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SIN3A SIN3 transcription regulator family member A [ Homo sapiens (human) ]

Gene ID: 25942, updated on 11-Sep-2014
Official Symbol
SIN3Aprovided by HGNC
Official Full Name
SIN3 transcription regulator family member Aprovided by HGNC
Primary source
HGNC:HGNC:19353
See related
Ensembl:ENSG00000169375; HPRD:09690; MIM:607776; Vega:OTTHUMG00000142834
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
The protein encoded by this gene is a transcriptional regulatory protein. It contains paired amphipathic helix (PAH) domains, which are important for protein-protein interactions and may mediate repression by the Mad-Max complex. [provided by RefSeq, Jul 2008]
See SIN3A in Epigenomics, MapViewer
Location:
15q24.2
Exon count:
26
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 15 NC_000015.10 (75369379..75455815, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (75661720..75748181, complement)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene nei endonuclease VIII-like 1 (E. coli) Neighboring gene microRNA 631 Neighboring gene mannosidase, alpha, class 2C, member 1 Neighboring gene ribosomal protein L13 pseudogene 4 Neighboring gene uncharacterized LOC102723785 Neighboring gene protein tyrosine phosphatase, non-receptor type 9 Neighboring gene snurportin 1

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
A genome-wide association study in 19 633 Japanese subjects identified LHX3-QSOX2 and IGF1 as adult height loci.
NHGRI GWA Catalog
GWAS for discovery and replication of genetic loci associated with sudden cardiac arrest in patients with coronary artery disease.
NHGRI GWA Catalog

Protein interactions

Protein Gene Interaction Pubs
Tat tat The SIN3/HDAC complex, composed of SIN3A, SAP30, SAP18, HDAC-1 AND -2 and RbAp46/48 except SAP30, are identified to interact with HIV-1 Tat in Jurkat cell PubMed
integrase gag-pol HIV-1 IN and INI1/hSNF5 bind SAP18 and selectively recruit components of Sin3a-HDAC1 complex into HIV-1 virions. HIV-1 virion-associated HDAC1 is required for efficient early post-entry events PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ90319, KIAA0700, DKFZp434K2235

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA polymerase II activating transcription factor binding IPI
Inferred from Physical Interaction
more info
 
RNA polymerase II repressing transcription factor binding IEA
Inferred from Electronic Annotation
more info
 
RNA polymerase II transcription corepressor activity IEA
Inferred from Electronic Annotation
more info
 
chromatin binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein complex binding IEA
Inferred from Electronic Annotation
more info
 
protein deacetylase activity IMP
Inferred from Mutant Phenotype
more info
 
sequence-specific DNA binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
 
transcription regulatory region sequence-specific DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
DNA replication IEA
Inferred from Electronic Annotation
more info
 
activation of innate immune response IMP
Inferred from Mutant Phenotype
more info
 
aging IEA
Inferred from Electronic Annotation
more info
 
blood coagulation TAS
Traceable Author Statement
more info
 
cellular lipid metabolic process TAS
Traceable Author Statement
more info
 
cellular protein localization IEA
Inferred from Electronic Annotation
more info
 
cellular response to glucose stimulus IEA
Inferred from Electronic Annotation
more info
 
hematopoietic progenitor cell differentiation IEA
Inferred from Electronic Annotation
more info
 
in utero embryonic development IEA
Inferred from Electronic Annotation
more info
 
negative regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of circadian rhythm ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of histone H3-K27 acetylation IMP
Inferred from Mutant Phenotype
more info
 
negative regulation of protein localization to nucleus IMP
Inferred from Mutant Phenotype
more info
 
negative regulation of transcription from RNA polymerase II promoter IMP
Inferred from Mutant Phenotype
more info
 
negative regulation of transcription regulatory region DNA binding IMP
Inferred from Mutant Phenotype
more info
 
negative regulation of transcription, DNA-templated ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of G2/M transition of mitotic cell cycle IEA
Inferred from Electronic Annotation
more info
 
positive regulation of chromatin silencing IMP
Inferred from Mutant Phenotype
more info
 
positive regulation of defense response to virus by host IMP
Inferred from Mutant Phenotype
more info
 
positive regulation of transcription from RNA polymerase II promoter IMP
Inferred from Mutant Phenotype
more info
 
protein deacetylation IMP
Inferred from Mutant Phenotype
more info
 
regulation of transcription from RNA polymerase II promoter in response to oxidative stress IEA
Inferred from Electronic Annotation
more info
 
response to methylglyoxal IEA
Inferred from Electronic Annotation
more info
 
response to organonitrogen compound IEA
Inferred from Electronic Annotation
more info
 
rhythmic process IEA
Inferred from Electronic Annotation
more info
 
small molecule metabolic process TAS
Traceable Author Statement
more info
 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Sin3 complex IDA
Inferred from Direct Assay
more info
PubMed 
Sin3 complex NAS
Non-traceable Author Statement
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
 
intercellular bridge IDA
Inferred from Direct Assay
more info
 
kinetochore IEA
Inferred from Electronic Annotation
more info
 
NOT nucleolus IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
 
nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 
transcription factor complex IEA
Inferred from Electronic Annotation
more info
 
transcriptional repressor complex IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
paired amphipathic helix protein Sin3a
Names
paired amphipathic helix protein Sin3a
transcriptional regulator, SIN3A
transcriptional corepressor Sin3a
transcriptional co-repressor Sin3A
SIN3 transcription regulator homolog A
SIN3 homolog A, transcription regulator
histone deacetylase complex subunit Sin3a

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001145357.1NP_001138829.1  paired amphipathic helix protein Sin3a

    See proteins identical to NP_001138829.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AC068338, AF418569, AL832463, BM676304
    Consensus CDS
    CCDS10279.1
    UniProtKB/Swiss-Prot
    Q96ST3
    Conserved Domains (3) summary
    COG5602
    Location:51213
    SIN3; Histone deacetylase complex, SIN3 component [Chromatin structure and dynamics]
    pfam02671
    Location:141187
    PAH; Paired amphipathic helix repeat
    pfam08295
    Location:550650
    Sin3_corepress; Sin3 family co-repressor
  2. NM_001145358.1NP_001138830.1  paired amphipathic helix protein Sin3a

    See proteins identical to NP_001138830.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AC068338, AF418569, AK096477, BM676304, DB074084
    Consensus CDS
    CCDS10279.1
    UniProtKB/Swiss-Prot
    Q96ST3
    Related
    ENSP00000378402, OTTHUMP00000183517, ENST00000394947, OTTHUMT00000286469
    Conserved Domains (3) summary
    COG5602
    Location:51213
    SIN3; Histone deacetylase complex, SIN3 component [Chromatin structure and dynamics]
    pfam02671
    Location:141187
    PAH; Paired amphipathic helix repeat
    pfam08295
    Location:550650
    Sin3_corepress; Sin3 family co-repressor
  3. NM_015477.2NP_056292.1  paired amphipathic helix protein Sin3a

    See proteins identical to NP_056292.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AC068338, AF418569, BC041047, BM676304
    Consensus CDS
    CCDS10279.1
    UniProtKB/Swiss-Prot
    Q96ST3
    Conserved Domains (3) summary
    COG5602
    Location:51213
    SIN3; Histone deacetylase complex, SIN3 component [Chromatin structure and dynamics]
    pfam02671
    Location:141187
    PAH; Paired amphipathic helix repeat
    pfam08295
    Location:550650
    Sin3_corepress; Sin3 family co-repressor

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000015.10 

    Range
    75369379..75455815
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006720465.1XP_006720528.1  

    See proteins identical to XP_006720528.1

    UniProtKB/Swiss-Prot
    Q96ST3
    Related
    ENSP00000353622, OTTHUMP00000183518, ENST00000360439, OTTHUMT00000286470
    Conserved Domains (3) summary
    COG5602
    Location:51213
    SIN3; Histone deacetylase complex, SIN3 component [Chromatin structure and dynamics]
    pfam02671
    Location:141187
    PAH; Paired amphipathic helix repeat
    pfam08295
    Location:550650
    Sin3_corepress; Sin3 family co-repressor
  2. XM_006720467.1XP_006720530.1  

    See proteins identical to XP_006720530.1

    UniProtKB/Swiss-Prot
    Q96ST3
    Conserved Domains (3) summary
    COG5602
    Location:51213
    SIN3; Histone deacetylase complex, SIN3 component [Chromatin structure and dynamics]
    pfam02671
    Location:141187
    PAH; Paired amphipathic helix repeat
    pfam08295
    Location:550650
    Sin3_corepress; Sin3 family co-repressor
  3. XM_006720466.1XP_006720529.1  

    See proteins identical to XP_006720529.1

    UniProtKB/Swiss-Prot
    Q96ST3
    Conserved Domains (3) summary
    COG5602
    Location:51213
    SIN3; Histone deacetylase complex, SIN3 component [Chromatin structure and dynamics]
    pfam02671
    Location:141187
    PAH; Paired amphipathic helix repeat
    pfam08295
    Location:550650
    Sin3_corepress; Sin3 family co-repressor

Alternate HuRef

Genomic

  1. AC_000147.1 

    Range
    52420097..52506377
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018926.2 

    Range
    75780322..75866699
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)