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    MCM10 minichromosome maintenance 10 replication initiation factor [ Homo sapiens (human) ]

    Gene ID: 55388, updated on 25-Jul-2016
    Official Symbol
    MCM10provided by HGNC
    Official Full Name
    minichromosome maintenance 10 replication initiation factorprovided by HGNC
    Primary source
    HGNC:HGNC:18043
    See related
    Ensembl:ENSG00000065328 HPRD:11297; MIM:609357; Vega:OTTHUMG00000017694
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CNA43; DNA43; PRO2249
    Summary
    The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre-RC) and it may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein can interact with MCM2 and MCM6, as well as with the origin recognition protein ORC2. It is regulated by proteolysis and phosphorylation in a cell cycle-dependent manner. Studies of a similar protein in Xenopus suggest that the chromatin binding of this protein at the onset of DNA replication is after pre-RC assembly and before origin unwinding. Alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Jul 2008]
    Orthologs
    Location:
    10p13
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 10 NC_000010.11 (13161554..13211110)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (13203554..13253104)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene BTB domain containing 7 pseudogene 1 Neighboring gene ribosomal protein L36a pseudogene 36 Neighboring gene RNA, U6 small nuclear 6, pseudogene Neighboring gene upper zone of growth plate and cartilage matrix associated

    Related articles in PubMed

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Protein interactions

    Protein Gene Interaction Pubs
    Vpr vpr HIV-1 depletes MCM10 in a Vpr-dependent manner PubMed
    vpr HIV-1 Vpr enhances the proteasomal degradation of MCM10, (a natural substrate for the Cul4-DDB1[VprBP] E3 ubiquitin ligase whose degradation is regulated by VprBP), by interacting with VprBP PubMed
    vpr HIV-1 Vpr degrades MCM10 via Cul4-DDB1 E3 ubiquitin ligase proteasomal degradation pathway PubMed

    Go to the HIV-1, Human Interaction Database

    • Activation of ATR in response to replication stress, organism-specific biosystem (from REACTOME)
      Activation of ATR in response to replication stress, organism-specific biosystemGenotoxic stress caused by DNA damage or stalled replication forks can lead to genomic instability. To guard against such instability, genotoxically-stressed cells activate checkpoint factors that ha...
    • Activation of the pre-replicative complex, organism-specific biosystem (from REACTOME)
      Activation of the pre-replicative complex, organism-specific biosystemIn S. cerevisiae, two ORC subunits, Orc1 and Orc5, both bind ATP, and Orc1 in addition has ATPase activity. Both ATP binding and ATP hydrolysis appear to be essential functions in vivo. ATP binding b...
    • Cell Cycle, organism-specific biosystem (from REACTOME)
      Cell Cycle, organism-specific biosystem
      Cell Cycle
    • Cell Cycle Checkpoints, organism-specific biosystem (from REACTOME)
      Cell Cycle Checkpoints, organism-specific biosystemA hallmark of the human cell cycle in normal somatic cells is its precision. This remarkable fidelity is achieved by a number of signal transduction pathways, known as checkpoints, which monitor cell...
    • Cell Cycle, Mitotic, organism-specific biosystem (from REACTOME)
      Cell Cycle, Mitotic, organism-specific biosystemThe replication of the genome and the subsequent segregation of chromosomes into daughter cells are controlled by a series of events collectively known as the cell cycle. DNA replication is carried o...
    • Cell cycle, organism-specific biosystem (from WikiPathways)
      Cell cycle, organism-specific biosystemThe cell cycle is the series of events that takes place in a cell leading to its division and duplication (replication). Regulation of the cell cycle involves processes crucial to the survival of a c...
    • DNA Replication, organism-specific biosystem (from WikiPathways)
      DNA Replication, organism-specific biosystemStudies in the past decade have suggested that the basic mechanism of DNA replication initiation is conserved in all kingdoms of life. Initiation in unicellular eukaryotes, in particular Saccharomyce...
    • DNA Replication, organism-specific biosystem (from REACTOME)
      DNA Replication, organism-specific biosystemStudies in the past decade have suggested that the basic mechanism of DNA replication initiation is conserved in all kingdoms of life. Initiation in unicellular eukaryotes, in particular Saccharomyce...
    • DNA Replication Pre-Initiation, organism-specific biosystem (from REACTOME)
      DNA Replication Pre-Initiation, organism-specific biosystemAlthough, DNA replication occurs in the S phase of the cell cycle, the formation of the DNA replication pre-initiation complex begins during G1 phase.
    • G1/S Transition, organism-specific biosystem (from REACTOME)
      G1/S Transition, organism-specific biosystemCyclin E - Cdk2 complexes control the transition from G1 into S-phase. In this case, the binding of p21Cip1/Waf1 or p27kip1 is inhibitory. Important substrates for Cyclin E - Cdk2 complexes include p...
    • G2/M Checkpoints, organism-specific biosystem (from REACTOME)
      G2/M Checkpoints, organism-specific biosystemG2/M checkpoints include the checks for damaged DNA, unreplicated DNA, and checks that ensure that the genome is replicated once and only once per cell cycle. If cells pass these checkpoints, they f...
    • M/G1 Transition, organism-specific biosystem (from REACTOME)
      M/G1 Transition, organism-specific biosystemFinally, progression out of mitosis and division of the cell into two daughters (cytokinesis) requires the inactivation of Cyclin B - Cdc2 by ubiquitin-dependent proteolysis of Cyclin A and B, which ...
    • Mitotic G1-G1/S phases, organism-specific biosystem (from REACTOME)
      Mitotic G1-G1/S phases, organism-specific biosystem
      Mitotic G1-G1/S phases
    • Regulation of DNA replication, organism-specific biosystem (from REACTOME)
      Regulation of DNA replication, organism-specific biosystemDNA replication is regulated at various levels via ORC proteins. This pathway includes annotation of individual events that lead to the regulation of replication.
    • Removal of licensing factors from origins, organism-specific biosystem (from REACTOME)
      Removal of licensing factors from origins, organism-specific biosystemLicensing factors are removed from the origin by various means like biochemical modification (phosphorylation) or by physical association with other proteins. This pathway includes the annotations of...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • MGC126776

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    DNA replication origin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enzyme binding IEA
    Inferred from Electronic Annotation
    more info
     
    identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    single-stranded DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    DNA replication TAS
    Traceable Author Statement
    more info
     
    DNA replication initiation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    G1/S transition of mitotic cell cycle TAS
    Traceable Author Statement
    more info
     
    cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to DNA damage stimulus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
     
    nucleolus IDA
    Inferred from Direct Assay
    more info
     
    nucleoplasm TAS
    Traceable Author Statement
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    replication fork protection complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Preferred Names
    protein MCM10 homolog
    Names
    MCM10 minichromosome maintenance deficient 10
    homolog of yeast MCM10
    hsMCM10
    minichromosome maintenance complex component 10

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_018518.4NP_060988.3  protein MCM10 homolog isoform 2

      See identical proteins and their annotated locations for NP_060988.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) encodes the predominant isoform (2).
      Source sequence(s)
      AB042719, AL136840, DA024424
      Consensus CDS
      CCDS7095.1
      UniProtKB/Swiss-Prot
      Q7L590
      Related
      ENSP00000367986, OTTHUMP00000019133, ENST00000378714, OTTHUMT00000046849
      Conserved Domains (2) summary
      pfam09329
      Location:381426
      zf-primase; Primase zinc finger
      pfam09332
      Location:525872
      Mcm10; Mcm10 replication factor
    2. NM_182751.2NP_877428.1  protein MCM10 homolog isoform 1

      See identical proteins and their annotated locations for NP_877428.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) uses a different splice site, compared to variant 2, that results in a longer isoform (1). Though this variant is supported by EST data, the existence of its encoded isoform has not been experimentally verified.
      Source sequence(s)
      AB042719, AK055695, AL136840, DA024424
      Consensus CDS
      CCDS7096.1
      UniProtKB/Swiss-Prot
      Q7L590
      Related
      ENSP00000418268, OTTHUMP00000216196, ENST00000484800, OTTHUMT00000356853
      Conserved Domains (2) summary
      pfam09329
      Location:382427
      zf-primase; Primase zinc finger
      pfam09332
      Location:523873
      Mcm10; Mcm10 replication factor

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p7 Primary Assembly

      Range
      13161554..13211110
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011519538.2XP_011517840.1  

      See identical proteins and their annotated locations for XP_011517840.1

      UniProtKB/Swiss-Prot
      Q7L590
      Conserved Domains (2) summary
      pfam09329
      Location:382427
      zf-primase; Primase zinc finger
      pfam09332
      Location:523873
      Mcm10; Mcm10 replication factor

    Alternate CHM1_1.1

    Genomic

    1. NC_018921.2 Alternate CHM1_1.1

      Range
      13203749..13253219
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)