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DROSHA drosha, ribonuclease type III [ Homo sapiens (human) ]

Gene ID: 29102, updated on 4-May-2015
Official Symbol
DROSHAprovided by HGNC
Official Full Name
drosha, ribonuclease type IIIprovided by HGNC
Primary source
HGNC:HGNC:17904
See related
Ensembl:ENSG00000113360; HPRD:10196; MIM:608828; Vega:OTTHUMG00000161976
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RN3; ETOHI2; RNASEN; RANSE3L; RNASE3L; HSA242976
Summary
Members of the ribonuclease III superfamily of double-stranded (ds) RNA-specific endoribonucleases participate in diverse RNA maturation and decay pathways in eukaryotic and prokaryotic cells (Fortin et al., 2002 [PubMed 12191433]). The RNase III Drosha is the core nuclease that executes the initiation step of microRNA (miRNA) processing in the nucleus (Lee et al., 2003 [PubMed 14508493]).[supplied by OMIM, Mar 2008]
Orthologs
See DROSHA in MapViewer
Location:
5p13.3
Exon count:
37
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 5 NC_000005.10 (31400494..31532175, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (31400601..31532282, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105374708 Neighboring gene uncharacterized LOC105374709 Neighboring gene cadherin 6, type 2, K-cadherin (fetal kidney) Neighboring gene chromosome 5 open reading frame 22 Neighboring gene PDZ domain containing 2 Neighboring gene ribosomal protein L9 pseudogene 17

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Protein interactions

Protein Gene Interaction Pubs
Pr55(Gag) gag Knockdown of Drosha by shRNA leads to inhibit enrichment of HIV-1 Gag in intracellular vacuoles, but enhance viral particle release in Gag expressing cells PubMed

Go to the HIV-1, Human Interaction Database

  • Direct p53 effectors, organism-specific biosystem (from Pathway Interaction Database)
    Direct p53 effectors, organism-specific biosystem
    Direct p53 effectors
  • Gene Expression, organism-specific biosystem (from REACTOME)
    Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
  • MicroRNA (miRNA) biogenesis, organism-specific biosystem (from REACTOME)
    MicroRNA (miRNA) biogenesis, organism-specific biosystemBiogenesis of microRNAs (miRNAs) can be summarized in five steps (reviewed in Ketting 2011, Nowotny and Yang 2009, Kim et al. 2009, Chua et al. 2009, Hannon and He 2004):1. Transcription. miRNA trans...
  • Proteoglycans in cancer, organism-specific biosystem (from KEGG)
    Proteoglycans in cancer, organism-specific biosystemMany proteoglycans (PGs) in the tumor microenvironment have been shown to be key macromolecules that contribute to biology of various types of cancer including proliferation, adhesion, angiogenesis a...
  • Proteoglycans in cancer, conserved biosystem (from KEGG)
    Proteoglycans in cancer, conserved biosystemMany proteoglycans (PGs) in the tumor microenvironment have been shown to be key macromolecules that contribute to biology of various types of cancer including proliferation, adhesion, angiogenesis a...
  • Regulatory RNA pathways, organism-specific biosystem (from REACTOME)
    Regulatory RNA pathways, organism-specific biosystemIn this module, the biology of various types of regulatory non-coding RNAs are described. Currently, biogenesis and functions of small interfering RNAs (siRNAs) and microRNAs are annotated.
  • Ribosome biogenesis in eukaryotes, organism-specific biosystem (from KEGG)
    Ribosome biogenesis in eukaryotes, organism-specific biosystemRibosomes are the cellular factories responsible for making proteins. In eukaryotes, ribosome biogenesis involves the production and correct assembly of four rRNAs and about 80 ribosomal proteins. It...
  • Ribosome biogenesis in eukaryotes, conserved biosystem (from KEGG)
    Ribosome biogenesis in eukaryotes, conserved biosystemRibosomes are the cellular factories responsible for making proteins. In eukaryotes, ribosome biogenesis involves the production and correct assembly of four rRNAs and about 80 ribosomal proteins. It...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
double-stranded RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
lipopolysaccharide binding IDA
Inferred from Direct Assay
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
poly(A) RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
primary miRNA binding NAS
Non-traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
ribonuclease III activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
RNA phosphodiester bond hydrolysis IDA
Inferred from Direct Assay
more info
PubMed 
RNA phosphodiester bond hydrolysis, endonucleolytic IDA
Inferred from Direct Assay
more info
PubMed 
RNA phosphodiester bond hydrolysis, endonucleolytic IEA
Inferred from Electronic Annotation
more info
 
defense response to Gram-negative bacterium IDA
Inferred from Direct Assay
more info
PubMed 
defense response to Gram-positive bacterium IDA
Inferred from Direct Assay
more info
PubMed 
gene expression TAS
Traceable Author Statement
more info
 
miRNA metabolic process IEA
Inferred from Electronic Annotation
more info
 
pre-miRNA processing IBA
Inferred from Biological aspect of Ancestor
more info
 
primary miRNA processing IDA
Inferred from Direct Assay
more info
PubMed 
primary miRNA processing IMP
Inferred from Mutant Phenotype
more info
PubMed 
production of siRNA involved in RNA interference IBA
Inferred from Biological aspect of Ancestor
more info
 
rRNA catabolic process IEA
Inferred from Electronic Annotation
more info
 
regulation of miRNA metabolic process IEA
Inferred from Electronic Annotation
more info
 
ribosome biogenesis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
microprocessor complex IDA
Inferred from Direct Assay
more info
PubMed 
nucleolus IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
Preferred Names
ribonuclease 3
Names
ribonuclease 3
RNase III
drosha, double-stranded RNA-specific endoribonuclease
nuclear RNase III Drosha
p241
protein Drosha
putative protein p241 which interacts with transcription factor Sp1
putative ribonuclease III
ribonuclease III, nuclear
ribonuclease type III, nuclear
NP_001093882.1
NP_037367.3

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001100412.1NP_001093882.1  ribonuclease 3 isoform 2

    See identical proteins and their annotated locations for NP_001093882.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. The resulting protein (isoform 2) is shorter than isoform 1.
    Source sequence(s)
    AA917625, AC008768, BC024261, BX647724, DB065470
    Consensus CDS
    CCDS47194.1
    UniProtKB/Swiss-Prot
    Q9NRR4
    Related
    ENSP00000424161, OTTHUMP00000220912, ENST00000513349, OTTHUMT00000366562
    Conserved Domains (4) summary
    PRK00102
    Location:10681296
    rnc; ribonuclease III; Reviewed
    cd00048
    Location:12231294
    DSRM; Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III, ...
    cd00593
    Location:10851217
    RIBOc; RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in ...
    pfam12871
    Location:209327
    PRP38_assoc; Pre-mRNA-splicing factor 38-associated hydrophilic C-term
  2. NM_013235.4NP_037367.3  ribonuclease 3 isoform 1

    See identical proteins and their annotated locations for NP_037367.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AA917625, AC008768, AF189011, BC024261, DB065470
    Consensus CDS
    CCDS47195.1
    UniProtKB/Swiss-Prot
    Q9NRR4
    Related
    ENSP00000425979, OTTHUMP00000220911, ENST00000511367, OTTHUMT00000366561
    Conserved Domains (4) summary
    PRK00102
    Location:11051333
    rnc; ribonuclease III; Reviewed
    cd00048
    Location:12601331
    DSRM; Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III, ...
    cd00593
    Location:11221254
    RIBOc; RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in ...
    pfam08648
    Location:217278
    DUF1777; Protein of unknown function (DUF1777)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p2 Primary Assembly

    Range
    31400494..31532175
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005248294.2XP_005248351.1  

    See identical proteins and their annotated locations for XP_005248351.1

    UniProtKB/Swiss-Prot
    Q9NRR4
    Conserved Domains (4) summary
    PRK00102
    Location:10371265
    rnc; ribonuclease III; Reviewed
    cd00048
    Location:11921263
    DSRM; Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III, ...
    cd00593
    Location:10541186
    RIBOc; RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in ...
    pfam12871
    Location:213286
    PRP38_assoc; Pre-mRNA-splicing factor 38-associated hydrophilic C-term
  2. XM_005248293.2XP_005248350.1  

    Conserved Domains (5) summary
    PRK00102
    Location:10741302
    rnc; ribonuclease III; Reviewed
    cd00048
    Location:12291300
    DSRM; Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III, ...
    cd00593
    Location:10911223
    RIBOc; RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in ...
    pfam08648
    Location:250369
    DUF1777; Protein of unknown function (DUF1777)
    pfam12871
    Location:213286
    PRP38_assoc; Pre-mRNA-splicing factor 38-associated hydrophilic C-term
  3. XM_005248292.2XP_005248349.1  

    Conserved Domains (4) summary
    PRK00102
    Location:10971325
    rnc; ribonuclease III; Reviewed
    cd00048
    Location:12521323
    DSRM; Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III, ...
    cd00593
    Location:11141246
    RIBOc; RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in ...
    pfam08648
    Location:217278
    DUF1777; Protein of unknown function (DUF1777)
  4. XM_005248291.2XP_005248348.1  

    See identical proteins and their annotated locations for XP_005248348.1

    UniProtKB/Swiss-Prot
    Q9NRR4
    Conserved Domains (4) summary
    PRK00102
    Location:11051333
    rnc; ribonuclease III; Reviewed
    cd00048
    Location:12601331
    DSRM; Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III, ...
    cd00593
    Location:11221254
    RIBOc; RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in ...
    pfam08648
    Location:217278
    DUF1777; Protein of unknown function (DUF1777)
  5. XM_011514033.1XP_011512335.1  

    Conserved Domains (2) summary
    cd00593
    Location:9591079
    RIBOc; RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in ...
    pfam12871
    Location:213302
    PRP38_assoc; Pre-mRNA-splicing factor 38-associated hydrophilic C-term

Alternate CHM1_1.1

Genomic

  1. NC_018916.2 Alternate CHM1_1.1

    Range
    31402053..31533647
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)