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NR4A2 nuclear receptor subfamily 4, group A, member 2 [ Homo sapiens (human) ]

Gene ID: 4929, updated on 6-Jul-2014
Official Symbol
NR4A2provided by HGNC
Official Full Name
nuclear receptor subfamily 4, group A, member 2provided by HGNC
Primary source
HGNC:7981
See related
Ensembl:ENSG00000153234; HPRD:03493; MIM:601828; Vega:OTTHUMG00000131950
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NOT; RNR1; HZF-3; NURR1; TINUR
Summary
This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. The encoded protein may act as a transcription factor. Mutations in this gene have been associated with disorders related to dopaminergic dysfunction, including Parkinson disease, schizophernia, and manic depression. Misregulation of this gene may be associated with rheumatoid arthritis. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]
See NR4A2 in Epigenomics, MapViewer
Location:
2q22-q23
Exon count :
8
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 2 NC_000002.12 (156324432..156332775, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (157180944..157189287, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101929378 Neighboring gene heme binding protein 2 pseudogene Neighboring gene transfer RNA-Ala (CGC) 3-1 Neighboring gene transfer RNA-Gly (GCC) 2-5

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Associated conditions

Description Tests
Parkinson's disease Compare labs

NHGRI GWAS Catalog

Description
Genome-wide association of lipid-lowering response to statins in combined study populations.
NHGRI GWA Catalog
Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies.
NHGRI GWA Catalog

Replication interactions

Interaction Pubs
Knockdown of nuclear receptor subfamily 4, group A, member 2 (NR4A2) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Vif, p23 vif HIV-1 Vif upregulates the expression of nuclear receptor subfamily 4, group A, member 2 (NR4A2) in Vif-expression T cells PubMed

Go to the HIV-1, Human Protein Interaction Database

  • Corticotropin-releasing hormone, organism-specific biosystem (from WikiPathways)
    Corticotropin-releasing hormone, organism-specific biosystemCorticotropin-releasing hormone (CRH) is a neuropeptide secreted abundantly in the paraventricular nucleus of the hypothalamus, amygdala, cerebral cortex and cerebellum in the central nervous system ...
  • Gene Expression, organism-specific biosystem (from REACTOME)
    Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
  • Generic Transcription Pathway, organism-specific biosystem (from REACTOME)
    Generic Transcription Pathway, organism-specific biosystemOVERVIEW OF TRANSCRIPTION REGULATION: Detailed studies of gene transcription regulation in a wide variety of eukaryotic systems has revealed the general principles and mechanisms by which cell- or t...
  • Nuclear Receptor transcription pathway, organism-specific biosystem (from REACTOME)
    Nuclear Receptor transcription pathway, organism-specific biosystemA classic example of bifunctional transcription factors is the family of Nuclear Receptor (NR) proteins. These are DNA-binding transcription factors that bind certain hormones, vitamins, and other s...
  • Nuclear Receptors, organism-specific biosystem (from WikiPathways)
    Nuclear Receptors, organism-specific biosystemNuclear receptors are a class of proteins found within the interior of cells that are responsible for sensing the presence of steroid and thyroid hormones and certain other molecules. In response, th...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
 
protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
 
sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 
steroid hormone receptor activity IEA
Inferred from Electronic Annotation
more info
 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
adult locomotory behavior IEA
Inferred from Electronic Annotation
more info
 
cellular response to extracellular stimulus IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to oxidative stress IEA
Inferred from Electronic Annotation
more info
 
central nervous system projection neuron axonogenesis IEA
Inferred from Electronic Annotation
more info
 
death IEA
Inferred from Electronic Annotation
more info
 
dopamine biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
dopaminergic neuron differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
gene expression TAS
Traceable Author Statement
more info
 
general adaptation syndrome IEA
Inferred from Electronic Annotation
more info
 
habenula development IEA
Inferred from Electronic Annotation
more info
 
intracellular receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
intracellular receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
negative regulation of neuron apoptotic process IEA
Inferred from Electronic Annotation
more info
 
neuron maturation IEA
Inferred from Electronic Annotation
more info
 
neuron migration IEA
Inferred from Electronic Annotation
more info
 
positive regulation of catalytic activity IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transcription from RNA polymerase II promoter IEA
Inferred from Electronic Annotation
more info
 
post-embryonic development IEA
Inferred from Electronic Annotation
more info
 
regulation of dopamine metabolic process IEA
Inferred from Electronic Annotation
more info
 
regulation of respiratory gaseous exchange IEA
Inferred from Electronic Annotation
more info
 
response to amphetamine IEA
Inferred from Electronic Annotation
more info
 
response to hypoxia IEA
Inferred from Electronic Annotation
more info
 
response to inorganic substance IEA
Inferred from Electronic Annotation
more info
 
response to insecticide IEA
Inferred from Electronic Annotation
more info
 
signal transduction NAS
Non-traceable Author Statement
more info
PubMed 
steroid hormone mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
transcription initiation from RNA polymerase II promoter TAS
Traceable Author Statement
more info
 
transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
nuclear receptor subfamily 4 group A member 2
Names
nuclear receptor subfamily 4 group A member 2
nuclear receptor related 1
T-cell nuclear receptor NOT
orphan nuclear receptor NR4A2
orphan nuclear receptor NURR1
intermediate-early receptor protein
immediate-early response protein NOT
nur related protein-1, human homolog of
transcriptionally-inducible nuclear receptor
NGFI-B/nur77 beta-type transcription factor homolog
transcriptionally inducible nuclear receptor related 1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_011821.1 

    Range
    5001..13344
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_006186.3NP_006177.1  nuclear receptor subfamily 4 group A member 2

    See proteins identical to NP_006177.1

    Status: REVIEWED

    Source sequence(s)
    AK223625, DA093733, X75918
    Consensus CDS
    CCDS2201.1
    UniProtKB/TrEMBL
    F1D8N6
    UniProtKB/Swiss-Prot
    P43354
    UniProtKB/TrEMBL
    Q53EL4
    Related
    ENSP00000344479, OTTHUMP00000162787, ENST00000339562, OTTHUMT00000254909
    Conserved Domains (2) summary
    cd07071
    Location:361598
    Blast Score: 1305
    NR_LBD_Nurr1; The ligand binding domain of Nurr1, a member of conserved family of nuclear receptors
    cd06969
    Location:261335
    Blast Score: 468
    NR_DBD_NGFI-B; DNA-binding domain of the orphan nuclear receptor, nerve growth factor-induced-B

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000002.12 

    Range
    156324432..156332775
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005246622.1XP_005246679.1  

    See proteins identical to XP_005246679.1

    UniProtKB/TrEMBL
    Q6NXU0
    Related
    ENSP00000389986, OTTHUMP00000209447, ENST00000426264, OTTHUMT00000332640
    Conserved Domains (2) summary
    cd07071
    Location:298535
    Blast Score: 1305
    NR_LBD_Nurr1; The ligand binding domain of Nurr1, a member of conserved family of nuclear receptors
    cd06969
    Location:198272
    Blast Score: 462
    NR_DBD_NGFI-B; DNA-binding domain of the orphan nuclear receptor, nerve growth factor-induced-B
  2. XM_005246623.1XP_005246680.1  

    See proteins identical to XP_005246680.1

    UniProtKB/TrEMBL
    Q6NXU0
    Conserved Domains (2) summary
    cd07071
    Location:298535
    Blast Score: 1305
    NR_LBD_Nurr1; The ligand binding domain of Nurr1, a member of conserved family of nuclear receptors
    cd06969
    Location:198272
    Blast Score: 462
    NR_DBD_NGFI-B; DNA-binding domain of the orphan nuclear receptor, nerve growth factor-induced-B
  3. XM_006712553.1XP_006712616.1  

    Conserved Domains (2) summary
    cd06969
    Location:272346
    Blast Score: 466
    NR_DBD_NGFI-B; DNA-binding domain of the orphan nuclear receptor, nerve growth factor-induced-B
    cl11397
    Location:373584
    Blast Score: 1170
    NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators
  4. XM_005246621.1XP_005246678.1  

    UniProtKB/TrEMBL
    F5H4G9
    Conserved Domains (2) summary
    cd07071
    Location:372609
    Blast Score: 1305
    NR_LBD_Nurr1; The ligand binding domain of Nurr1, a member of conserved family of nuclear receptors
    cd06969
    Location:272346
    Blast Score: 468
    NR_DBD_NGFI-B; DNA-binding domain of the orphan nuclear receptor, nerve growth factor-induced-B

RNA

  1. XR_427087.1 RNA Sequence

Alternate HuRef

Genomic

  1. AC_000134.1 

    Range
    149066205..149074545
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018913.2 

    Range
    157187025..157195368
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_173171.1: Suppressed sequence

    Description
    NM_173171.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
  2. NM_173172.1: Suppressed sequence

    Description
    NM_173172.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
  3. NM_173173.1: Suppressed sequence

    Description
    NM_173173.1: This RefSeq was permanently suppressed because currently there is support for the transcript but not for the protein.

Supplemental Content

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