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WDR61 WD repeat domain 61 [ Homo sapiens (human) ]

Gene ID: 80349, updated on 27-Feb-2015
Official Symbol
WDR61provided by HGNC
Official Full Name
WD repeat domain 61provided by HGNC
Primary source
HGNC:HGNC:30300
See related
Ensembl:ENSG00000140395; HPRD:15236; MIM:609540; Vega:OTTHUMG00000143735
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SKI8; REC14
Summary
WDR61 is a subunit of the human PAF and SKI complexes, which function in transcriptional regulation and are involved in events downstream of RNA synthesis, such as RNA surveillance (Zhu et al., 2005 [PubMed 16024656]).[supplied by OMIM, Mar 2008]
Orthologs
See WDR61 in MapViewer
Location:
15q25.1
Exon count:
11
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 15 NC_000015.10 (78283233..78299598, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (78575575..78591977, complement)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene acyl-CoA synthetase bubblegum family member 1 Neighboring gene DnaJ (Hsp40) homolog, subfamily A, member 4 Neighboring gene cellular retinoic acid binding protein 1 Neighboring gene RWD domain containing 1 pseudogene 1

Protein interactions

Protein Gene Interaction Pubs
integrase gag-pol HIV-1 IN is identified to have a physical interaction with WD repeat domain 61 (WDR61) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

  • RNA degradation, organism-specific biosystem (from KEGG)
    RNA degradation, organism-specific biosystemThe correct processing, quality control and turnover of cellular RNA molecules are critical to many aspects in the expression of genetic information. In eukaryotes, two major pathways of mRNA decay e...
  • RNA degradation, conserved biosystem (from KEGG)
    RNA degradation, conserved biosystemThe correct processing, quality control and turnover of cellular RNA molecules are critical to many aspects in the expression of genetic information. In eukaryotes, two major pathways of mRNA decay e...
  • Ski complex, organism-specific biosystem (from KEGG)
    Ski complex, organism-specific biosystemStructural complex; Genetic information processing; RNA processing
  • Ski complex, conserved biosystem (from KEGG)
    Ski complex, conserved biosystemStructural complex; Genetic information processing; RNA processing
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
Cdc73/Paf1 complex IDA
Inferred from Direct Assay
more info
PubMed 
Ski complex IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
transcriptionally active chromatin IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
WD repeat-containing protein 61
Names
WD repeat-containing protein 61
SKI8 homolog
meiotic recombination REC14 protein homolog
recombination protein REC14

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001303247.1NP_001290176.1  WD repeat-containing protein 61 isoform a

    See proteins identical to NP_001290176.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Variants 1 and 2 both encode isoform a.
    Source sequence(s)
    AK024754, BI916225, DB451240
    UniProtKB/Swiss-Prot
    Q9GZS3
    Conserved Domains (2) summary
    COG2319
    Location:13304
    COG2319; FOG: WD40 repeat [General function prediction only]
    cd00200
    Location:13302
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  2. NM_001303248.1NP_001290177.1  WD repeat-containing protein 61 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and lacks an alternate in-frame pair of exons in the middle of the transcript compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
    Source sequence(s)
    AK024754, BI916225, BU528743
    UniProtKB/TrEMBL
    H0YL19
    UniProtKB/Swiss-Prot
    Q9GZS3
    Conserved Domains (2) summary
    COG2319
    Location:15211
    COG2319; FOG: WD40 repeat [General function prediction only]
    cd00200
    Location:17209
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  3. NM_025234.2NP_079510.1  WD repeat-containing protein 61 isoform a

    See proteins identical to NP_079510.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same isoform (a).
    Source sequence(s)
    AK024754, BI916225
    Consensus CDS
    CCDS10300.1
    UniProtKB/Swiss-Prot
    Q9GZS3
    Related
    ENSP00000267973, OTTHUMP00000184910, ENST00000267973, OTTHUMT00000289803
    Conserved Domains (2) summary
    COG2319
    Location:13304
    COG2319; FOG: WD40 repeat [General function prediction only]
    cd00200
    Location:13302
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38 Primary Assembly

    Range
    78283233..78299598
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005254698.1XP_005254755.1  

    Related
    ENSP00000453902, OTTHUMP00000248762, ENST00000560569, OTTHUMT00000419243
    Conserved Domains (2) summary
    COG2319
    Location:13304
    COG2319; FOG: WD40 repeat [General function prediction only]
    cd00200
    Location:13302
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

Alternate CHM1_1.1

Genomic

  1. NC_018926.2 Alternate CHM1_1.1

    Range
    78693544..78709912
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

  1. AC_000147.1 Alternate HuRef

    Range
    55333673..55350040
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)