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CYP4X1 cytochrome P450, family 4, subfamily X, polypeptide 1 [ Homo sapiens (human) ]

Gene ID: 260293, updated on 13-Sep-2014
Official Symbol
CYP4X1provided by HGNC
Official Full Name
cytochrome P450, family 4, subfamily X, polypeptide 1provided by HGNC
Primary source
HGNC:HGNC:20244
Locus tag
RP11-184J23.1
See related
Ensembl:ENSG00000186377; HPRD:13110; MIM:614999; Vega:OTTHUMG00000008017
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CYPIVX1
Summary
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The expression pattern of a similar rat protein suggests that this protein may be involved in neurovascular function in the brain. [provided by RefSeq, Jul 2008]
See CYP4X1 in Epigenomics, MapViewer
Location:
1p33; 1
Exon count:
12
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 1 NC_000001.11 (47023568..47050751)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (47427036..47516423)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene cytochrome P450, family 4, subfamily A, polypeptide 11 Neighboring gene cytochrome P450, family 4, subfamily A, polypeptide 11 pseudogene Neighboring gene tubulin, alpha 1c pseudogene Neighboring gene cytochrome P450, family 4, subfamily Z, polypeptide 1 Neighboring gene cytochrome P450, family 4, subfamily A, polypeptide 22

  • Serotonergic synapse, organism-specific biosystem (from KEGG)
    Serotonergic synapse, organism-specific biosystemSerotonin (5-Hydroxytryptamine, 5-HT) is a monoamine neurotransmitter that plays important roles in physiological functions such as learning and memory, emotion, sleep, pain, motor function and endoc...
  • acetone degradation I (to methylglyoxal), organism-specific biosystem (from BIOCYC)
    acetone degradation I (to methylglyoxal), organism-specific biosystemGeneral Background There are two main sources for acetone production in organisms: the decarboxylation of :3-KETOBUTYRATE (EC 4.1.1.4) and the dehydrogenation of : ISO-PROPANOL (EC 1.1.1.80). Acetoa...
  • bupropion degradation, organism-specific biosystem (from BIOCYC)
    bupropion degradation, organism-specific biosystemBupropion is a drug in the amino ketone class that was developed for use as an antidepressant . It is marketed as bupropion hydrochloride under the brand name Wellbutrin (GlaxoSmithKline). Its ex...
  • cytochrome P450, organism-specific biosystem (from WikiPathways)
    cytochrome P450, organism-specific biosystemOxidation of a substrate by Cytochrome P450. Adapted from Niesink et al., Chapter 3, p. 47-48.
  • melatonin degradation I, organism-specific biosystem (from BIOCYC)
    melatonin degradation I, organism-specific biosystemGeneral Background The indoleamine : N-ACETYL-5-METHOXY-TRYPTAMINE is a vertebrate hormone secreted by the pineal gland. It is involved in regulation of circadian and seasonal rhythms. : N-ACETYL-...
  • metapathway biotransformation, organism-specific biosystem (from WikiPathways)
    metapathway biotransformation, organism-specific biosystem
    metapathway biotransformation
  • nicotine degradation III, organism-specific biosystem (from BIOCYC)
    nicotine degradation III, organism-specific biosystemNicotine is the principal alkaloid in the leaves of commercially used tobacco (Nicotiana tabacum and N. rustica) . Nicotine in tobacco leaves and in plant-derived preparations is mostly in the (S)...
  • nicotine degradation IV, organism-specific biosystem (from BIOCYC)
    nicotine degradation IV, organism-specific biosystemNicotine is the principal alkaloid in the leaves of commercially used tobacco (Nicotiana tabacum and N. rustica) . Nicotine in tobacco leaves and in plant-derived preparations is mostly in the (S)...
  • superpathway of melatonin degradation, organism-specific biosystem (from BIOCYC)
    superpathway of melatonin degradation, organism-specific biosystem
    superpathway of melatonin degradation
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC40051

Gene Ontology Provided by GOA

Function Evidence Code Pubs
aromatase activity IEA
Inferred from Electronic Annotation
more info
 
heme binding IEA
Inferred from Electronic Annotation
more info
 
iron ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
oxidation-reduction process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
cytochrome P450 4X1
Names
cytochrome P450 4X1
NP_828847.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_007966.1 

    Range
    5001..32184
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_178033.1NP_828847.1  cytochrome P450 4X1

    See proteins identical to NP_828847.1

    Status: REVIEWED

    Source sequence(s)
    BC028102
    Consensus CDS
    CCDS544.1
    UniProtKB/Swiss-Prot
    Q8N118
    Related
    ENSP00000360968, OTTHUMP00000009712, ENST00000371901, OTTHUMT00000022017
    Conserved Domains (1) summary
    pfam00067
    Location:47501
    p450; Cytochrome P450

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000001.11 

    Range
    47023568..47050751
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

  1. AC_000133.1 

    Range
    45605361..45632362
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018912.2 

    Range
    47606010..47633192
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)