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    PIAS1 protein inhibitor of activated STAT 1 [ Homo sapiens (human) ]

    Gene ID: 8554, updated on 7-Feb-2016
    Official Symbol
    PIAS1provided by HGNC
    Official Full Name
    protein inhibitor of activated STAT 1provided by HGNC
    Primary source
    HGNC:HGNC:2752
    See related
    HPRD:16029; MIM:603566
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GBP; ZMIZ3; DDXBP1; GU/RH-II
    Summary
    This gene encodes a member of the mammalian PIAS [protein inhibitor of activated STAT-1 (signal transducer and activator of transcription-1)] family. This member contains a putative zinc-binding motif and a highly acidic region. It inhibits STAT1-mediated gene activation and the DNA binding activity, binds to Gu protein/RNA helicase II/DEAD box polypeptide 21, and interacts with androgen receptor (AR). It functions in testis as a nuclear receptor transcriptional coregulator and may have a role in AR initiation and maintenance of spermatogenesis. [provided by RefSeq, Jul 2008]
    Orthologs
    See PIAS1 in Epigenomics, MapViewer
    Location:
    15q
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    107 current GRCh38.p2 (GCF_000001405.28) 15 NC_000015.10 (68054234..68191459)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (68346572..68483797)

    Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene RNA, U6 small nuclear 1 Neighboring gene ribosomal protein S15a pseudogene Neighboring gene uncharacterized LOC105370871 Neighboring gene calmodulin like 4 Neighboring gene ceroid-lipofuscinosis, neuronal 6, late infantile, variant Neighboring gene high mobility group nucleosomal binding domain 2 pseudogene 40

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    NHGRI GWAS Catalog

    Description
    Common genetic variation and antidepressant efficacy in major depressive disorder: a meta-analysis of three genome-wide pharmacogenetic studies.
    NHGRI GWA Catalog
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    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • MGC141878, MGC141879

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    SUMO ligase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    androgen receptor binding NAS
    Non-traceable Author Statement
    more info
    PubMed 
    enzyme binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    ligase activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    transcription coactivator activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    transcription corepressor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    transcription factor binding IEA
    Inferred from Electronic Annotation
    more info
     
    ubiquitin protein ligase binding IEA
    Inferred from Electronic Annotation
    more info
     
    zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    JAK-STAT cascade TAS
    Traceable Author Statement
    more info
    PubMed 
    androgen receptor signaling pathway NAS
    Non-traceable Author Statement
    more info
    PubMed 
    cellular protein metabolic process TAS
    Traceable Author Statement
    more info
     
    cytokine-mediated signaling pathway TAS
    Traceable Author Statement
    more info
     
    fat cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    interferon-gamma-mediated signaling pathway TAS
    Traceable Author Statement
    more info
     
    negative regulation of transcription from RNA polymerase II promoter IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of proteasomal ubiquitin-dependent protein catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of protein sumoylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of transcription, DNA-templated NAS
    Non-traceable Author Statement
    more info
    PubMed 
    post-translational protein modification TAS
    Traceable Author Statement
    more info
     
    protein sumoylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein sumoylation IEA
    Inferred from Electronic Annotation
    more info
     
    protein sumoylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    protein sumoylation TAS
    Traceable Author Statement
    more info
     
    regulation of cell proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of interferon-gamma-mediated signaling pathway TAS
    Traceable Author Statement
    more info
     
    transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    colocalizes_with PML body ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    nuclear speck IEA
    Inferred from Electronic Annotation
    more info
     
    nucleoplasm TAS
    Traceable Author Statement
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    E3 SUMO-protein ligase PIAS1
    Names
    AR interacting protein
    DEAD/H (Asp-Glu-Ala-Asp/His) box binding protein 1
    DEAD/H box-binding protein 1
    RNA helicase II-binding protein
    gu-binding protein
    protein inhibitor of activated STAT protein 1
    protein inhibitor of activated STAT, 1
    protein inhibitor of activated STAT-1
    zinc finger, MIZ-type containing 3

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_016166.1NP_057250.1  E3 SUMO-protein ligase PIAS1

      See identical proteins and their annotated locations for NP_057250.1

      Status: REVIEWED

      Source sequence(s)
      AF167160
      Consensus CDS
      CCDS45290.1
      UniProtKB/Swiss-Prot
      O75925
      Conserved Domains (3) summary
      pfam02891
      Location:331379
      zf-MIZ; MIZ/SP-RING zinc finger
      smart00513
      Location:1145
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      pfam14324
      Location:137286
      PINIT; PINIT domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p2 Primary Assembly

    Genomic

    1. NC_000015.10 Reference GRCh38.p2 Primary Assembly

      Range
      68054234..68191459
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011522127.1XP_011520429.1  

      Conserved Domains (3) summary
      pfam02891
      Location:325373
      zf-MIZ; MIZ/SP-RING zinc finger
      smart00513
      Location:539
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      pfam14324
      Location:131280
      PINIT; PINIT domain
    2. XM_011522128.1XP_011520430.1  

      See identical proteins and their annotated locations for XP_011520430.1

      UniProtKB/TrEMBL
      Q1XBU8
      Conserved Domains (3) summary
      pfam02891
      Location:322370
      zf-MIZ; MIZ/SP-RING zinc finger
      smart00513
      Location:236
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      pfam14324
      Location:128277
      PINIT; PINIT domain
    3. XM_011522126.1XP_011520428.1  

      Conserved Domains (3) summary
      pfam02891
      Location:340388
      zf-MIZ; MIZ/SP-RING zinc finger
      smart00513
      Location:2054
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      pfam14324
      Location:146295
      PINIT; PINIT domain
    4. XM_005254735.1XP_005254792.1  

      See identical proteins and their annotated locations for XP_005254792.1

      UniProtKB/TrEMBL
      Q1XBU8
      Conserved Domains (3) summary
      pfam02891
      Location:322370
      zf-MIZ; MIZ/SP-RING zinc finger
      smart00513
      Location:236
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      pfam14324
      Location:128277
      PINIT; PINIT domain

    Alternate CHM1_1.1

    Genomic

    1. NC_018926.2 Alternate CHM1_1.1

      Range
      68465362..68598367
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)