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HOXA13 homeobox A13 [ Homo sapiens (human) ]

Gene ID: 3209, updated on 27-Apr-2015
Official Symbol
HOXA13provided by HGNC
Official Full Name
homeobox A13provided by HGNC
Primary source
HGNC:HGNC:5102
See related
HPRD:00847; MIM:142959
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HOX1; HOX1J
Summary
In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. Expansion of a polyalanine tract in the encoded protein can cause hand-foot-uterus syndrome, also known as hand-foot-genital syndrome. [provided by RefSeq, Jul 2008]
Orthologs
See HOXA13 in MapViewer
Location:
7p15.2
Exon count:
3
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 7 NC_000007.14 (27193419..27200266, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (27236499..27239725, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene homeobox A11 Neighboring gene HOXA11 antisense RNA Neighboring gene HOXA distal transcript antisense RNA Neighboring gene EVX1 antisense RNA Neighboring gene even-skipped homeobox 1

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat specifically associates with HOXA13 promoter to upregulate HOXA13 expression in T cells PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding TAS
Traceable Author Statement
more info
PubMed 
sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 
sequence-specific DNA binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
 
transcription regulatory region DNA binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
artery morphogenesis IEA
Inferred from Electronic Annotation
more info
 
branching involved in prostate gland morphogenesis IEA
Inferred from Electronic Annotation
more info
 
embryonic forelimb morphogenesis IEA
Inferred from Electronic Annotation
more info
 
endothelial cell fate specification IEA
Inferred from Electronic Annotation
more info
 
endothelial cell morphogenesis IEA
Inferred from Electronic Annotation
more info
 
inner ear development IEA
Inferred from Electronic Annotation
more info
 
male genitalia development IEA
Inferred from Electronic Annotation
more info
 
positive regulation of mesenchymal cell apoptotic process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of mitotic nuclear division IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transcription from RNA polymerase II promoter IEA
Inferred from Electronic Annotation
more info
 
regulation of BMP signaling pathway IEA
Inferred from Electronic Annotation
more info
 
skeletal system development TAS
Traceable Author Statement
more info
PubMed 
tissue homeostasis IEA
Inferred from Electronic Annotation
more info
 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
vasculogenesis IEA
Inferred from Electronic Annotation
more info
 
ventricular septum development IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
intermediate filament cytoskeleton IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus IDA
Inferred from Direct Assay
more info
 
Preferred Names
homeobox protein Hox-A13
Names
homeobox protein Hox-A13
homeo box 1J
homeo box A13
homeobox protein HOXA13
homeobox protein Hox-1J
transcription factor HOXA13

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_008181.1 RefSeqGene

    Range
    5001..8227
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000522.4NP_000513.2  homeobox protein Hox-A13

    See identical proteins and their annotated locations for NP_000513.2

    Status: REVIEWED

    Source sequence(s)
    AC004080, BC016712, BC075791
    Consensus CDS
    CCDS5412.1
    UniProtKB/Swiss-Prot
    P31271
    UniProtKB/TrEMBL
    Q6DI00
    Conserved Domains (2) summary
    cd00086
    Location:323379
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    pfam12284
    Location:85224
    HoxA13_N; Hox protein A13 N terminal

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p2 Primary Assembly

    Range
    27193419..27200266
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011515344.1XP_011513646.1  

    See identical proteins and their annotated locations for XP_011513646.1

    Conserved Domains (2) summary
    cd00086
    Location:323379
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    pfam12284
    Location:85224
    HoxA13_N; Hox protein A13 N terminal

Alternate CHM1_1.1

Genomic

  1. NC_018918.2 Alternate CHM1_1.1

    Range
    27236223..27239448
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)