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SIRT3 sirtuin 3 [ Homo sapiens (human) ]

Gene ID: 23410, updated on 1-Mar-2015
Official Symbol
SIRT3provided by HGNC
Official Full Name
sirtuin 3provided by HGNC
Primary source
HGNC:HGNC:14931
See related
Ensembl:ENSG00000142082; HPRD:06836; MIM:604481; Vega:OTTHUMG00000119074
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SIR2L3
Summary
This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Two alternatively spliced transcript variants that encode different proteins have been described for this gene. [provided by RefSeq, Jul 2008]
Orthologs
See SIRT3 in MapViewer
Location:
11p15.5
Exon count:
7
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 11 NC_000011.10 (215030..236362, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (215030..236362, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene Bet1 golgi vesicular membrane trafficking protein-like Neighboring gene RIC8 guanine nucleotide exchange factor A Neighboring gene microRNA 6743 Neighboring gene proteasome (prosome, macropain) 26S subunit, non-ATPase, 13 Neighboring gene signal recognition particle 19kDa pseudogene Neighboring gene cytochrome c oxidase subunit VIIIB, pseudogene

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
A genome- and phenome-wide association study to identify genetic variants influencing platelet count and volume and their pleiotropic effects.
NHGRI GWA Catalog
A genome-wide association study identifies three loci associated with susceptibility to uterine fibroids.
NHGRI GWA Catalog
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
NOT NAD+ ADP-ribosyltransferase activity TAS
Traceable Author Statement
more info
PubMed 
NAD+ binding IEA
Inferred from Electronic Annotation
more info
 
NAD-dependent histone deacetylase activity (H3-K14 specific) IEA
Inferred from Electronic Annotation
more info
 
enzyme binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
zinc ion binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
aerobic respiration IMP
Inferred from Mutant Phenotype
more info
PubMed 
aging IEA
Inferred from Electronic Annotation
more info
 
histone H3 deacetylation IEA
Inferred from Electronic Annotation
more info
 
mitochondrion organization TAS
Traceable Author Statement
more info
 
organelle organization TAS
Traceable Author Statement
more info
 
peptidyl-lysine deacetylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
NOT protein ADP-ribosylation TAS
Traceable Author Statement
more info
PubMed 
protein deacetylation IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
membrane IEA
Inferred from Electronic Annotation
more info
 
mitochondrial matrix TAS
Traceable Author Statement
more info
 
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
NAD-dependent protein deacetylase sirtuin-3, mitochondrial
Names
NAD-dependent protein deacetylase sirtuin-3, mitochondrial
NAD-dependent deacetylase sirtuin-3, mitochondrial
SIR2-like protein 3
mitochondrial nicotinamide adenine dinucleotide-dependent deacetylase
regulatory protein SIR2 homolog 3
silent mating type information regulation 2, S.cerevisiae, homolog 3
sir2-like 3
sirtuin type 3

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001017524.2NP_001017524.1  NAD-dependent protein deacetylase sirtuin-3, mitochondrial isoform b

    See proteins identical to NP_001017524.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 5' end which causes the use of a downstream start codon, compared to variant 1. The resulting protein (isoform b) is shorter at the N-terminus compared to isoform a.
    Source sequence(s)
    AC069287, AF083108, AI091200, AL535769, BC001042, BI755839, BM973763, DR762907
    Consensus CDS
    CCDS53590.1
    UniProtKB/Swiss-Prot
    Q9NTG7
    Conserved Domains (1) summary
    cd01408
    Location:1231
    SIRT1; SIRT1: Eukaryotic group (class1) which includes human sirtuins SIRT1-3 and yeast Hst1-4; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 ...
  2. NM_012239.5NP_036371.1  NAD-dependent protein deacetylase sirtuin-3, mitochondrial isoform a

    See proteins identical to NP_036371.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and it encodes the longer protein (isoform a).
    Source sequence(s)
    AC069287, AF083108, AI091200, AL535769, BC001042, BM973763, DR762907
    Consensus CDS
    CCDS7691.1
    UniProtKB/Swiss-Prot
    Q9NTG7
    Related
    ENSP00000372191, OTTHUMP00000147616, ENST00000382743, OTTHUMT00000239288
    Conserved Domains (1) summary
    cd01408
    Location:138373
    SIRT1; SIRT1: Eukaryotic group (class1) which includes human sirtuins SIRT1-3 and yeast Hst1-4; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38 Primary Assembly

    Range
    215030..236362
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005252835.1XP_005252892.1  

    Conserved Domains (1) summary
    cd01408
    Location:138373
    SIRT1; SIRT1: Eukaryotic group (class1) which includes human sirtuins SIRT1-3 and yeast Hst1-4; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 ...

Alternate CHM1_1.1

Genomic

  1. NC_018922.2 Alternate CHM1_1.1

    Range
    213704..234799
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

  1. AC_000143.1 Alternate HuRef

    Range
    35047..56030
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)