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RCC2 regulator of chromosome condensation 2 [ Homo sapiens (human) ]

Gene ID: 55920, updated on 7-Dec-2014
Official Symbol
RCC2provided by HGNC
Official Full Name
regulator of chromosome condensation 2provided by HGNC
Primary source
HGNC:HGNC:30297
See related
Ensembl:ENSG00000179051; HPRD:18171; MIM:609587; Vega:OTTHUMG00000002513
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TD-60
See RCC2 in Epigenomics, MapViewer
Location:
1p36.13
Exon count:
13
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 1 NC_000001.11 (17406755..17439754, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (17733251..17766250, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene peptidyl arginine deiminase, type IV Neighboring gene peptidyl arginine deiminase, type VI Neighboring gene uncharacterized LOC102723454 Neighboring gene Rho guanine nucleotide exchange factor (GEF) 10-like

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Common variants on 1p36 and 1q42 are associated with cutaneous basal cell carcinoma but not with melanoma or pigmentation traits.
NHGRI GWA Catalog
Germline sequence variants in TGM3 and RGS22 confer risk of basal cell carcinoma.
NHGRI GWA Catalog

Protein interactions

Protein Gene Interaction Pubs
retropepsin gag-pol Positional proteomics analysis identifies the cleavage of human regulator of chromosome condensation 2 (RCC2) at amino acid residues 56-57 by the HIV-1 protease PubMed

Go to the HIV-1, Human Interaction Database

  • Cell Cycle, organism-specific biosystem (from REACTOME)
    Cell Cycle, organism-specific biosystem
    Cell Cycle
  • Cell Cycle, Mitotic, organism-specific biosystem (from REACTOME)
    Cell Cycle, Mitotic, organism-specific biosystemThe replication of the genome and the subsequent segregation of chromosomes into daughter cells are controlled by a series of events collectively known as the cell cycle. DNA replication is carried o...
  • M Phase, organism-specific biosystem (from REACTOME)
    M Phase, organism-specific biosystemMitosis, or the M phase, involves nuclear division and cytokinesis, where two identical daughter cells are produced. Mitosis involves prophase, prometaphase, metaphase, anaphase, and telophase. Fin...
  • Mitotic Anaphase, organism-specific biosystem (from REACTOME)
    Mitotic Anaphase, organism-specific biosystemIn anaphase, the paired chromosomes separate at the centromeres, and move to the opposite sides of the cell. The movement of the chromosomes is facilitated by a combination of kinetochore movement al...
  • Mitotic Metaphase and Anaphase, organism-specific biosystem (from REACTOME)
    Mitotic Metaphase and Anaphase, organism-specific biosystemMetaphase is marked by the formation of the metaphase plate. The metaphase plate is formed when the spindle fibers align the chromosomes along the middle of the cell. Such an organization helps to ...
  • Mitotic Prometaphase, organism-specific biosystem (from REACTOME)
    Mitotic Prometaphase, organism-specific biosystemThe dissolution of the nuclear membrane marks the beginning of the prometaphase. Kinetochores are created when proteins attach to the centromeres. Microtubules then attach at the kinetochores, and th...
  • Resolution of Sister Chromatid Cohesion, organism-specific biosystem (from REACTOME)
    Resolution of Sister Chromatid Cohesion, organism-specific biosystemThe resolution of sister chromatids in mitotic prometaphase involves removal of cohesin complexes from chromosomal arms, with preservation of cohesion at centromeres (Losada et al. 1998, Hauf et al. ...
  • Separation of Sister Chromatids, organism-specific biosystem (from REACTOME)
    Separation of Sister Chromatids, organism-specific biosystemWhile sister chromatids resolve in prometaphase, separating along chromosomal arms, the cohesion of sister centromeres persists until anaphase. At the anaphase onset, the anaphase promoting complex/c...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • KIAA1470, DKFZp762N0610

Gene Ontology Provided by GOA

Function Evidence Code Pubs
Rac GTPase binding IPI
Inferred from Physical Interaction
more info
PubMed 
microtubule binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
poly(A) RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cell division IEA
Inferred from Electronic Annotation
more info
 
chromosome passenger complex localization to kinetochore IMP
Inferred from Mutant Phenotype
more info
PubMed 
endosome organization IEA
Inferred from Electronic Annotation
more info
 
focal adhesion assembly IDA
Inferred from Direct Assay
more info
PubMed 
integrin-mediated signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
mitotic cell cycle TAS
Traceable Author Statement
more info
 
mitotic nuclear division IEA
Inferred from Electronic Annotation
more info
 
negative regulation of GTPase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of focal adhesion assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of substrate adhesion-dependent cell spreading ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of G2/M transition of mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of attachment of spindle microtubules to kinetochore IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of cell migration ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
chromosome, centromeric core domain IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
microtubule IEA
Inferred from Electronic Annotation
more info
 
midbody IDA
Inferred from Direct Assay
more info
PubMed 
mitotic spindle midzone IDA
Inferred from Direct Assay
more info
PubMed 
nucleolus IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
protein RCC2
Names
protein RCC2
RCC1-like protein TD-60
telophase disk protein of 60 kDa

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001136204.2NP_001129676.1  protein RCC2

    See proteins identical to NP_001129676.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AB040903, BC004933, BC053908, BQ774471, CR991144
    Consensus CDS
    CCDS181.1
    UniProtKB/TrEMBL
    A0A024RAC5
    UniProtKB/Swiss-Prot
    Q9P258
    Conserved Domains (2) summary
    pfam00415
    Location:168217
    RCC1; Regulator of chromosome condensation (RCC1) repeat
    pfam13540
    Location:150181
    RCC1_2; Regulator of chromosome condensation (RCC1) repeat
  2. NM_018715.3NP_061185.1  protein RCC2

    See proteins identical to NP_061185.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AB040903, BC004933, BQ774471, DR000303
    Consensus CDS
    CCDS181.1
    UniProtKB/TrEMBL
    A0A024RAC5
    UniProtKB/Swiss-Prot
    Q9P258
    Related
    ENSP00000364585, OTTHUMP00000002613, ENST00000375436, OTTHUMT00000007144
    Conserved Domains (2) summary
    pfam00415
    Location:168217
    RCC1; Regulator of chromosome condensation (RCC1) repeat
    pfam13540
    Location:150181
    RCC1_2; Regulator of chromosome condensation (RCC1) repeat

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000001.11 

    Range
    17406755..17439754
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018912.2 

    Range
    17841584..17874664
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

  1. AC_000133.1 

    Range
    15979184..16012475
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)