specific biosystem (from Pathway Interaction Database)
      Coregulation of Androgen receptor activity, organism-specific biosystem
      Coregulation of Androgen receptor activity
    • DNA Double Strand Break Response, organism-specific biosystem (from REACTOME)
      DNA Double Strand Break Response, organism-specific biosystemDNA double strand break (DSB) response involves sensing of DNA DSBs by the MRN complex which triggers ATM activation. ATM phosphorylates a number of proteins involved in DNA damage checkpoint signali...
    • DNA Double-Strand Break Repair, organism-specific biosystem (from REACTOME)
      DNA Double-Strand Break Repair, organism-specific biosystemNumerous types of DNA damage can occur within a cell due to the endogenous production of oxygen free radicals, normal alkylation reactions, or exposure to exogenous radiations and chemicals. Double-s...
    • DNA Repair, organism-specific biosystem (from REACTOME)
      DNA Repair, organism-specific biosystemDNA repair is a phenomenal multi-enzyme, multi-pathway system required to ensure the integrity of the cellular genome. Living organisms are constantly exposed to harmful metabolic by-products, enviro...
    • G2/M Checkpoints, organism-specific biosystem (from REACTOME)
      G2/M Checkpoints, organism-specific biosystemG2/M checkpoints include the checks for damaged DNA, unreplicated DNA, and checks that ensure that the genome is replicated once and only once per cell cycle. If cells pass these checkpoints, they f...
    • G2/M DNA damage checkpoint, organism-specific biosystem (from REACTOME)
      G2/M DNA damage checkpoint, organism-specific biosystemThroughout the cell cycle, the genome is constantly monitored for damage, resulting either from errors of replication, by-products of metabolism or through extrinsic sources such as ultra-violet or i...
    • HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA), organism-specific biosystem (from REACTOME)
      HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA), organism-specific biosystemHomology directed repair (HDR) of replication-independent DNA double strand breaks (DSBs) via homologous recombination repair (HRR) or single strand annealing (SSA) requires the activation of ATM fol...
    • Homology Directed Repair, organism-specific biosystem (from REACTOME)
      Homology Directed Repair, organism-specific biosystemHomology directed repair (HDR) of DNA double strand breaks (DSBs) requires resection of DNA DSB ends. Resection creates 3'-ssDNA overhangs which then anneal with a homologous DNA sequence. This homol...
    • IFN-gamma pathway, organism-specific biosystem (from Pathway Interaction Database)
      IFN-gamma pathway, organism-specific biosystem
      IFN-gamma pathway
    • Jak-STAT signaling pathway, organism-specific biosystem (from KEGG)
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    • Jak-STAT signaling pathway, conserved biosystem (from KEGG)
      Jak-STAT signaling pathway, conserved biosystemThe Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeost...
    • Metabolism of proteins, organism-specific biosystem (from REACTOME)
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    • Post-translational protein modification, organism-specific biosystem (from REACTOME)
      Post-translational protein modification, organism-specific biosystemAfter translation, many newly formed proteins undergo further covalent modifications that alter their functional properties and that are essentially irreversible under physiological conditions in the...
    • Processing of DNA double-strand break ends, organism-specific biosystem (from REACTOME)
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    • Regulation of nuclear SMAD2/3 signaling, organism-specific biosystem (from Pathway Interaction Database)
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    • SUMO E3 ligases SUMOylate target proteins, organism-specific biosystem (from REACTOME)
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    • Ubiquitin mediated proteolysis, organism-specific biosystem (from KEGG)
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    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • FLJ12419, MGC35296

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    SUMO ligase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    SUMO transferase activity EXP
    Inferred from Experiment
    more info
    PubMed 
    SUMO transferase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    SUMO transferase activity TAS
    Traceable Author Statement
    more info
     
    ligase activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein C-terminus binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    transcription corepressor activity IEA
    Inferred from Electronic Annotation
    more info
     
    ubiquitin protein ligase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    zinc ion binding NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    PML body IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nuclear matrix IEA
    Inferred from Electronic Annotation
    more info
     
    nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    nucleoplasm TAS
    Traceable Author Statement
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus NAS
    Non-traceable Author Statement
    more info
    PubMed 
    transferase complex IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    E3 SUMO-protein ligase PIAS4
    Names
    protein inhibitor of activated STAT protein 4
    protein inhibitor of activated STAT protein PIASy
    protein inhibitor of activated STAT protein gamma
    protein inhibitor of activated STAT, 4
    zinc finger, MIZ-type containing 6

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_015897.3NP_056981.2  E3 SUMO-protein ligase PIAS4

      See identical proteins and their annotated locations for NP_056981.2

      Status: VALIDATED

      Source sequence(s)
      AA758531, AK022481, BC029874, HY027695
      Consensus CDS
      CCDS12118.1
      UniProtKB/Swiss-Prot
      Q8N2W9
      UniProtKB/TrEMBL
      B3KMR4
      Related
      ENSP00000262971, OTTHUMP00000267409, ENST00000262971, OTTHUMT00000457496
      Conserved Domains (3) summary
      smart00513
      Location:1246
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      pfam02891
      Location:322371
      zf-MIZ; MIZ/SP-RING zinc finger
      pfam14324
      Location:131269
      PINIT; PINIT domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p7 Primary Assembly

      Range
      4007598..4039386
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011528060.2XP_011526362.1  

      Conserved Domains (3) summary
      pfam02891
      Location:341390
      zf-MIZ; MIZ/SP-RING zinc finger
      smart00513
      Location:3165
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      pfam14324
      Location:151296
      PINIT; PINIT domain
    2. XM_017026868.1XP_016882357.1  

    Alternate CHM1_1.1

    Genomic

    1. NC_018930.2 Alternate CHM1_1.1

      Range
      4007220..4038698
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_016149.1: Suppressed sequence

      Description
      NM_016149.1: This RefSeq was permanently suppressed because the CDS is partial.