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PARP14 poly (ADP-ribose) polymerase family, member 14 [ Homo sapiens (human) ]

Gene ID: 54625, updated on 19-Jul-2014
Official Symbol
PARP14provided by HGNC
Official Full Name
poly (ADP-ribose) polymerase family, member 14provided by HGNC
Primary source
HGNC:29232
See related
Ensembl:ENSG00000173193; HPRD:11421; MIM:610028; Vega:OTTHUMG00000159552
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BAL2; ARTD8; pART8; PARP-14
Summary
Poly(ADP-ribosyl)ation is an immediate DNA damage-dependent posttranslational modification of histones and other nuclear proteins that contributes to the survival of injured proliferating cells. PARP14 belongs to the superfamily of enzymes that perform this modification (Ame et al., 2004 [PubMed 15273990]).[supplied by OMIM, Mar 2008]
See PARP14 in Epigenomics, MapViewer
Location:
3q21.1
Exon count:
18
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 3 NC_000003.12 (122680807..122730840)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (122399672..122449687)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene poly (ADP-ribose) polymerase family, member 14 pseudogene Neighboring gene poly (ADP-ribose) polymerase family, member 15 Neighboring gene eukaryotic translation initiation factor 4B pseudogene 8 Neighboring gene HSPB (heat shock 27kDa) associated protein 1 Neighboring gene disrupted in renal carcinoma 2

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • KIAA1268

Gene Ontology Provided by GOA

Function Evidence Code Pubs
NAD+ ADP-ribosyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
membrane IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
poly [ADP-ribose] polymerase 14
Names
poly [ADP-ribose] polymerase 14
collaborator of STAT6
B-aggressive lymphoma 2
b aggressive lymphoma protein 2
ADP-ribosyltransferase diphtheria toxin-like 8
NP_060024.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_017554.2NP_060024.2  poly [ADP-ribose] polymerase 14

    See proteins identical to NP_060024.2

    Status: VALIDATED

    Source sequence(s)
    AA890511, AB033094, AC048348, AC092908, AU117601, BC032804, BC039604, BU170133, CR977108, DC320673
    Consensus CDS
    CCDS46894.1
    UniProtKB/Swiss-Prot
    Q460N5
    UniProtKB/TrEMBL
    Q8N546
    Related
    ENSP00000418194, OTTHUMP00000215803, ENST00000474629, OTTHUMT00000356173
    Conserved Domains (5) summary
    cd01439
    Location:16791799
    Blast Score: 440
    TCCD_inducible_PARP_like; Poly(ADP-ribose) polymerases catalyse the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a regulatory component ...
    cd02903
    Location:10141155
    Blast Score: 499
    Macro_BAL_like; Macro domain, BAL_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). ...
    cd02907
    Location:801977
    Blast Score: 734
    Macro_Af1521_BAL_like; Macro domain, Af1521- and BAL-like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose ...
    cd12300
    Location:688
    Blast Score: 342
    RRM1_PAR14; RNA recognition motif 1 in vertebrate poly [ADP-ribose] polymerase 14 (PARP-14)
    cd12543
    Location:227301
    Blast Score: 297
    RRM2_PAR14; RNA recognition motif 2 in vertebrate poly [ADP-ribose] polymerase 14 (PARP-14)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000003.12 

    Range
    122680807..122730840
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005247545.1XP_005247602.1  

    Related
    ENSP00000420649, OTTHUMP00000215804, ENST00000460683, OTTHUMT00000356174
    Conserved Domains (4) summary
    cd01439
    Location:15431663
    Blast Score: 440
    TCCD_inducible_PARP_like; Poly(ADP-ribose) polymerases catalyse the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a regulatory component ...
    cd02903
    Location:8781019
    Blast Score: 497
    Macro_BAL_like; Macro domain, BAL_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). ...
    cd02907
    Location:665841
    Blast Score: 731
    Macro_Af1521_BAL_like; Macro domain, Af1521- and BAL-like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose ...
    cd12543
    Location:91165
    Blast Score: 297
    RRM2_PAR14; RNA recognition motif 2 in vertebrate poly [ADP-ribose] polymerase 14 (PARP-14)

RNA

  1. XR_427368.1 RNA Sequence

Alternate HuRef

Genomic

  1. AC_000135.1 

    Range
    119772932..119822958
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018914.2 

    Range
    122363227..122413244
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)