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    PROK2 prokineticin 2 [ Homo sapiens (human) ]

    Gene ID: 60675, updated on 11-Sep-2016
    Official Symbol
    PROK2provided by HGNC
    Official Full Name
    prokineticin 2provided by HGNC
    Primary source
    HGNC:HGNC:18455
    See related
    Ensembl:ENSG00000163421 HPRD:08446; MIM:607002; Vega:OTTHUMG00000158809
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    BV8; HH4; PK2; KAL4; MIT1
    Summary
    This gene encodes a protein expressed in the suprachiasmatic nucleus (SCN) circadian clock that may function as the output component of the circadian clock. The secreted form of the encoded protein may also serve as a chemoattractant for neuronal precursor cells in the olfactory bulb. Proteins from other vertebrates which are similar to this gene product were isolated based on homology to snake venom and secretions from frog skin, and have been shown to have diverse functions. Mutations in this gene are associated with Kallmann syndrome 4. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
    Orthologs
    Location:
    3p13
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 3 NC_000003.12 (71771655..71785206, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (71820806..71834357, complement)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105377155 Neighboring gene eukaryotic translation initiation factor 4E family member 3 Neighboring gene G protein-coupled receptor 27 Neighboring gene uncharacterized LOC105377156 Neighboring gene RNA, 7SL, cytoplasmic 271, pseudogene

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Protein interactions

    Protein Gene Interaction Pubs
    Vif vif HIV-1 Vif upregulates the expression of prokineticin 2 (PROK2) in Vif-expression T cells PubMed

    Go to the HIV-1, Human Interaction Database

    • Class A/1 (Rhodopsin-like receptors), organism-specific biosystem (from REACTOME)
      Class A/1 (Rhodopsin-like receptors), organism-specific biosystemRhodopsin-like receptors (class A/1) are the largest group of GPCRs and are the best studied group from a functional and structural point of view. They show great diversity at the sequence level and ...
    • G alpha (q) signalling events, organism-specific biosystem (from REACTOME)
      G alpha (q) signalling events, organism-specific biosystemThe classic signalling route for G alpha (q) is activation of phospholipase C beta thereby triggering phosphoinositide hydrolysis, calcium mobilization and protein kinase C activation. This provides ...
    • GPCR downstream signaling, organism-specific biosystem (from REACTOME)
      GPCR downstream signaling, organism-specific biosystemG protein-coupled receptors (GPCRs) are classically defined as the receptor, G-protein and downstream effectors, the alpha subunit of the G-protein being the primary signaling molecule. However, it h...
    • GPCR ligand binding, organism-specific biosystem (from REACTOME)
      GPCR ligand binding, organism-specific biosystemThere are more than 800 G-protein coupled receptor (GPCRs) in the human genome, making it the largest receptor superfamily. GPCRs are also the largest class of drug targets, involved in virtually all...
    • Gastrin-CREB signalling pathway via PKC and MAPK, organism-specific biosystem (from REACTOME)
      Gastrin-CREB signalling pathway via PKC and MAPK, organism-specific biosystemGastrin is a hormone whose main function is to stimulate secretion of hydrochloric acid by the gastric mucosa, which results in gastrin formation inhibition. This hormone also acts as a mitogenic fac...
    • Peptide ligand-binding receptors, organism-specific biosystem (from REACTOME)
      Peptide ligand-binding receptors, organism-specific biosystemThese receptors, a subset of the Class A/1 (Rhodopsin-like) family, all bind peptide ligands which include the chemokines, opioids and somatostatins.
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Signaling by GPCR, organism-specific biosystem (from REACTOME)
      Signaling by GPCR, organism-specific biosystemG protein-coupled receptors (GPCRs; 7TM receptors; seven transmembrane domain receptors; heptahelical receptors; G protein-linked receptors [GPLR]) are the largest family of transmembrane receptors i...

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    G-protein coupled receptor binding TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    G-protein coupled receptor signaling pathway NAS
    Non-traceable Author Statement
    more info
    PubMed 
    activation of MAPK activity TAS
    Traceable Author Statement
    more info
    PubMed 
    angiogenesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    chemotaxis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    circadian rhythm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    inflammatory response NAS
    Non-traceable Author Statement
    more info
    PubMed 
    negative regulation of apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    neuropeptide signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of cell proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    positive regulation of cytosolic calcium ion concentration TAS
    Traceable Author Statement
    more info
    PubMed 
    positive regulation of smooth muscle contraction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of angiogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    sensory perception of pain TAS
    Traceable Author Statement
    more info
    PubMed 
    spermatogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    cell IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular region TAS
    Traceable Author Statement
    more info
    PubMed 
    Preferred Names
    prokineticin-2
    Names
    protein Bv8 homolog

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_008275.1 RefSeqGene

      Range
      5001..18552
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001126128.1NP_001119600.1  prokineticin-2 isoform a precursor

      See identical proteins and their annotated locations for NP_001119600.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (a).
      Source sequence(s)
      AC096970, BC098162
      Consensus CDS
      CCDS46868.1
      UniProtKB/Swiss-Prot
      Q9HC23
      Related
      ENSP00000295619, OTTHUMP00000213531, ENST00000295619, OTTHUMT00000352302
      Conserved Domains (1) summary
      pfam06607
      Location:23126
      Prokineticin; Prokineticin
    2. NM_021935.3NP_068754.1  prokineticin-2 isoform b precursor

      See identical proteins and their annotated locations for NP_068754.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon, compared to variant 1, resulting in a shorter protein (isoform b), compared to isoform a.
      Source sequence(s)
      AC096970, BC069395
      Consensus CDS
      CCDS2916.1
      UniProtKB/Swiss-Prot
      Q9HC23
      Related
      ENSP00000295618, OTTHUMP00000213530, ENST00000353065, OTTHUMT00000352301
      Conserved Domains (1) summary
      pfam06607
      Location:23105
      Prokineticin; Prokineticin

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p7 Primary Assembly

      Range
      71771655..71785206 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017006974.1XP_016862463.1  

    Alternate CHM1_1.1

    Genomic

    1. NC_018914.2 Alternate CHM1_1.1

      Range
      71772193..71785741 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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