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    MSR1 macrophage scavenger receptor 1 [ Homo sapiens (human) ]

    Gene ID: 4481, updated on 17-Jul-2016
    Official Symbol
    MSR1provided by HGNC
    Official Full Name
    macrophage scavenger receptor 1provided by HGNC
    Primary source
    HGNC:HGNC:7376
    See related
    Ensembl:ENSG00000038945 HPRD:01092; MIM:153622; Vega:OTTHUMG00000094809
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SRA; SR-A; CD204; phSR1; phSR2; SCARA1
    Summary
    This gene encodes the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing of this gene. These receptors or isoforms are macrophage-specific trimeric integral membrane glycoproteins and have been implicated in many macrophage-associated physiological and pathological processes including atherosclerosis, Alzheimer's disease, and host defense. The isoforms type 1 and type 2 are functional receptors and are able to mediate the endocytosis of modified low density lipoproteins (LDLs). The isoform type 3 does not internalize modified LDL (acetyl-LDL) despite having the domain shown to mediate this function in the types 1 and 2 isoforms. It has an altered intracellular processing and is trapped within the endoplasmic reticulum, making it unable to perform endocytosis. The isoform type 3 can inhibit the function of isoforms type 1 and type 2 when co-expressed, indicating a dominant negative effect and suggesting a mechanism for regulation of scavenger receptor activity in macrophages. [provided by RefSeq, Jul 2008]
    Orthologs
    Location:
    8p22
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 8 NC_000008.11 (16107878..16192791, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (15965387..16050300, complement)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene protein phosphatase, Mg2+/Mn2+ dependent 1A pseudogene 1 Neighboring gene ribosomal protein L32 pseudogene 19 Neighboring gene chaperonin containing TCP1 subunit 3 pseudogene 1 Neighboring gene uncharacterized LOC101929028 Neighboring gene mitochondrial ribosomal protein L49 pseudogene 2

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    • AGE/RAGE pathway, organism-specific biosystem (from WikiPathways)
      AGE/RAGE pathway, organism-specific biosystemAdvanced glycation end products (AGEs) are heterogeneous group of non-enzymatic malliard reaction products of aldose sugar with proteins and lipids. Formation of AGEs is an indicator of one of the ma...
    • Binding and Uptake of Ligands by Scavenger Receptors, organism-specific biosystem (from REACTOME)
      Binding and Uptake of Ligands by Scavenger Receptors, organism-specific biosystemScavenger receptors bind free extracellular ligands as the initial step in clearance of the ligands from the body (reviewed in Ascenzi et al. 2005, Areschoug and Gordon 2009, Nielsen et al. 2010). So...
    • Phagosome, organism-specific biosystem (from KEGG)
      Phagosome, organism-specific biosystemPhagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is...
    • Phagosome, conserved biosystem (from KEGG)
      Phagosome, conserved biosystemPhagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is...
    • Scavenging by Class A Receptors, organism-specific biosystem (from REACTOME)
      Scavenging by Class A Receptors, organism-specific biosystemClass A scavenger receptors contain an intracellular domain, a transmembrane region, a coiled-coil domain, a collagenous domain, and the SR cysteine-rich domain (reviewed in Areschoug and Gordon 2009...
    • Vesicle-mediated transport, organism-specific biosystem (from REACTOME)
      Vesicle-mediated transport, organism-specific biosystemThe transit of proteins and other cargo through the cell requires a cellular transport process in which transported substances are moved in membrane-bounded vesicles. Transported substances are enclo...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    low-density lipoprotein particle binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    scavenger receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    cellular response to organic cyclic compound IEA
    Inferred from Electronic Annotation
    more info
     
    cholesterol transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    lipoprotein transport IEA
    Inferred from Electronic Annotation
    more info
     
    plasma lipoprotein particle clearance ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    positive regulation of cholesterol storage ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of macrophage derived foam cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    receptor-mediated endocytosis TAS
    Traceable Author Statement
    more info
     
    Component Evidence Code Pubs
    collagen trimer IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    endocytic vesicle membrane TAS
    Traceable Author Statement
    more info
     
    integral component of plasma membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    low-density lipoprotein particle IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane TAS
    Traceable Author Statement
    more info
     
    Preferred Names
    macrophage scavenger receptor types I and II
    Names
    macrophage acetylated LDL receptor I and II
    macrophage scavenger receptor type III
    scavenger receptor class A member 1
    scavenger receptor class A, member 1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_012102.1 RefSeqGene

      Range
      5001..89914
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_002445.3NP_002436.1  macrophage scavenger receptor types I and II isoform type 2

      See identical proteins and their annotated locations for NP_002436.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (SR-AII), also known as phSR2, uses two alternative exons and also lacks two downstream exons compared to variant SR-AI. These differences causes an alternate 3' end in the coding region, and has a distinct 3' UTR. It encodes isoform type 2 that is shorter and has a different C-terminus than isoform type 1.
      Source sequence(s)
      AC023396, D90188, DA995755
      Consensus CDS
      CCDS5997.1
      UniProtKB/Swiss-Prot
      P21757
      Related
      ENSP00000371428, OTTHUMP00000120050, ENST00000381998, OTTHUMT00000211635
      Conserved Domains (3) summary
      pfam01391
      Location:280334
      Collagen; Collagen triple helix repeat (20 copies)
      pfam03523
      Location:121169
      Macscav_rec; Macrophage scavenger receptor
      pfam05615
      Location:149249
      THOC7; Tho complex subunit 7
    2. NM_138715.2NP_619729.1  macrophage scavenger receptor types I and II isoform type 1

      See identical proteins and their annotated locations for NP_619729.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (SR-AI), also known as phSR1, encodes the longest isoform.
      Source sequence(s)
      AC023396, D90187, DA995755
      Consensus CDS
      CCDS5995.1
      UniProtKB/Swiss-Prot
      P21757
      Related
      ENSP00000262101, OTTHUMP00000120042, ENST00000262101, OTTHUMT00000211627
      Conserved Domains (4) summary
      pfam01391
      Location:280334
      Collagen; Collagen triple helix repeat (20 copies)
      smart00202
      Location:350450
      SR; Scavenger receptor Cys-rich
      pfam03523
      Location:121169
      Macscav_rec; Macrophage scavenger receptor
      pfam05615
      Location:149249
      THOC7; Tho complex subunit 7
    3. NM_138716.2NP_619730.1  macrophage scavenger receptor types I and II isoform type 3

      See identical proteins and their annotated locations for NP_619730.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (SR-AIII) lacks an exon in the coding region, but maintains the same reading frame, as compared to variant SR-AI. It encodes an isoform type 3 that lacks 63 internal amino acids compared to isoform type 1.
      Source sequence(s)
      AC023396, D90187, DA995755
      Consensus CDS
      CCDS5996.1
      UniProtKB/Swiss-Prot
      P21757
      Related
      ENSP00000262100, ENST00000350896
      Conserved Domains (4) summary
      pfam01391
      Location:280334
      Collagen; Collagen triple helix repeat (20 copies)
      pfam00530
      Location:331387
      SRCR; Scavenger receptor cysteine-rich domain
      pfam03523
      Location:121169
      Macscav_rec; Macrophage scavenger receptor
      pfam05615
      Location:149249
      THOC7; Tho complex subunit 7

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p7 Primary Assembly

      Range
      16107878..16192791 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.1

    Genomic

    1. NC_018919.2 Alternate CHM1_1.1

      Range
      16167312..16251899 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)