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SLPI secretory leukocyte peptidase inhibitor [ Homo sapiens (human) ]

Gene ID: 6590, updated on 4-May-2015
Official Symbol
SLPIprovided by HGNC
Official Full Name
secretory leukocyte peptidase inhibitorprovided by HGNC
Primary source
HGNC:HGNC:11092
See related
Ensembl:ENSG00000124107; HPRD:00121; MIM:107285; Vega:OTTHUMG00000033075
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ALP; MPI; ALK1; BLPI; HUSI; WAP4; WFDC4; HUSI-I
Summary
This gene encodes a secreted inhibitor which protects epithelial tissues from serine proteases. It is found in various secretions including seminal plasma, cervical mucus, and bronchial secretions, and has affinity for trypsin, leukocyte elastase, and cathepsin G. Its inhibitory effect contributes to the immune response by protecting epithelial surfaces from attack by endogenous proteolytic enzymes. This antimicrobial protein has antibacterial, antifungal and antiviral activity. [provided by RefSeq, Nov 2014]
Orthologs
See SLPI in MapViewer
Location:
20q12
Exon count:
4
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 20 NC_000020.11 (45252239..45254564, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (43880880..43883205, complement)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene semenogelin I Neighboring gene uncharacterized LOC105372630 Neighboring gene semenogelin II Neighboring gene matrilin 4 Neighboring gene recombination signal binding protein for immunoglobulin kappa J region-like Neighboring gene transfer RNA-Val (CAC) 14-1

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env The expression and production of secretory leukocyte protease inhibitor (SLPI), a 12-kDa mucosal antiviral protein, can be stimulated in oral epithelial cells through interactions with HIV-1 gp120 PubMed
retropepsin gag-pol Secretory levels of secretory leukocyte peptidase inhibitor (SLPI) from HIV-1 infected patients is enhanced in saliva PubMed
gag-pol Human secretory leukocyte protease inhibitor (hSLPI) inhibits HIV-1 infection of lymphocyte- and monocyte-derived tumor cell lines and peripheral blood lymphocytes PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
endopeptidase inhibitor activity TAS
Traceable Author Statement
more info
PubMed 
enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
serine-type endopeptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
negative regulation of endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
negative regulation of protein binding IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of viral genome replication IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
extracellular exosome IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with extracellular matrix IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
antileukoproteinase
Names
antileukoproteinase
HUSI-1
WAP four-disulfide core domain protein 4
mucus proteinase inhibitor
protease inhibitor WAP4
secretory leukocyte protease inhibitor (antileukoproteinase)
seminal proteinase inhibitor

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_028137.1 RefSeqGene

    Range
    5002..7327
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_003064.3NP_003055.1  antileukoproteinase precursor

    See identical proteins and their annotated locations for NP_003055.1

    Status: REVIEWED

    Source sequence(s)
    BC020708
    Consensus CDS
    CCDS13347.1
    UniProtKB/Swiss-Prot
    P03973
    Related
    ENSP00000342082, OTTHUMP00000031775, ENST00000338380, OTTHUMT00000080494
    Conserved Domains (2) summary
    cd00199
    Location:80130
    WAP; whey acidic protein-type four-disulfide core domains. Members of the family include whey acidic protein, elafin (elastase-specific inhibitor), caltrin-like protein (a calcium transport inhibitor) and other extracellular proteinase inhibitors. A group of ...
    pfam00095
    Location:3175
    WAP; WAP-type (Whey Acidic Protein) 'four-disulfide core'

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p2 Primary Assembly

    Range
    45252239..45254564
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018931.2 Alternate CHM1_1.1

    Range
    43783432..43785757
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)