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    WNK4 WNK lysine deficient protein kinase 4 [ Homo sapiens (human) ]

    Gene ID: 65266, updated on 13-Jan-2016
    Official Symbol
    WNK4provided by HGNC
    Official Full Name
    WNK lysine deficient protein kinase 4provided by HGNC
    Primary source
    HGNC:HGNC:14544
    See related
    Ensembl:ENSG00000126562; HPRD:03505; MIM:601844; Vega:OTTHUMG00000180650
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PHA2B; PRKWNK4
    Summary
    This gene encodes a member of the WNK family of serine-threonine protein kinases. The kinase is part of the tight junction complex in kidney cells, and regulates the balance between NaCl reabsorption and K(+) secretion. The kinase regulates the activities of several types of ion channels, cotransporters, and exchangers involved in electrolyte flux in epithelial cells. Mutations in this gene result in pseudohypoaldosteronism type IIB.[provided by RefSeq, Sep 2009]
    Orthologs
    See WNK4 in Epigenomics, MapViewer
    Location:
    17q21.2
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    107 current GRCh38.p2 (GCF_000001405.28) 17 NC_000017.11 (42779673..42797066)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (40932632..40949084)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene RAMP2 antisense RNA 1 Neighboring gene receptor (G protein-coupled) activity modifying protein 2 Neighboring gene vacuolar protein sorting 25 homolog (S. cerevisiae) Neighboring gene cytochrome c oxidase assembly factor 3 Neighboring gene cyclin N-terminal domain containing 1 Neighboring gene beclin 1, autophagy related Neighboring gene microRNA 6781

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    chloride channel inhibitor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein serine/threonine kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    chloride transport IEA
    Inferred from Electronic Annotation
    more info
     
    distal tubule morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    intracellular signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    ion homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    ion transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of pancreatic juice secretion IEA
    Inferred from Electronic Annotation
    more info
     
    protein localization IEA
    Inferred from Electronic Annotation
    more info
     
    protein phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of cellular process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    renal sodium ion absorption IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    bicellular tight junction ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    serine/threonine-protein kinase WNK4
    Names
    protein kinase lysine-deficient 4
    protein kinase with no lysine 4
    NP_115763.2

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_016227.1 RefSeqGene

      Range
      5001..21436
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_032387.4NP_115763.2  serine/threonine-protein kinase WNK4

      See identical proteins and their annotated locations for NP_115763.2

      Status: REVIEWED

      Source sequence(s)
      BC136664, BM683764, CA388932
      Consensus CDS
      CCDS11439.1
      UniProtKB/Swiss-Prot
      Q96J92
      Related
      ENSP00000246914, OTTHUMP00000264871, ENST00000246914, OTTHUMT00000452389
      Conserved Domains (3) summary
      smart00220
      Location:179432
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      pfam12202
      Location:453489
      OSR1_C; Oxidative-stress-responsive kinase 1 C terminal
      cd14033
      Location:172432
      STKc_WNK4; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 4

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p2 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p2 Primary Assembly

      Range
      42779673..42797066
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005257595.3XP_005257652.1  

      Conserved Domains (3) summary
      smart00220
      Location:179432
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      pfam12202
      Location:453489
      OSR1_C; Oxidative-stress-responsive kinase 1 C terminal
      cd14033
      Location:172432
      STKc_WNK4; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 4
    2. XM_011525133.1XP_011523435.1  

      Conserved Domains (3) summary
      smart00220
      Location:179432
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      pfam12202
      Location:453489
      OSR1_C; Oxidative-stress-responsive kinase 1 C terminal
      cd14033
      Location:172432
      STKc_WNK4; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 4
    3. XM_005257597.3XP_005257654.1  

      Conserved Domains (3) summary
      smart00220
      Location:179432
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      pfam12202
      Location:453489
      OSR1_C; Oxidative-stress-responsive kinase 1 C terminal
      cd14033
      Location:172432
      STKc_WNK4; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 4
    4. XM_011525132.1XP_011523434.1  

      Conserved Domains (3) summary
      smart00220
      Location:179432
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      pfam12202
      Location:453489
      OSR1_C; Oxidative-stress-responsive kinase 1 C terminal
      cd14033
      Location:172432
      STKc_WNK4; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 4
    5. XM_005257596.2XP_005257653.1  

      Conserved Domains (3) summary
      smart00220
      Location:179432
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      pfam12202
      Location:453489
      OSR1_C; Oxidative-stress-responsive kinase 1 C terminal
      cd14033
      Location:172432
      STKc_WNK4; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 4
    6. XM_006722020.2XP_006722083.1  

      Conserved Domains (3) summary
      smart00220
      Location:179432
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      pfam12202
      Location:453489
      OSR1_C; Oxidative-stress-responsive kinase 1 C terminal
      cd14033
      Location:172432
      STKc_WNK4; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 4
    7. XM_011525134.1XP_011523436.1  

      Conserved Domains (3) summary
      smart00220
      Location:179432
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      pfam12202
      Location:453489
      OSR1_C; Oxidative-stress-responsive kinase 1 C terminal
      cd14033
      Location:172432
      STKc_WNK4; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 4
    8. XM_011525135.1XP_011523437.1  

      Conserved Domains (3) summary
      smart00220
      Location:179432
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      pfam12202
      Location:453489
      OSR1_C; Oxidative-stress-responsive kinase 1 C terminal
      cd14033
      Location:172432
      STKc_WNK4; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 4
    9. XM_006722021.1XP_006722084.1  

      Conserved Domains (2) summary
      PTZ00249
      Location:647772
      PTZ00249; variable surface protein Vir28; Provisional
      pfam12202
      Location:117153
      OSR1_C; Oxidative-stress-responsive kinase 1 C terminal
    10. XM_006722022.1XP_006722085.1  

      Conserved Domains (2) summary
      PTZ00249
      Location:647772
      PTZ00249; variable surface protein Vir28; Provisional
      pfam12202
      Location:117153
      OSR1_C; Oxidative-stress-responsive kinase 1 C terminal

    Alternate CHM1_1.1

    Genomic

    1. NC_018928.2 Alternate CHM1_1.1

      Range
      41168235..41184670
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)