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SIRT6 sirtuin 6 [ Homo sapiens (human) ]

Gene ID: 51548, updated on 11-Sep-2014
Official Symbol
SIRT6provided by HGNC
Official Full Name
sirtuin 6provided by HGNC
Primary source
HGNC:HGNC:14934
See related
Ensembl:ENSG00000077463; HPRD:12093; MIM:606211; Vega:OTTHUMG00000181847
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SIR2L6
Summary
This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class IV of the sirtuin family. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Jul 2010]
See SIRT6 in Epigenomics, MapViewer
Location:
19p13.3
Exon count:
8
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 19 NC_000019.10 (4174109..4182599, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (4174106..4182596, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene mitogen-activated protein kinase kinase 2 Neighboring gene cAMP responsive element binding protein 3-like 3 Neighboring gene ankyrin repeat domain 24 Neighboring gene Epstein-Barr virus induced 3

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
NAD(P)+-protein-arginine ADP-ribosyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
NAD+ ADP-ribosyltransferase activity TAS
Traceable Author Statement
more info
PubMed 
NAD+ binding ISS
Inferred from Sequence or Structural Similarity
more info
 
NAD-dependent histone deacetylase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
NAD-dependent histone deacetylase activity (H3-K9 specific) IDA
Inferred from Direct Assay
more info
PubMed 
chromatin binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
zinc ion binding ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
histone H3 deacetylation IDA
Inferred from Direct Assay
more info
PubMed 
histone deacetylation ISS
Inferred from Sequence or Structural Similarity
more info
 
protein ADP-ribosylation ISS
Inferred from Sequence or Structural Similarity
more info
 
protein ADP-ribosylation TAS
Traceable Author Statement
more info
PubMed 
regulation of double-strand break repair via homologous recombination IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
nuclear telomeric heterochromatin IDA
Inferred from Direct Assay
more info
PubMed 
NOT nucleolus IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 
Preferred Names
NAD-dependent protein deacetylase sirtuin-6
Names
NAD-dependent protein deacetylase sirtuin-6
sirtuin type 6
SIR2-like protein 6
sir2-related protein type 6
regulatory protein SIR2 homolog 6
NAD-dependent deacetylase sirtuin-6
NP_001180214.1
NP_057623.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001193285.1NP_001180214.1  NAD-dependent protein deacetylase sirtuin-6 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an exon in the coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AC006930, AC016586
    Consensus CDS
    CCDS54199.1
    UniProtKB/Swiss-Prot
    Q8N6T7
    Related
    ENSP00000305310, OTTHUMP00000267649, ENST00000305232, OTTHUMT00000457930
    Conserved Domains (1) summary
    cl00195
    Location:45230
    SIR2; SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, ...
  2. NM_016539.2NP_057623.2  NAD-dependent protein deacetylase sirtuin-6 isoform 1

    See proteins identical to NP_057623.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AF233396, AK074810, BC005026
    Consensus CDS
    CCDS12122.1
    UniProtKB/Swiss-Prot
    Q8N6T7
    Related
    ENSP00000337332, OTTHUMP00000267650, ENST00000337491, OTTHUMT00000457931
    Conserved Domains (1) summary
    cd01410
    Location:45257
    SIRT7; SIRT7: Eukaryotic and prokaryotic group (class4) which includes human sirtuin SIRT6, SIRT7, and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000019.10 

    Range
    4174109..4182599
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005259574.1XP_005259631.1  

    Conserved Domains (1) summary
    cl00195
    Location:45196
    SIR2; SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, ...
  2. XM_005259575.1XP_005259632.1  

    See proteins identical to XP_005259632.1

    UniProtKB/TrEMBL
    B4DDV3
    Conserved Domains (1) summary
    cl00195
    Location:1185
    SIR2; SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, ...
  3. XM_006722767.1XP_006722830.1  

    Conserved Domains (1) summary
    cl00195
    Location:42233
    SIR2; SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, ...
  4. XM_005259577.2XP_005259634.1  

    Conserved Domains (1) summary
    cl00195
    Location:45205
    SIR2; SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, ...

Alternate HuRef

Genomic

  1. AC_000151.1 

    Range
    3937486..3945942
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018930.2 

    Range
    4173652..4182142
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)