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ARID2 AT rich interactive domain 2 (ARID, RFX-like) [ Homo sapiens (human) ]

Gene ID: 196528, updated on 24-Jan-2015
Official Symbol
ARID2provided by HGNC
Official Full Name
AT rich interactive domain 2 (ARID, RFX-like)provided by HGNC
Primary source
HGNC:HGNC:18037
See related
Ensembl:ENSG00000189079; HPRD:16505; MIM:609539; Vega:OTTHUMG00000150487
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
p200; BAF200
Summary
ARID2 is a subunit of the PBAF chromatin-remodeling complex (see BAF180; MIM 606083), which facilitates ligand-dependent transcriptional activation by nuclear receptors (Yan et al., 2005 [PubMed 15985610]).[supplied by OMIM, Mar 2008]
Orthologs
See ARID2 in MapViewer
Location:
12q12
Exon count:
22
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 12 NC_000012.12 (45729691..45908037)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (46123494..46301820)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene mesoderm development candidate 2 pseudogene Neighboring gene long intergenic non-protein coding RNA 938 Neighboring gene lysine-rich nucleolar protein 1 pseudogene 2 Neighboring gene SR-related CTD-associated factor 11 Neighboring gene ribosomal protein L13a pseudogene 21

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Hippocampal atrophy as a quantitative trait in a genome-wide association study identifying novel susceptibility genes for Alzheimer's disease.
NHGRI GWA Catalog

Protein interactions

Protein Gene Interaction Pubs
Tat tat A PBAF-specific component BAF200 is required for HIV-1 Tat-mediated activation of HIV LTR PubMed
tat Acetylated HIV-1 Tat binds efficiently to BRG1 and BAF200 (component of PBAF complex) and weakly to BAF250 (component of BAF complex) PubMed

Go to the HIV-1, Human Interaction Database

  • Chromatin modifying enzymes, organism-specific biosystem (from REACTOME)
    Chromatin modifying enzymes, organism-specific biosystemEukaryotic DNA is associated with histone proteins and organized into a complex nucleoprotein structure called chromatin. This structure decreases the accessibility of DNA but also helps to protect i...
  • Chromatin organization, organism-specific biosystem (from REACTOME)
    Chromatin organization, organism-specific biosystemChromatin organization refers to the composition and conformation of complexes between DNA, protein and RNA. It is determined by processes that result in the specification, formation or maintenance o...
  • RMTs methylate histone arginines, organism-specific biosystem (from REACTOME)
    RMTs methylate histone arginines, organism-specific biosystemArginine methylation is a common post-translational modification; around 2% of arginine residues are methylated in rat liver nuclei (Boffa et al. 1977). Arginine can be methylated in 3 different ways...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ30619, KIAA1557, DKFZp686G052, DKFZp779P0222

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
chromatin modification IEA
Inferred from Electronic Annotation
more info
 
nucleosome disassembly IDA
Inferred from Direct Assay
more info
PubMed 
regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
nucleoplasm IDA
Inferred from Direct Assay
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
 
Preferred Names
AT-rich interactive domain-containing protein 2
Names
AT-rich interactive domain-containing protein 2
zipzap
zipzap/p200
BRG1-associated factor 200
ARID domain-containing protein 2
zinc finger protein with activation potential

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_152641.2NP_689854.2  AT-rich interactive domain-containing protein 2

    See proteins identical to NP_689854.2

    Status: VALIDATED

    Source sequence(s)
    AB046777, AL832200, AY727870, BX649133, CN419675
    Consensus CDS
    CCDS31783.1
    UniProtKB/Swiss-Prot
    Q68CP9
    Related
    ENSP00000335044, OTTHUMP00000197509, ENST00000334344, OTTHUMT00000318380
    Conserved Domains (3) summary
    smart01014
    Location:14101
    ARID; ARID/BRIGHT DNA binding domain
    pfam02257
    Location:522603
    RFX_DNA_binding; RFX DNA-binding domain
    pfam09606
    Location:7931235
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000012.12 

    Range
    45729691..45908037
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006719272.1XP_006719335.1  

    See proteins identical to XP_006719335.1

    Conserved Domains (3) summary
    smart01014
    Location:14101
    ARID; ARID/BRIGHT DNA binding domain
    pfam02257
    Location:522603
    RFX_DNA_binding; RFX DNA-binding domain
    pfam09606
    Location:7931235
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
  2. XM_006719273.1XP_006719336.1  

    Conserved Domains (3) summary
    smart01014
    Location:14101
    ARID; ARID/BRIGHT DNA binding domain
    pfam02257
    Location:466547
    RFX_DNA_binding; RFX DNA-binding domain
    pfam09606
    Location:7371179
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

Alternate CHM1_1.1

Genomic

  1. NC_018923.2 

    Range
    46088579..46266707
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

  1. AC_000144.1 

    Range
    43152842..43332608
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)