Format

Send to:

Choose Destination

Links from PubMed

    • Showing Current items.

    ACP6 acid phosphatase 6, lysophosphatidic [ Homo sapiens (human) ]

    Gene ID: 51205, updated on 8-Aug-2016
    Official Symbol
    ACP6provided by HGNC
    Official Full Name
    acid phosphatase 6, lysophosphatidicprovided by HGNC
    Primary source
    HGNC:HGNC:29609
    See related
    Ensembl:ENSG00000162836 HPRD:16472; MIM:611471; Vega:OTTHUMG00000014019
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    LPAP; ACPL1; PACPL1
    Summary
    This gene encodes a member of the histidine acid phosphatase protein family. The encoded protein hydrolyzes lysophosphatidic acid, which is involved in G protein-coupled receptor signaling, lipid raft modulation, and in balancing lipid composition within the cell. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2016]
    Orthologs
    Location:
    1q21
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 1 NC_000001.11 (147629658..147670543, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (147119168..147142634, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 624 Neighboring gene olfactory receptor family 13 subfamily Z member 3 pseudogene Neighboring gene B-cell CLL/lymphoma 9 Neighboring gene uncharacterized LOC102723321 Neighboring gene uncharacterized LOC105371230 Neighboring gene RNA, 7SL, cytoplasmic 261, pseudogene

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    acid phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    lysophosphatidic acid phosphatase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    lysobisphosphatidic acid metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    phospholipid metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    lysophosphatidic acid phosphatase type 6
    Names
    acid phosphatase-like protein 1
    NP_001310554.1
    NP_057445.4

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_050757.1 RefSeqGene

      Range
      5032..28178
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001323625.1NP_001310554.1  lysophosphatidic acid phosphatase type 6 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 3' UTR and coding region, compared to variant 1. The encoded isoform (2) has a shorter and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC241644
    2. NM_016361.4NP_057445.4  lysophosphatidic acid phosphatase type 6 isoform 1

      See identical proteins and their annotated locations for NP_057445.4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AB031478, AB209248, AL520992, BC009965
      Consensus CDS
      CCDS928.1
      UniProtKB/Swiss-Prot
      Q9NPH0
      UniProtKB/TrEMBL
      X5D289
      Related
      ENSP00000463574, OTTHUMP00000276927, ENST00000583509, OTTHUMT00000039420
      Conserved Domains (1) summary
      cd07061
      Location:49379
      HP_HAP_like; Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction

    RNA

    1. NR_136633.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) uses an alternate internal exon and includes an alternate segment in the 3' end, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC241644
    2. NR_136634.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) uses an alternate splice site in the 5'-terminal exon, includes two alternate internal exons, and includes an alternate segment in the 3' end, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC241644
    3. NR_136635.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) uses an alternate internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC241644
    4. NR_136636.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) uses an alternate splice site in the 5'-terminal exon, includes an alternate internal exon, and includes an alternate segment in the 3' end, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC241644

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p7 Primary Assembly

      Range
      147629658..147670543 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011509601.2XP_011507903.1  

      Conserved Domains (1) summary
      cd07061
      Location:49379
      HP_HAP_like; Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction
    2. XM_017001422.1XP_016856911.1  

    Alternate CHM1_1.1

    Genomic

    1. NC_018912.2 Alternate CHM1_1.1

      Range
      149015492..149038669 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)