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    FZR1 fizzy/cell division cycle 20 related 1 [ Homo sapiens (human) ]

    Gene ID: 51343, updated on 8-Aug-2016
    Official Symbol
    FZR1provided by HGNC
    Official Full Name
    fizzy/cell division cycle 20 related 1provided by HGNC
    Primary source
    HGNC:HGNC:24824
    See related
    Ensembl:ENSG00000105325 HPRD:04687; MIM:603619; Vega:OTTHUMG00000180747
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FZR; CDH1; FZR2; HCDH; HCDH1; CDC20C
    Orthologs
    Location:
    19p13.3
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 19 NC_000019.10 (3506115..3536757)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (3506261..3536755)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105372246 Neighboring gene uncharacterized LOC105372245 Neighboring gene deoxyhypusine hydroxylase/monooxygenase Neighboring gene chromosome 19 open reading frame 71 Neighboring gene major facilitator superfamily domain containing 12 Neighboring gene high mobility group 20B

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Homology

    Clone Names

    • KIAA1242

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    anaphase-promoting complex binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    ubiquitin-protein transferase activator activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    DNA repair IEA
    Inferred from Electronic Annotation
    more info
     
    G2 DNA damage checkpoint IDA
    Inferred from Direct Assay
    more info
    PubMed 
    anaphase-promoting complex-dependent catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    anaphase-promoting complex-dependent catabolic process TAS
    Traceable Author Statement
    more info
     
    cell division IEA
    Inferred from Electronic Annotation
    more info
     
    lens fiber cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    mitotic nuclear division IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of cell aging IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle TAS
    Traceable Author Statement
    more info
     
    positive regulation of cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of protein catabolic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of ubiquitin protein ligase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition TAS
    Traceable Author Statement
    more info
     
    protein K11-linked ubiquitination TAS
    Traceable Author Statement
    more info
    PubMed 
    protein ubiquitination involved in ubiquitin-dependent protein catabolic process TAS
    Traceable Author Statement
    more info
     
    regulation of meiotic nuclear division IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle TAS
    Traceable Author Statement
    more info
     
    Component Evidence Code Pubs
    colocalizes_with anaphase-promoting complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol TAS
    Traceable Author Statement
    more info
     
    nuclear membrane IDA
    Inferred from Direct Assay
    more info
     
    nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    nucleoplasm TAS
    Traceable Author Statement
    more info
     
    Preferred Names
    fizzy-related protein homolog
    Names
    CDC20 homolog 1
    CDC20-like 1b
    CDC20-like protein 1
    cdh1/Hct1 homolog

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001136197.1NP_001129669.1  fizzy-related protein homolog isoform 3

      See identical proteins and their annotated locations for NP_001129669.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) skips multiple exons in the central coding region and lacks a short in-frame segment in the 3' coding region compared to variant 1. The encoded protein (isoform 3) lacks a WD40 repeat and has a shorter C-terminus compared to isoform 1. This isoform is also known as isoform beta.
      Source sequence(s)
      AB033068, AF083810, AF433157, BC013413
      Consensus CDS
      CCDS45917.1
      UniProtKB/Swiss-Prot
      Q9UM11
      Related
      ENSP00000321800, OTTHUMP00000265234, ENST00000313639, OTTHUMT00000452938
      Conserved Domains (3) summary
      COG2319
      Location:127401
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:127382
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:143180
      7WD40; WD40 repeat [structural motif]
    2. NM_001136198.1NP_001129670.1  fizzy-related protein homolog isoform 1

      See identical proteins and their annotated locations for NP_001129670.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform.
      Source sequence(s)
      AB013462, AB033068, AF083810, BC013413
      Consensus CDS
      CCDS45916.1
      UniProtKB/Swiss-Prot
      Q9UM11
      Related
      ENSP00000378529, OTTHUMP00000265183, ENST00000395095, OTTHUMT00000452869
      Conserved Domains (2) summary
      COG2319
      Location:189478
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:193471
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    3. NM_016263.3NP_057347.2  fizzy-related protein homolog isoform 2

      See identical proteins and their annotated locations for NP_057347.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks a short in-frame segment in the 3' coding region compared to variant 1. The encoded protein (isoform 2) has a shorter C-terminus compared to isoform 1. This isoform is also known as isoform alpha.
      Source sequence(s)
      AF083810, BC013413, BC111760, DB462260
      Consensus CDS
      CCDS12109.1
      UniProtKB/Swiss-Prot
      Q9UM11
      Related
      ENSP00000410369, OTTHUMP00000265182, ENST00000441788, OTTHUMT00000452868
      Conserved Domains (3) summary
      COG2319
      Location:189490
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:193471
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:232269
      7WD40; WD40 repeat [structural motif]

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p7 Primary Assembly

      Range
      3506115..3536757
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005259573.4XP_005259630.1  

      See identical proteins and their annotated locations for XP_005259630.1

      UniProtKB/Swiss-Prot
      Q9UM11
      Conserved Domains (2) summary
      COG2319
      Location:189478
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:193471
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    2. XM_017026863.1XP_016882352.1  

    RNA

    1. XR_001753699.1 RNA Sequence

    Alternate CHM1_1.1

    Genomic

    1. NC_018930.2 Alternate CHM1_1.1

      Range
      3505941..3536425
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)