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    MINA MYC induced nuclear antigen [ Homo sapiens (human) ]

    Gene ID: 84864, updated on 26-Jun-2015
    Official Symbol
    MINAprovided by HGNC
    Official Full Name
    MYC induced nuclear antigenprovided by HGNC
    Primary source
    HGNC:HGNC:19441
    See related
    Ensembl:ENSG00000170854; HPRD:17575; MIM:612049; Vega:OTTHUMG00000160107
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ROX; MDIG; NO52; MINA53
    Summary
    MINA is a c-Myc (MYC; MIM 190080) target gene that may play a role in cell proliferation or regulation of cell growth. (Tsuneoka et al., 2002 [PubMed 12091391]; Zhang et al., 2005 [PubMed 15897898]).[supplied by OMIM, May 2008]
    Orthologs
    See MINA in Epigenomics, MapViewer
    Location:
    3q11.2
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    107 current GRCh38.p2 (GCF_000001405.28) 3 NC_000003.12 (97941817..97972451, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (97660661..97691295, complement)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene ADP-ribosylation factor-like 6 Neighboring gene uncharacterized LOC101929298 Neighboring gene uncharacterized LOC105373994 Neighboring gene beta-gamma crystallin domain containing 3 Neighboring gene gamma-aminobutyric acid (GABA) A receptor, rho 3 (gene/pseudogene) Neighboring gene olfactory receptor, family 5, subfamily BM, member 1 pseudogene

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Clone Names

    • FLJ14393, DKFZp762O1912

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    RNA polymerase II transcription factor binding transcription repressor activity IEA
    Inferred from Electronic Annotation
    more info
     
    dioxygenase activity IEA
    Inferred from Electronic Annotation
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    negative regulation of transcription from RNA polymerase II promoter IEA
    Inferred from Electronic Annotation
    more info
     
    oxidation-reduction process IEA
    Inferred from Electronic Annotation
    more info
     
    ribosome biogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
     
    cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    nucleolus IDA
    Inferred from Direct Assay
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
     
    transcription factor complex IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    bifunctional lysine-specific demethylase and histidyl-hydroxylase MINA
    Names
    bifunctional lysine-specific demethylase and histidyl-hydroxylase MINA
    60S ribosomal protein L27a histidine hydroxylase
    MINA
    histone lysine demethylase MINA
    mineral dust induced gene protein
    mineral dust-induced gene protein
    myc-induced nuclear antigen, 53 kDa
    nucleolar protein 52
    ribosomal oxygenase MINA

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001042533.2NP_001035998.1  bifunctional lysine-specific demethylase and histidyl-hydroxylase MINA isoform a

      See identical proteins and their annotated locations for NP_001035998.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (A). Variants 1 and 2 encode the same protein (isoform A).
      Source sequence(s)
      AC110491, AL550737, AY302110, DA310030
      Consensus CDS
      CCDS43114.1
      UniProtKB/Swiss-Prot
      Q8IUF8
      Related
      ENSP00000328251, OTTHUMP00000217525, ENST00000333396, OTTHUMT00000359244
      Conserved Domains (1) summary
      pfam08007
      Location:52364
      Cupin_4; Cupin superfamily protein
    2. NM_001261829.1NP_001248758.1  bifunctional lysine-specific demethylase and histidyl-hydroxylase MINA isoform b

      See identical proteins and their annotated locations for NP_001248758.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) uses alternate splice sites in the 5' UTR and 3' coding region, compared to variant 1, and encodes a shorter protein (isoform B), compared to isoform A. Variants 3 and 4 encode the same protein (isoform B).
      Source sequence(s)
      AC026100, AC110491, AK027299, DA310030
      Consensus CDS
      CCDS2929.1
      UniProtKB/Swiss-Prot
      Q8IUF8
      Conserved Domains (1) summary
      pfam08007
      Location:52363
      Cupin_4; Cupin superfamily protein
    3. NM_032778.5NP_116167.3  bifunctional lysine-specific demethylase and histidyl-hydroxylase MINA isoform b

      See identical proteins and their annotated locations for NP_116167.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate splice site in the 3' coding region, compared to variant 1, and encodes a shorter protein (isoform B), compared to isoform A. Variants 3 and 4 encode the same protein (isoform B).
      Source sequence(s)
      AB083190, AC026100, AC110491, AL550737, DA310030
      Consensus CDS
      CCDS2929.1
      UniProtKB/Swiss-Prot
      Q8IUF8
      Conserved Domains (1) summary
      pfam08007
      Location:52363
      Cupin_4; Cupin superfamily protein
    4. NM_153182.3NP_694822.2  bifunctional lysine-specific demethylase and histidyl-hydroxylase MINA isoform a

      See identical proteins and their annotated locations for NP_694822.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the 5' UTR, compared to variant 1, and encodes isoform A. Variants 1 and 2 encode the same protein (isoform A).
      Source sequence(s)
      AC110491, DA310030, DQ453796
      Consensus CDS
      CCDS43114.1
      UniProtKB/Swiss-Prot
      Q8IUF8
      Conserved Domains (1) summary
      pfam08007
      Location:52364
      Cupin_4; Cupin superfamily protein

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p2 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p2 Primary Assembly

      Range
      97941817..97972451
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011513244.1XP_011511546.1  

      Conserved Domains (1) summary
      cl22893
      Location:7133
      JmjC; JmjC domain, hydroxylase
    2. XM_005247838.3XP_005247895.1  

      See identical proteins and their annotated locations for XP_005247895.1

      UniProtKB/Swiss-Prot
      Q8IUF8
      Related
      ENSP00000377748, OTTHUMP00000217524, ENST00000394198, OTTHUMT00000359243
      Conserved Domains (1) summary
      pfam08007
      Location:52364
      Cupin_4; Cupin superfamily protein

    RNA

    1. XR_241516.3 RNA Sequence

    Alternate CHM1_1.1

    Genomic

    1. NC_018914.2 Alternate CHM1_1.1

      Range
      97623694..97654332
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)