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    ZBTB16 zinc finger and BTB domain containing 16 [ Homo sapiens (human) ]

    Gene ID: 7704, updated on 24-Aug-2015
    Official Symbol
    ZBTB16provided by HGNC
    Official Full Name
    zinc finger and BTB domain containing 16provided by HGNC
    Primary source
    HGNC:HGNC:12930
    See related
    Ensembl:ENSG00000109906; HPRD:11762; MIM:176797; Vega:OTTHUMG00000168243
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PLZF; ZNF145
    Summary
    This gene is a member of the Krueppel C2H2-type zinc-finger protein family and encodes a zinc finger transcription factor that contains nine Kruppel-type zinc finger domains at the carboxyl terminus. This protein is located in the nucleus, is involved in cell cycle progression, and interacts with a histone deacetylase. Specific instances of aberrant gene rearrangement at this locus have been associated with acute promyelocytic leukemia (APL). Alternate transcriptional splice variants have been characterized. [provided by RefSeq, Jul 2008]
    Orthologs
    See ZBTB16 in Epigenomics, MapViewer
    Location:
    11q23.1
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    107 current GRCh38.p2 (GCF_000001405.28) 11 NC_000011.10 (114059579..114250676)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (113930289..114126702)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene 5-hydroxytryptamine (serotonin) receptor 3B, ionotropic Neighboring gene 5-hydroxytryptamine (serotonin) receptor 3A, ionotropic Neighboring gene uncharacterized LOC101928875 Neighboring gene nicotinamide N-methyltransferase Neighboring gene uncharacterized LOC101928940

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Associated conditions

    Description Tests
    Skeletal defects, genital hypoplasia, and mental retardation
    MedGen: C2676231 OMIM: 612447 GeneReviews: Not available
    Compare labs

    NHGRI GWAS Catalog

    Description
    Does parental expressed emotion moderate genetic effects in ADHD? An exploration using a genome wide association scan.
    NHGRI GWA Catalog

    Protein interactions

    Protein Gene Interaction Pubs
    Vif vif HIV-1 Vif downregulates the expression of zinc finger and BTB domain containing 16 (ZBTB16) in Vif-expression T cells PubMed

    Go to the HIV-1, Human Interaction Database

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    DNA binding NAS
    Non-traceable Author Statement
    more info
    PubMed 
    RNA polymerase II distal enhancer sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    double-stranded DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein C-terminus binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein domain specific binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    anterior/posterior pattern specification IEA
    Inferred from Electronic Annotation
    more info
     
    apoptotic process NAS
    Non-traceable Author Statement
    more info
    PubMed 
    cartilage development IDA
    Inferred from Direct Assay
    more info
    PubMed 
    central nervous system development ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    embryonic digit morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    embryonic hindlimb morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    embryonic pattern specification IEA
    Inferred from Electronic Annotation
    more info
     
    forelimb morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    hemopoiesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    hemopoiesis TAS
    Traceable Author Statement
    more info
    PubMed 
    male germ-line stem cell asymmetric division IEA
    Inferred from Electronic Annotation
    more info
     
    mesonephros development ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    myeloid cell differentiation TAS
    Traceable Author Statement
    more info
    PubMed 
    negative regulation of cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of myeloid cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    negative regulation of transcription from RNA polymerase II promoter IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of transcription, DNA-templated IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of transcription, DNA-templated NAS
    Non-traceable Author Statement
    more info
    PubMed 
    positive regulation of NK T cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of cartilage development IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of chondrocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of fat cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of ossification IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of transcription, DNA-templated IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein localization to nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
     
    transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    PML body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    nuclear body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nuclear speck IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleolus IDA
    Inferred from Direct Assay
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    transcriptional repressor complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    zinc finger and BTB domain-containing protein 16
    Names
    promyelocytic leukaemia zinc finger
    zinc finger protein 145 (Kruppel-like, expressed in promyelocytic leukemia)
    zinc finger protein PLZF

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_012140.1 RefSeqGene

      Range
      5001..195968
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001018011.1NP_001018011.1  zinc finger and BTB domain-containing protein 16

      See identical proteins and their annotated locations for NP_001018011.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      BC026902, BM969145
      Consensus CDS
      CCDS8367.1
      UniProtKB/TrEMBL
      A0A024R3C6
      UniProtKB/Swiss-Prot
      Q05516
      Related
      ENSP00000376721, OTTHUMP00000238382, ENST00000392996, OTTHUMT00000398944
      Conserved Domains (6) summary
      smart00355
      Location:518540
      ZnF_C2H2; zinc finger
      COG5048
      Location:448622
      COG5048; FOG: Zn-finger [General function prediction only]
      pfam00651
      Location:25125
      BTB; BTB/POZ domain
      pfam13465
      Location:561584
      zf-H2C2_2; Zinc-finger double domain
      sd00017
      Location:520540
      ZF_C2H2; Zn binding site [ion binding]
      sd00019
      Location:406426
      ZF_C2H2; Zn binding site [ion binding]
    2. NM_006006.4NP_005997.2  zinc finger and BTB domain-containing protein 16

      See identical proteins and their annotated locations for NP_005997.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      BC029812, BM969145, BX648973
      Consensus CDS
      CCDS8367.1
      UniProtKB/TrEMBL
      A0A024R3C6
      UniProtKB/Swiss-Prot
      Q05516
      Related
      ENSP00000338157, OTTHUMP00000238379, ENST00000335953, OTTHUMT00000398940
      Conserved Domains (6) summary
      smart00355
      Location:518540
      ZnF_C2H2; zinc finger
      COG5048
      Location:448622
      COG5048; FOG: Zn-finger [General function prediction only]
      pfam00651
      Location:25125
      BTB; BTB/POZ domain
      pfam13465
      Location:561584
      zf-H2C2_2; Zinc-finger double domain
      sd00017
      Location:520540
      ZF_C2H2; Zn binding site [ion binding]
      sd00019
      Location:406426
      ZF_C2H2; Zn binding site [ion binding]

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p2 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p2 Primary Assembly

      Range
      114059579..114250676
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011542971.1XP_011541273.1  

      Conserved Domains (3) summary
      pfam00651
      Location:25106
      BTB; BTB/POZ domain
      pfam13912
      Location:461483
      zf-C2H2_6; C2H2-type zinc finger
      sd00017
      Location:406426
      ZF_C2H2; Zn binding site [ion binding]
    2. XM_005271658.3XP_005271715.1  

      Conserved Domains (3) summary
      pfam00651
      Location:25106
      BTB; BTB/POZ domain
      pfam13912
      Location:461483
      zf-C2H2_6; C2H2-type zinc finger
      sd00017
      Location:406426
      ZF_C2H2; Zn binding site [ion binding]

    Alternate CHM1_1.1

    Genomic

    1. NC_018922.2 Alternate CHM1_1.1

      Range
      113814520..114005500
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)