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    MTSS1 MTSS1, I-BAR domain containing [ Homo sapiens (human) ]

    Gene ID: 9788, updated on 14-Aug-2016
    Official Symbol
    MTSS1provided by HGNC
    Official Full Name
    MTSS1, I-BAR domain containingprovided by HGNC
    Primary source
    HGNC:HGNC:20443
    See related
    Ensembl:ENSG00000170873 HPRD:12243; MIM:608486; Vega:OTTHUMG00000048189
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MIM; MIMA; MIMB
    Orthologs
    Location:
    8p22
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 8 NC_000008.11 (124550770..124728507, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (125563025..125740730, complement)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene TatD DNase domain containing 1 Neighboring gene microRNA 6844 Neighboring gene NADH:ubiquinone oxidoreductase subunit B9 Neighboring gene uncharacterized LOC105375740 Neighboring gene uncharacterized LOC105375741 Neighboring gene microRNA 4662b Neighboring gene microRNA 4662a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    NHGRI GWAS Catalog

    Description
    Heritability and genetic association analysis of cognition in the Diabetes Heart Study.
    NHGRI GWA Catalog
    Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.
    NHGRI GWA Catalog
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • FLJ44694, KIAA0429, DKFZp781P2223

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    actin monomer binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    actin cytoskeleton organization TAS
    Traceable Author Statement
    more info
    PubMed 
    cell adhesion NAS
    Non-traceable Author Statement
    more info
    PubMed 
    cellular response to fluid shear stress ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    epithelial cell proliferation involved in renal tubule morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    glomerulus morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    microspike assembly NAS
    Non-traceable Author Statement
    more info
    PubMed 
    movement of cell or subcellular component NAS
    Non-traceable Author Statement
    more info
    PubMed 
    negative regulation of epithelial cell proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    nephron tubule epithelial cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    plasma membrane organization IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of defense response to virus by host IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    renal tubule morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    transmembrane receptor protein tyrosine kinase signaling pathway TAS
    Traceable Author Statement
    more info
    PubMed 
    xenophagy IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    actin cytoskeleton IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm TAS
    Traceable Author Statement
    more info
    PubMed 
    endocytic vesicle TAS
    Traceable Author Statement
    more info
    PubMed 
    ruffle NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Preferred Names
    metastasis suppressor protein 1
    Names
    metastasis suppressor 1
    metastasis suppressor YGL-1
    missing in metastasis protein

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001282971.1NP_001269900.1  metastasis suppressor protein 1 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC090198, AJ710067, AK027015, DA790325
      Consensus CDS
      CCDS64969.1
      UniProtKB/Swiss-Prot
      O43312
      Related
      ENSP00000322804, OTTHUMP00000228306, ENST00000325064, OTTHUMT00000381615
      Conserved Domains (2) summary
      cd07643
      Location:7241
      I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis
      pfam02205
      Location:728754
      WH2; WH2 motif
    2. NM_001282974.1NP_001269903.1  metastasis suppressor protein 1 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) has multiple differences in the coding region but maintains the reading frame, compared to variant 1. This variant encodes isoform 3, which is shorter than isoform 1.
      Source sequence(s)
      AC090198, AF086645, AJ710067, DA790325, EF560715
      Consensus CDS
      CCDS64968.1
      UniProtKB/Swiss-Prot
      O43312
      UniProtKB/TrEMBL
      A5YM41
      Related
      ENSP00000367256, OTTHUMP00000228225, ENST00000378017, OTTHUMT00000109623
      Conserved Domains (2) summary
      cd07643
      Location:7237
      I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis
      pfam02205
      Location:699725
      WH2; WH2 motif
    3. NM_014751.5NP_055566.3  metastasis suppressor protein 1 isoform 2

      See identical proteins and their annotated locations for NP_055566.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an in-frame exon in the central coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AC090198, AF086645, AJ710067, DA790325
      Consensus CDS
      CCDS6353.1
      UniProtKB/Swiss-Prot
      O43312
      Related
      ENSP00000429064, OTTHUMP00000045859, ENST00000518547, OTTHUMT00000109625
      Conserved Domains (2) summary
      cd07643
      Location:7237
      I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis
      pfam02205
      Location:724750
      WH2; WH2 motif

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p7 Primary Assembly

      Range
      124550770..124728507 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017014099.1XP_016869588.1  

    2. XM_017014093.1XP_016869582.1  

    3. XM_017014086.1XP_016869575.1  

    4. XM_017014097.1XP_016869586.1  

    5. XM_017014089.1XP_016869578.1  

    6. XM_017014100.1XP_016869589.1  

    7. XM_017014098.1XP_016869587.1  

    8. XM_017014092.1XP_016869581.1  

    9. XM_017014094.1XP_016869583.1  

    10. XM_006716701.1XP_006716764.1  

      Conserved Domains (2) summary
      cd07643
      Location:7237
      I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis
      pfam02205
      Location:833859
      WH2; WH2 motif
    11. XM_017014088.1XP_016869577.1  

    12. XM_006716704.1XP_006716767.1  

      Conserved Domains (2) summary
      cd07643
      Location:7241
      I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis
      pfam02205
      Location:727753
      WH2; WH2 motif
    13. XM_006716700.1XP_006716763.1  

      Conserved Domains (2) summary
      cd07643
      Location:7241
      I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis
      pfam02205
      Location:836862
      WH2; WH2 motif
    14. XM_017014096.1XP_016869585.1  

    15. XM_006716706.1XP_006716769.1  

      Conserved Domains (2) summary
      cd07643
      Location:7241
      I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis
      pfam02205
      Location:646672
      WH2; WH2 motif
    16. XM_006716703.1XP_006716766.1  

      Conserved Domains (2) summary
      cd07643
      Location:7241
      I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis
      pfam02205
      Location:755781
      WH2; WH2 motif
    17. XM_005251118.1XP_005251175.1  

      Conserved Domains (2) summary
      cd07643
      Location:7241
      I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis
      pfam02205
      Location:663689
      WH2; WH2 motif
    18. XM_005251113.1XP_005251170.1  

      Conserved Domains (2) summary
      cd07643
      Location:7241
      I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis
      pfam02205
      Location:772798
      WH2; WH2 motif
    19. XM_006716705.1XP_006716768.1  

      Conserved Domains (2) summary
      cd07643
      Location:7241
      I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis
      pfam02205
      Location:711737
      WH2; WH2 motif
    20. XM_006716702.1XP_006716765.1  

      Conserved Domains (2) summary
      cd07643
      Location:7241
      I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis
      pfam02205
      Location:820846
      WH2; WH2 motif
    21. XM_005251111.1XP_005251168.1  

      Conserved Domains (2) summary
      cd07643
      Location:7241
      I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis
      pfam02205
      Location:837863
      WH2; WH2 motif
    22. XM_017014095.1XP_016869584.1  

    23. XM_017014087.1XP_016869576.1  

    24. XM_011517403.1XP_011515705.1  

      Conserved Domains (2) summary
      pfam02205
      Location:770796
      WH2; WH2 motif
      cl12013
      Location:1174
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    25. XM_017014091.1XP_016869580.1  

    26. XM_011517404.2XP_011515706.1  

      Conserved Domains (2) summary
      pfam02205
      Location:756782
      WH2; WH2 motif
      cl12013
      Location:1160
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    27. XM_017014090.1XP_016869579.1  

    28. XM_011517407.1XP_011515709.1  

      Conserved Domains (1) summary
      pfam02205
      Location:479505
      WH2; WH2 motif
    29. XM_017014101.1XP_016869590.1  

    Alternate CHM1_1.1

    Genomic

    1. NC_018919.2 Alternate CHM1_1.1

      Range
      125603254..125781001 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)