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FLT3 fms-related tyrosine kinase 3 [ Homo sapiens (human) ]

Gene ID: 2322, updated on 7-Jul-2014
Official Symbol
FLT3provided by HGNC
Official Full Name
fms-related tyrosine kinase 3provided by HGNC
Primary source
HGNC:3765
Locus tag
RP11-153M24.3
See related
Ensembl:ENSG00000122025; HPRD:00635; MIM:136351; Vega:OTTHUMG00000016646
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FLK2; STK1; CD135; FLK-2
Summary
This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. The receptor consists of an extracellular domain composed of five immunoglobulin-like domains, one transmembrane region, and a cytoplasmic kinase domain split into two parts by a kinase-insert domain. The receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia. [provided by RefSeq, Jul 2008]
See FLT3 in Epigenomics, MapViewer
Location:
13q12
Exon count :
24
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 13 NC_000013.11 (28003274..28100592, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (28577411..28682904, complement)

Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene caudal type homeobox 2 Neighboring gene ureidoimidazoline (2-oxo-4-hydroxy-4-carboxy-5-) decarboxylase Neighboring gene katanin p80 subunit B-like 1 pseudogene 1 Neighboring gene coiled-coil-helix-coiled-coil-helix domain containing 2 pseudogene 8 Neighboring gene PAN3 antisense RNA 1 Neighboring gene PAN3 poly(A) specific ribonuclease subunit

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
cytokine receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
phosphatidylinositol 3-kinase binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity TAS
Traceable Author Statement
more info
PubMed 
transmembrane receptor protein tyrosine kinase activity TAS
Traceable Author Statement
more info
PubMed 
vascular endothelial growth factor-activated receptor activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
B cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular response to cytokine stimulus ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular response to cytokine stimulus TAS
Traceable Author Statement
more info
PubMed 
common myeloid progenitor cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
cytokine-mediated signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
dendritic cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
hemopoiesis IDA
Inferred from Direct Assay
more info
PubMed 
leukocyte homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
 
lymphocyte proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
myeloid progenitor cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of B cell differentiation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cell proliferation IEA
Inferred from Electronic Annotation
more info
 
peptidyl-tyrosine phosphorylation TAS
Traceable Author Statement
more info
PubMed 
positive regulation of MAP kinase activity TAS
Traceable Author Statement
more info
PubMed 
positive regulation of MAPK cascade TAS
Traceable Author Statement
more info
PubMed 
positive regulation of cell proliferation TAS
Traceable Author Statement
more info
PubMed 
positive regulation of phosphatidylinositol 3-kinase activity TAS
Traceable Author Statement
more info
PubMed 
positive regulation of phosphatidylinositol 3-kinase signaling TAS
Traceable Author Statement
more info
PubMed 
positive regulation of tyrosine phosphorylation of STAT protein TAS
Traceable Author Statement
more info
PubMed 
pro-B cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
pro-T cell differentiation IEA
Inferred from Electronic Annotation
more info
 
protein autophosphorylation TAS
Traceable Author Statement
more info
PubMed 
regulation of apoptotic process TAS
Traceable Author Statement
more info
PubMed 
transmembrane receptor protein tyrosine kinase signaling pathway TAS
Traceable Author Statement
more info
PubMed 
vascular endothelial growth factor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cell surface IEA
Inferred from Electronic Annotation
more info
 
endoplasmic reticulum lumen IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
Preferred Names
receptor-type tyrosine-protein kinase FLT3
Names
receptor-type tyrosine-protein kinase FLT3
STK-1
CD135 antigen
FL cytokine receptor
fetal liver kinase 2
fms-like tyrosine kinase 3
stem cell tyrosine kinase 1
growth factor receptor tyrosine kinase type III
NP_004110.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_007066.1 

    Range
    4977..102295
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_457

mRNA and Protein(s)

  1. NM_004119.2NP_004110.2  receptor-type tyrosine-protein kinase FLT3

    See proteins identical to NP_004110.2

    Status: REVIEWED

    Source sequence(s)
    AL356915, AL591024, AW057705, BI461248, U02687, Z26652
    Consensus CDS
    CCDS31953.1
    UniProtKB/Swiss-Prot
    P36888
    Related
    ENSP00000241453, OTTHUMP00000018181, ENST00000241453, OTTHUMT00000044319
    Conserved Domains (3) summary
    pfam00047
    Location:265331
    Blast Score: 109
    ig; Immunoglobulin domain
    pfam07714
    Location:610943
    Blast Score: 995
    Pkinase_Tyr; Protein tyrosine kinase
    cl09925
    Location:572947
    Blast Score: 1487
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000013.11 

    Range
    28003274..28100592
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

  1. AC_000145.1 

    Range
    9398611..9496033
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018924.2 

    Range
    28546018..28643312
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

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