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    CD274 CD274 molecule [ Homo sapiens (human) ]

    Gene ID: 29126, updated on 25-Jul-2016
    Official Symbol
    CD274provided by HGNC
    Official Full Name
    CD274 moleculeprovided by HGNC
    Primary source
    HGNC:HGNC:17635
    See related
    Ensembl:ENSG00000120217 HPRD:05655; MIM:605402; Vega:OTTHUMG00000019503
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    B7-H; B7H1; PDL1; PD-L1; PDCD1L1; PDCD1LG1
    Summary
    This gene encodes an immune inhibitory receptor ligand that is expressed by hematopoietic and non-hematopoietic cells, such as T cells and B cells and various types of tumor cells. The encoded protein is a type I transmembrane protein that has immunoglobulin V-like and C-like domains. Interaction of this ligand with its receptor inhibits T-cell activation and cytokine production. During infection or inflammation of normal tissue, this interaction is important for preventing autoimmunity by maintaining homeostasis of the immune response. In tumor microenvironments, this interaction provides an immune escape for tumor cells through cytotoxic T-cell inactivation. Expression of this gene in tumor cells is considered to be prognostic in many types of human malignancies, including colon cancer and renal cell carcinoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]
    Orthologs
    Location:
    9p24
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 9 NC_000009.12 (5450503..5470567)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (5450503..5470567)

    Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene plasminogen receptor with a C-terminal lysine Neighboring gene collagen alpha-1(III) chain-like Neighboring gene ring finger protein 152 pseudogene 1 Neighboring gene uncharacterized LOC107987045 Neighboring gene programmed cell death 1 ligand 2 Neighboring gene uncharacterized LOC105375967

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env The low mannose-level gp120 induces higher activation of plasmacytoid dendritic cells by upregulation of IFN-alpha, PD-L1, CD40, CCR7, CD80, and CD86 than the high mannose-level gp120 does PubMed
    Tat tat HIV-1 Tat-induced upregulation of PD-L1 on monocyte-derived dendritic cells involves a TNF-alpha-mediated mechanism through the TLR4 pathway PubMed
    tat The N-terminal domain (residues 1-45) of HIV-1 Tat is required for the Tat-induced upregulation of PD-L1 in monocyte-derived dendritic cells PubMed
    tat HIV-1 Tat upregulates the expression of PD-L1 on the surface of dendritic cells and monocyte-derived dendritic cells PubMed
    tat HIV-1 Tat-induced upregulation of B7-H1 protein expression requires activation of the ERK/MAPK signaling pathway in human endothelial cells PubMed

    Go to the HIV-1, Human Interaction Database

    • Adaptive Immune System, organism-specific biosystem (from REACTOME)
      Adaptive Immune System, organism-specific biosystemAdaptive immunity refers to antigen-specific immune response efficiently involved in clearing the pathogens. The adaptive immune system is comprised of B and T lymphocytes that express receptors with...
    • Cell adhesion molecules (CAMs), organism-specific biosystem (from KEGG)
      Cell adhesion molecules (CAMs), organism-specific biosystemCell adhesion molecules are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, em...
    • Cell adhesion molecules (CAMs), conserved biosystem (from KEGG)
      Cell adhesion molecules (CAMs), conserved biosystemCell adhesion molecules are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, em...
    • Costimulation by the CD28 family, organism-specific biosystem (from REACTOME)
      Costimulation by the CD28 family, organism-specific biosystemOptimal activation of T-lymphocytes requires at least two signals. A primary one is delivered by the T-cell receptor (TCR) complex after antigen recognition and additional costimulatory signals are d...
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    • PD-1 signaling, organism-specific biosystem (from REACTOME)
      PD-1 signaling, organism-specific biosystemThe Programmed cell death protein 1 (PD-1) is one of the negative regulators of TCR signaling. PD-1 may exert its effects on cell differentiation and survival directly by inhibiting early activation ...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • MGC142294, MGC142296

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    endomembrane system IEA
    Inferred from Electronic Annotation
    more info
     
    external side of plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular exosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane TAS
    Traceable Author Statement
    more info
     
    Preferred Names
    programmed cell death 1 ligand 1
    Names
    B7 homolog 1
    CD274 antigen
    PDCD1 ligand 1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001267706.1NP_001254635.1  programmed cell death 1 ligand 1 isoform b precursor

      See identical proteins and their annotated locations for NP_001254635.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. This results in a shorter protein (isoform b), compared to isoform a.
      Source sequence(s)
      AI826502, AL135786, AL162253, AY291313, DQ836393
      Consensus CDS
      CCDS59118.1
      UniProtKB/Swiss-Prot
      Q9NZQ7
      UniProtKB/TrEMBL
      Q0GN75
      Related
      ENSP00000370985, ENST00000381573
      Conserved Domains (1) summary
      cd00098
      Location:3996
      IgC; Immunoglobulin Constant domain
    2. NM_001314029.1NP_001300958.1  programmed cell death 1 ligand 1 isoform c precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks several exons and its 3' terminal exon extends past a splice site that is used in variant 1. This results in a novel 3' coding region and novel 3' UTR compared to variant 1. It encodes isoform c which is shorter than and has a distinct C-terminus compared to isoform a.
      Source sequence(s)
      AA399416, AL135786, DB160805, DQ836393
      UniProtKB/TrEMBL
      Q0GN75
      Conserved Domains (3) summary
      cd00098
      Location:153210
      IgC; Immunoglobulin Constant domain
      smart00410
      Location:24130
      IG_like; Immunoglobulin like
      cl11960
      Location:66114
      Ig; Immunoglobulin domain
    3. NM_014143.3NP_054862.1  programmed cell death 1 ligand 1 isoform a precursor

      See identical proteins and their annotated locations for NP_054862.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
      Source sequence(s)
      AI826502, AK314567, AL135786, AL162253
      Consensus CDS
      CCDS6464.1
      UniProtKB/Swiss-Prot
      Q9NZQ7
      Related
      ENSP00000370989, OTTHUMP00000021029, ENST00000381577, OTTHUMT00000051631
      Conserved Domains (3) summary
      cd00098
      Location:153210
      IgC; Immunoglobulin Constant domain
      smart00410
      Location:24130
      IG_like; Immunoglobulin like
      cl11960
      Location:66114
      Ig; Immunoglobulin domain

    RNA

    1. NR_052005.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an alternate internal segment, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AI826502, AL135786, AL162253, AY714881, DQ836393

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000009.12 Reference GRCh38.p7 Primary Assembly

      Range
      5450503..5470567
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.1

    Genomic

    1. NC_018920.2 Alternate CHM1_1.1

      Range
      5450664..5470759
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)