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PLK4 polo-like kinase 4 [ Homo sapiens (human) ]

Gene ID: 10733, updated on 7-Dec-2014
Official Symbol
PLK4provided by HGNC
Official Full Name
polo-like kinase 4provided by HGNC
Primary source
HGNC:HGNC:11397
See related
Ensembl:ENSG00000142731; HPRD:10387; MIM:605031; Vega:OTTHUMG00000133301
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SAK; STK18
Summary
This gene encodes a member of the polo family of serine/threonine protein kinases. The protein localizes to centrioles, complex microtubule-based structures found in centrosomes, and regulates centriole duplication during the cell cycle. Three alternatively spliced transcript variants that encode different protein isoforms have been found for this gene. [provided by RefSeq, Jun 2010]
See PLK4 in Epigenomics, MapViewer
Location:
4q28
Exon count:
17
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 4 NC_000004.12 (127880861..127899224)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (128802016..128820379)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 31 Neighboring gene heat shock 70kDa protein 4-like Neighboring gene ribosomal protein L21 pseudogene 53 Neighboring gene uncharacterized LOC101927163 Neighboring gene major facilitator superfamily domain containing 8 Neighboring gene chromosome 4 open reading frame 29

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
identical protein binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein serine/threonine kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
G2/M transition of mitotic cell cycle TAS
Traceable Author Statement
more info
 
centriole replication IMP
Inferred from Mutant Phenotype
more info
PubMed 
de novo centriole assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
mitotic cell cycle TAS
Traceable Author Statement
more info
 
positive regulation of centriole replication IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of centriole replication IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
trophoblast giant cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
centriole IDA
Inferred from Direct Assay
more info
PubMed 
centrosome IDA
Inferred from Direct Assay
more info
PubMed 
cleavage furrow IEA
Inferred from Electronic Annotation
more info
 
cytosol TAS
Traceable Author Statement
more info
 
deuterosome ISS
Inferred from Sequence or Structural Similarity
more info
 
nucleolus ISS
Inferred from Sequence or Structural Similarity
more info
 
Preferred Names
serine/threonine-protein kinase PLK4
Names
serine/threonine-protein kinase PLK4
PLK-4
Snk akin kinase
serine/threonine kinase 18
serine/threonine-protein kinase 18
serine/threonine protein kinase SAK
serine/threonine-protein kinase Sak
NP_001177728.1
NP_001177730.1
NP_055079.3

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001190799.1NP_001177728.1  serine/threonine-protein kinase PLK4 isoform 2

    See proteins identical to NP_001177728.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate 5' coding exon, compared to variant 1. The resulting protein (isoform 2) has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AI088969, AK303399, BU633758, DC402409
    Consensus CDS
    CCDS54803.1
    UniProtKB/Swiss-Prot
    O00444
    Related
    ENSP00000427554, OTTHUMP00000219884, ENST00000513090, OTTHUMT00000364136
    Conserved Domains (5) summary
    smart00220
    Location:12233
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd13114
    Location:555666
    POLO_box_Plk4_1; First (cryptic) polo-box domain (PBD) of polo-like kinase 4 (Plk4/Sak)
    cd13115
    Location:667775
    POLO_box_Plk4_2; Second (cryptic) polo-box domain (PBD) of polo-like kinase 4 (Plk4/Sak)
    cd13116
    Location:852931
    POLO_box_Plk4_3; C-terminal (third) polo-box domain (PBD) of polo-like kinase 4 (Plk4/Sak)
    cl09925
    Location:18233
    PKc_like; Protein Kinases, catalytic domain
  2. NM_001190801.1NP_001177730.1  serine/threonine-protein kinase PLK4 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) contains a different first exon, which results in the use of a in-frame downstream start codon, compared to variant 1. The resulting protein (isoform 3) is shorter when it is compared to isoform 1.
    Source sequence(s)
    AI088969, AK302858, BC036023, BU633758
    Consensus CDS
    CCDS54804.1
    UniProtKB/Swiss-Prot
    O00444
    Related
    ENSP00000423582, OTTHUMP00000219883, ENST00000514379, OTTHUMT00000364135
    Conserved Domains (5) summary
    cd05123
    Location:1224
    STKc_AGC; Catalytic domain of AGC family Protein Serine/Threonine Kinases
    smart00220
    Location:1224
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd13114
    Location:546657
    POLO_box_Plk4_1; First (cryptic) polo-box domain (PBD) of polo-like kinase 4 (Plk4/Sak)
    cd13115
    Location:658766
    POLO_box_Plk4_2; Second (cryptic) polo-box domain (PBD) of polo-like kinase 4 (Plk4/Sak)
    cd13116
    Location:843922
    POLO_box_Plk4_3; C-terminal (third) polo-box domain (PBD) of polo-like kinase 4 (Plk4/Sak)
  3. NM_014264.4NP_055079.3  serine/threonine-protein kinase PLK4 isoform 1

    See proteins identical to NP_055079.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and it encodes the longest protein (isoform 1).
    Source sequence(s)
    AI088969, BC036023, BU633758, DC402409
    Consensus CDS
    CCDS3735.1
    UniProtKB/Swiss-Prot
    O00444
    Related
    ENSP00000270861, OTTHUMP00000164423, ENST00000270861, OTTHUMT00000257095
    Conserved Domains (5) summary
    cd05123
    Location:18265
    STKc_AGC; Catalytic domain of AGC family Protein Serine/Threonine Kinases
    smart00220
    Location:12265
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd13114
    Location:587698
    POLO_box_Plk4_1; First (cryptic) polo-box domain (PBD) of polo-like kinase 4 (Plk4/Sak)
    cd13115
    Location:699807
    POLO_box_Plk4_2; Second (cryptic) polo-box domain (PBD) of polo-like kinase 4 (Plk4/Sak)
    cd13116
    Location:884963
    POLO_box_Plk4_3; C-terminal (third) polo-box domain (PBD) of polo-like kinase 4 (Plk4/Sak)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000004.12 

    Range
    127880861..127899224
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006714071.1XP_006714134.1  

    Conserved Domains (5) summary
    cd05123
    Location:1218
    STKc_AGC; Catalytic domain of AGC family Protein Serine/Threonine Kinases
    smart00220
    Location:5218
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd13114
    Location:540651
    POLO_box_Plk4_1; First (cryptic) polo-box domain (PBD) of polo-like kinase 4 (Plk4/Sak)
    cd13115
    Location:652760
    POLO_box_Plk4_2; Second (cryptic) polo-box domain (PBD) of polo-like kinase 4 (Plk4/Sak)
    cd13116
    Location:837916
    POLO_box_Plk4_3; C-terminal (third) polo-box domain (PBD) of polo-like kinase 4 (Plk4/Sak)
  2. XM_005262701.1XP_005262758.1  

    Related
    ENSP00000423412, OTTHUMP00000219886, ENST00000507249, OTTHUMT00000364138
    Conserved Domains (5) summary
    cd05123
    Location:18265
    STKc_AGC; Catalytic domain of AGC family Protein Serine/Threonine Kinases
    smart00220
    Location:12265
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd13114
    Location:553664
    POLO_box_Plk4_1; First (cryptic) polo-box domain (PBD) of polo-like kinase 4 (Plk4/Sak)
    cd13115
    Location:665773
    POLO_box_Plk4_2; Second (cryptic) polo-box domain (PBD) of polo-like kinase 4 (Plk4/Sak)
    cd13116
    Location:850929
    POLO_box_Plk4_3; C-terminal (third) polo-box domain (PBD) of polo-like kinase 4 (Plk4/Sak)

Alternate CHM1_1.1

Genomic

  1. NC_018915.2 

    Range
    128778476..128796837
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

  1. AC_000136.1 

    Range
    124529792..124548157
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)