Format

Send to:

Choose Destination

Links from PubMed

    • Showing Current items.

    TRPA1 transient receptor potential cation channel subfamily A member 1 [ Homo sapiens (human) ]

    Gene ID: 8989, updated on 9-Jun-2016
    Official Symbol
    TRPA1provided by HGNC
    Official Full Name
    transient receptor potential cation channel subfamily A member 1provided by HGNC
    Primary source
    HGNC:HGNC:497
    See related
    Ensembl:ENSG00000104321 HPRD:09208; MIM:604775; Vega:OTTHUMG00000164516
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FEPS; ANKTM1
    Summary
    The structure of the protein encoded by this gene is highly related to both the protein ankyrin and transmembrane proteins. The specific function of this protein has not yet been determined; however, studies indicate the function may involve a role in signal transduction and growth control. [provided by RefSeq, Jul 2008]
    Orthologs
    Location:
    8q13
    Exon count:
    29
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 8 NC_000008.11 (72021251..72094885, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (72933486..72987819, complement)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene MSC antisense RNA 1 Neighboring gene musculin Neighboring gene ribosomal protein S20 pseudogene 20 Neighboring gene uncharacterized LOC105375896 Neighboring gene transient receptor potential cation channel subfamily A member 1 pseudogene Neighboring gene RNA, 5S ribosomal pseudogene 271

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    • Inflammatory mediator regulation of TRP channels, organism-specific biosystem (from KEGG)
      Inflammatory mediator regulation of TRP channels, organism-specific biosystemThe TRP channels that exhibit a unique response to temperature have been given the name thermo-TRPs. Among all thermo- TRP channels, TRPV1-4, TRPM8, and TRPA1 are expressed in subsets of nociceptive...
    • Inflammatory mediator regulation of TRP channels, conserved biosystem (from KEGG)
      Inflammatory mediator regulation of TRP channels, conserved biosystemThe TRP channels that exhibit a unique response to temperature have been given the name thermo-TRPs. Among all thermo- TRP channels, TRPV1-4, TRPM8, and TRPA1 are expressed in subsets of nociceptive...
    • Ion channel transport, organism-specific biosystem (from REACTOME)
      Ion channel transport, organism-specific biosystemIon channels mediate the flow of ions across the plasma membrane of cells. They are integral membrane proteins, typically a multimer of proteins, which, when arranged in the membrane, create a pore f...
    • Stimuli-sensing channels, organism-specific biosystem (from REACTOME)
      Stimuli-sensing channels, organism-specific biosystemIon channels that mediate sensations such as pain, warmth, cold, taste pressure and vision. Channels that mediate these sensations include acid-sensing ion channels (ASICs) (Wang & Xu 2011, Qadri et ...
    • TRP channels, organism-specific biosystem (from REACTOME)
      TRP channels, organism-specific biosystemTransient receptor potential (TRP) channel proteins were first discovered in Drosophila melanogaster and have many homologues in other species including humans. TRPs form cationic channels that can ...
    • Transmembrane transport of small molecules, organism-specific biosystem (from REACTOME)
      Transmembrane transport of small molecules, organism-specific biosystem
      Transmembrane transport of small molecules
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    calcium channel activity TAS
    Traceable Author Statement
    more info
     
    calcium-release channel activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    calcium-release channel activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    channel activity TAS
    Traceable Author Statement
    more info
    PubMed 
    temperature-gated cation channel activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    calcium ion transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    calcium ion transmembrane transport TAS
    Traceable Author Statement
    more info
     
    cell surface receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    detection of chemical stimulus involved in sensory perception of pain IEA
    Inferred from Electronic Annotation
    more info
     
    detection of mechanical stimulus involved in sensory perception of pain IEA
    Inferred from Electronic Annotation
    more info
     
    ion transport TAS
    Traceable Author Statement
    more info
    PubMed 
    protein homotetramerization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    release of sequestered calcium ion into cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    response to cold IEA
    Inferred from Electronic Annotation
    more info
     
    response to drug IEA
    Inferred from Electronic Annotation
    more info
     
    response to hydrogen peroxide IEA
    Inferred from Electronic Annotation
    more info
     
    response to organic cyclic compound IEA
    Inferred from Electronic Annotation
    more info
     
    response to organic substance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to pain IEA
    Inferred from Electronic Annotation
    more info
     
    sensory perception of pain IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    thermoception IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    integral component of plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    intracellular IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane TAS
    Traceable Author Statement
    more info
     
    stereocilium bundle IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    transient receptor potential cation channel subfamily A member 1
    Names
    ankyrin-like with transmembrane domains 1
    transformation-sensitive protein p120
    transient receptor potential cation channel, subfamily A, member 1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_033890.1 RefSeqGene

      Range
      5001..59334
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_007332.2NP_015628.2  transient receptor potential cation channel subfamily A member 1

      See identical proteins and their annotated locations for NP_015628.2

      Status: REVIEWED

      Source sequence(s)
      AC016057, AC022867
      Consensus CDS
      CCDS34908.1
      UniProtKB/Swiss-Prot
      O75762
      Related
      ENSP00000262209, OTTHUMP00000226879, ENST00000262209, OTTHUMT00000379079
      Conserved Domains (4) summary
      cd00204
      Location:95218
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam00520
      Location:796959
      Ion_trans; Ion transport protein
      pfam12796
      Location:486577
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:274329
      Ank_4; Ankyrin repeats (many copies)

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p7 Primary Assembly

      Range
      72021251..72094885 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011517624.2XP_011515926.1  

      Conserved Domains (4) summary
      cd00204
      Location:120243
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam00520
      Location:821984
      Ion_trans; Ion transport protein
      pfam12796
      Location:511602
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:299354
      Ank_4; Ankyrin repeats (many copies)
    2. XM_011517625.2XP_011515927.1  

      See identical proteins and their annotated locations for XP_011515927.1

      UniProtKB/Swiss-Prot
      O75762
      Conserved Domains (4) summary
      cd00204
      Location:95218
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam00520
      Location:796959
      Ion_trans; Ion transport protein
      pfam12796
      Location:486577
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:274329
      Ank_4; Ankyrin repeats (many copies)
    3. XM_017013946.1XP_016869435.1  

    Alternate CHM1_1.1

    Genomic

    1. NC_018919.2 Alternate CHM1_1.1

      Range
      72986840..73041189 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)