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    DPAGT1 dolichyl-phosphate N-acetylglucosaminephosphotransferase 1 [ Homo sapiens (human) ]

    Gene ID: 1798, updated on 25-Aug-2016
    Official Symbol
    DPAGT1provided by HGNC
    Official Full Name
    dolichyl-phosphate N-acetylglucosaminephosphotransferase 1provided by HGNC
    Primary source
    HGNC:HGNC:2995
    See related
    Ensembl:ENSG00000172269 HPRD:01879; MIM:191350; Vega:OTTHUMG00000153533
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GPT; ALG7; DGPT; G1PT; UAGT; UGAT; CDG1J; CMS13; DPAGT; CDG-Ij; CMSTA2; DPAGT2; D11S366
    Summary
    The protein encoded by this gene is an enzyme that catalyzes the first step in the dolichol-linked oligosaccharide pathway for glycoprotein biosynthesis. This enzyme belongs to the glycosyltransferase family 4. This protein is an integral membrane protein of the endoplasmic reticulum. The congenital disorder of glycosylation type Ij is caused by mutation in the gene encoding this enzyme. [provided by RefSeq, Jul 2008]
    Orthologs
    Location:
    11q23.3
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 11 NC_000011.10 (119096503..119102414, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (118967213..118973124, complement)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene hydroxymethylbilane synthase Neighboring gene H2A histone family member X Neighboring gene uncharacterized LOC107984397 Neighboring gene C2CD2 like Neighboring gene histone H4 transcription factor

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    UDP-N-acetylglucosamine metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    dolichol biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    dolichol-linked oligosaccharide biosynthetic process TAS
    Traceable Author Statement
    more info
     
    protein N-linked glycosylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein oligomerization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    endoplasmic reticulum membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    endoplasmic reticulum membrane TAS
    Traceable Author Statement
    more info
     
    integral component of endoplasmic reticulum membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    integral component of endoplasmic reticulum membrane NAS
    Non-traceable Author Statement
    more info
    PubMed 
    integral component of membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase
    Names
    GlcNAc-1-P transferase
    GlcNAc-1-P transferase 1
    N-acetylglucosamine-1-phosphate transferase
    UDP-GlcNAc:dolichyl-phosphate N-acetylglucosaminephosphotransferase
    UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase 1
    dolichyl-phosphate (UDP-N-acetylglucosamine) N-acetylglucosaminephosphotransferase 1 (GlcNAc-1-P tra
    dolichyl-phosphate (UDP-N-acetylglucosamine) N-acetylglucosaminephosphotransferase 1 (GlcNAc-1-P transferase)
    dolichyl-phosphate alpha-N-acetylglucosaminyltransferase
    NP_001373.2

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_008918.1 RefSeqGene

      Range
      5001..10573
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001382.3NP_001373.2  UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase

      See identical proteins and their annotated locations for NP_001373.2

      Status: REVIEWED

      Source sequence(s)
      AA833740, BC000325, DA023424
      Consensus CDS
      CCDS8411.1
      UniProtKB/Swiss-Prot
      Q9H3H5
      UniProtKB/TrEMBL
      A0A024R3H8
      Related
      ENSP00000346142, OTTHUMP00000204052, ENST00000354202, OTTHUMT00000331522
      Conserved Domains (1) summary
      cd06855
      Location:29317
      GT_GPT_euk; UDP-GlcNAc:dolichol-P GlcNAc-1-P transferase (GPT) catalyzes the transfer of GlcNAc-1-P from UDP-GlcNAc to dolichol-P to form GlcNAc-P-P-dolichol. The reaction is the first step in the assembly of dolichol-linked oligosaccharide intermediates and is ...

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p7 Primary Assembly

      Range
      119096503..119102414 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017017293.1XP_016872782.1  

    2. XM_011542648.1XP_011540950.1  

      Conserved Domains (1) summary
      cd06855
      Location:1210
      GT_GPT_euk; UDP-GlcNAc:dolichol-P GlcNAc-1-P transferase (GPT) catalyzes the transfer of GlcNAc-1-P from UDP-GlcNAc to dolichol-P to form GlcNAc-P-P-dolichol. The reaction is the first step in the assembly of dolichol-linked oligosaccharide intermediates and is ...
    3. XM_017017294.1XP_016872783.1  

    4. XM_005271422.2XP_005271479.1  

      Conserved Domains (1) summary
      cd06855
      Location:29317
      GT_GPT_euk; UDP-GlcNAc:dolichol-P GlcNAc-1-P transferase (GPT) catalyzes the transfer of GlcNAc-1-P from UDP-GlcNAc to dolichol-P to form GlcNAc-P-P-dolichol. The reaction is the first step in the assembly of dolichol-linked oligosaccharide intermediates and is ...
    5. XM_017017295.1XP_016872784.1  

    RNA

    1. XR_001747786.1 RNA Sequence

    2. XR_947801.1 RNA Sequence

      Related
      ENST00000414373, OTTHUMT00000331525
    3. XR_001747785.1 RNA Sequence

    4. XR_001747784.1 RNA Sequence

      Related
      ENST00000392834, OTTHUMT00000331523

    Alternate CHM1_1.1

    Genomic

    1. NC_018922.2 Alternate CHM1_1.1

      Range
      118853515..118859087 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_203316.1: Suppressed sequence

      Description
      NM_203316.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.