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    TNFRSF8 TNF receptor superfamily member 8 [ Homo sapiens (human) ]

    Gene ID: 943, updated on 25-Aug-2016
    Official Symbol
    TNFRSF8provided by HGNC
    Official Full Name
    TNF receptor superfamily member 8provided by HGNC
    Primary source
    HGNC:HGNC:11923
    See related
    Ensembl:ENSG00000120949 HPRD:01074; MIM:153243; Vega:OTTHUMG00000001827
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CD30; Ki-1; D1S166E
    Summary
    The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is expressed by activated, but not by resting, T and B cells. TRAF2 and TRAF5 can interact with this receptor, and mediate the signal transduction that leads to the activation of NF-kappaB. This receptor is a positive regulator of apoptosis, and also has been shown to limit the proliferative potential of autoreactive CD8 effector T cells and protect the body against autoimmunity. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
    Orthologs
    Location:
    1p36
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 1 NC_000001.11 (12063318..12144213)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (12123434..12204264)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene migration and invasion inhibitory protein Neighboring gene microRNA 6729 Neighboring gene RNA, 7SL, cytoplasmic 649, pseudogene Neighboring gene RNA, U6 small nuclear 777, pseudogene Neighboring gene ribosomal protein L23a pseudogene 89 Neighboring gene TNF receptor superfamily member 1B Neighboring gene microRNA 7846 Neighboring gene microRNA 4632

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Protein interactions

    Protein Gene Interaction Pubs
    Nef nef Both HIV-1 Nef and Vpu downregulate the cell surface expression of tumor necrosis factor receptor superfamily, member 8 (TNFRSF8, CD30) PubMed
    Vif vif HIV-1 Vif upregulates the expression of tumor necrosis factor receptor superfamily, member 8 (TNFRSF8) in Vif-expression T cells PubMed
    Vpu vpu Both HIV-1 Nef and Vpu downregulate the cell surface expression of tumor necrosis factor receptor superfamily, member 8 (TNFRSF8, CD30) PubMed

    Go to the HIV-1, Human Interaction Database

    • Cytokine-cytokine receptor interaction, organism-specific biosystem (from KEGG)
      Cytokine-cytokine receptor interaction, organism-specific biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
    • Cytokine-cytokine receptor interaction, conserved biosystem (from KEGG)
      Cytokine-cytokine receptor interaction, conserved biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
    • TNF-alpha/NF-kB Signaling Pathway, organism-specific biosystem (from WikiPathways)
      TNF-alpha/NF-kB Signaling Pathway, organism-specific biosystem"The Tumor Necrosis Factor alpha is a proinflammatory cytokine belonging to the TNF superfamily. It signals through 2 separate receptors - TNFRSF1A and TNFRSF1B, both members of the TNF receptor supe...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    transmembrane signaling receptor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    tumor necrosis factor-activated receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    apoptotic signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    cellular response to mechanical stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    inflammatory response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    multicellular organism development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    negative regulation of cell proliferation TAS
    Traceable Author Statement
    more info
    PubMed 
    positive regulation of TRAIL biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of tumor necrosis factor biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    response to lipopolysaccharide IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    tumor necrosis factor-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular exosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    integral component of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Preferred Names
    tumor necrosis factor receptor superfamily member 8
    Names
    CD30L receptor
    Ki-1 antigen
    cytokine receptor CD30
    lymphocyte activation antigen CD30
    tumor necrosis factor receptor superfamily, member 8

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029573.2 RefSeqGene

      Range
      5001..85831
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001243.4NP_001234.3  tumor necrosis factor receptor superfamily member 8 isoform 1 precursor

      See identical proteins and their annotated locations for NP_001234.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AL357835, BC136400, BC141804, M83554
      Consensus CDS
      CCDS144.1
      UniProtKB/Swiss-Prot
      P28908
      UniProtKB/TrEMBL
      A5D8T4
      Related
      ENSP00000263932, OTTHUMP00000001783, ENST00000263932, OTTHUMT00000005130
      Conserved Domains (1) summary
      cd13409
      Location:17131
      TNFRSF8; Tumor necrosis factor receptor superfamily member 8 (TNFRSF8), also known as CD30
    2. NM_001281430.2NP_001268359.2  tumor necrosis factor receptor superfamily member 8 isoform 3

      See identical proteins and their annotated locations for NP_001268359.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) has multiple differences, compared to variant 1. These differences result in a distinct 5' UTR and cause translation initiation at a downstream start codon, compared to variant 1. The encoded protein (isoform 3) is shorter than isoform 1.
      Source sequence(s)
      AL357835, BC136400, BC141804, M83554
      Consensus CDS
      CCDS59989.1
      UniProtKB/Swiss-Prot
      P28908
      UniProtKB/TrEMBL
      A5D8T4
      Related
      ENSP00000390650, ENST00000417814
      Conserved Domains (2) summary
      cd13409
      Location:62195
      TNFRSF8; Tumor necrosis factor receptor superfamily member 8 (TNFRSF8), also known as CD30
      cl22855
      Location:120
      TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p7 Primary Assembly

      Range
      12063318..12144213
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011542441.2XP_011540743.1  

      Conserved Domains (1) summary
      cd13409
      Location:17131
      TNFRSF8; Tumor necrosis factor receptor superfamily member 8 (TNFRSF8), also known as CD30
    2. XM_011542443.2XP_011540745.1  

      Conserved Domains (2) summary
      cd13409
      Location:62195
      TNFRSF8; Tumor necrosis factor receptor superfamily member 8 (TNFRSF8), also known as CD30
      cl22855
      Location:120
      TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)

    Alternate CHM1_1.1

    Genomic

    1. NC_018912.2 Alternate CHM1_1.1

      Range
      12111329..12192169
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_152942.2: Suppressed sequence

      Description
      NM_152942.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.