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    KRT2 keratin 2 [ Homo sapiens (human) ]

    Gene ID: 3849, updated on 8-Aug-2016
    Official Symbol
    KRT2provided by HGNC
    Official Full Name
    keratin 2provided by HGNC
    Primary source
    HGNC:HGNC:6439
    See related
    Ensembl:ENSG00000172867 HPRD:02560; MIM:600194; Vega:OTTHUMG00000169748
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    K2e; KRTE; CK-2e; KRT2A; KRT2E
    Summary
    The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is expressed largely in the upper spinous layer of epidermal keratinocytes and mutations in this gene have been associated with bullous congenital ichthyosiform erythroderma. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. [provided by RefSeq, Jul 2008]
    Orthologs
    Location:
    12q13.13
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 12 NC_000012.12 (52644558..52652175, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (53038342..53045959, complement)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105369772 Neighboring gene keratin 128 pseudogene Neighboring gene keratin 1 Neighboring gene keratin 77

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • MGC116967, MGC116968

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    structural constituent of cytoskeleton TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
     
    epidermis development TAS
    Traceable Author Statement
    more info
    PubMed 
    keratinization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    keratinocyte activation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    keratinocyte migration IDA
    Inferred from Direct Assay
    more info
    PubMed 
    keratinocyte proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    Golgi apparatus IDA
    Inferred from Direct Assay
    more info
     
    cytoplasm IDA
    Inferred from Direct Assay
    more info
     
    extracellular exosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    intermediate filament TAS
    Traceable Author Statement
    more info
    PubMed 
    intermediate filament cytoskeleton IDA
    Inferred from Direct Assay
    more info
     
    keratin filament IEA
    Inferred from Electronic Annotation
    more info
     
    membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    keratin, type II cytoskeletal 2 epidermal
    Names
    cytokeratin-2e
    epithelial keratin-2e
    keratin 2, type II
    keratin-2 epidermis
    keratin-2e
    type-II keratin Kb2

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_008296.1 RefSeqGene

      Range
      5001..12618
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_000423.2NP_000414.2  keratin, type II cytoskeletal 2 epidermal

      See identical proteins and their annotated locations for NP_000414.2

      Status: VALIDATED

      Source sequence(s)
      AL598277, BC096294, M99061
      Consensus CDS
      CCDS8835.1
      UniProtKB/Swiss-Prot
      P35908
      Related
      ENSP00000310861, OTTHUMP00000241990, ENST00000309680, OTTHUMT00000405704
      Conserved Domains (2) summary
      pfam00038
      Location:177490
      Filament; Intermediate filament protein
      pfam16208
      Location:150174
      Keratin_2_head; Keratin type II head

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p7 Primary Assembly

      Range
      52644558..52652175 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.1

    Genomic

    1. NC_018923.2 Alternate CHM1_1.1

      Range
      53005187..53012804 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)