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PRKCZ protein kinase C, zeta [ Homo sapiens (human) ]

Gene ID: 5590, updated on 7-Jul-2014
Official Symbol
PRKCZprovided by HGNC
Official Full Name
protein kinase C, zetaprovided by HGNC
Primary source
HGNC:9412
Locus tag
RP11-181G12.1
See related
Ensembl:ENSG00000067606; HPRD:01504; MIM:176982; Vega:OTTHUMG00000001238
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PKC2; PKC-ZETA
Summary
Protein kinase C (PKC) zeta is a member of the PKC family of serine/threonine kinases which are involved in a variety of cellular processes such as proliferation, differentiation and secretion. Unlike the classical PKC isoenzymes which are calcium-dependent, PKC zeta exhibits a kinase activity which is independent of calcium and diacylglycerol but not of phosphatidylserine. Furthermore, it is insensitive to typical PKC inhibitors and cannot be activated by phorbol ester. Unlike the classical PKC isoenzymes, it has only a single zinc finger module. These structural and biochemical properties indicate that the zeta subspecies is related to, but distinct from other isoenzymes of PKC. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
See PRKCZ in Epigenomics, MapViewer
Location:
1p36.33-p36.2
Exon count :
25
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 1 NC_000001.11 (2050470..2185395)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (1981909..2116834)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene KIAA1751 Neighboring gene gamma-aminobutyric acid (GABA) A receptor, delta Neighboring gene uncharacterized LOC101929017 Neighboring gene uncharacterized LOC100506504 Neighboring gene chromosome 1 open reading frame 86 Neighboring gene SKI proto-oncogene Neighboring gene small nuclear ribonucleoprotein polypeptide N pseudogene Neighboring gene MORN repeat containing 1

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Genome-wide pharmacogenomic study of neurocognition as an indicator of antipsychotic treatment response in schizophrenia.
NHGRI GWA Catalog
Hundreds of variants clustered in genomic loci and biological pathways affect human height.
NHGRI GWA Catalog

Protein interactions

Protein Gene Interaction Pubs
Env, gp160, envelope glycoprotein env HIV-1 gp160-induced AP-1 complex formation is dependent upon protein tyrosine phosphorylation and is abolished by inhibitors of protein kinase C, but it is unaffected by calcium channel blockers or cyclosporine A PubMed
Envelope surface glycoprotein gp120 env HIV-1 gp120 activates forward trafficking and surface clustering of NMDA receptors in membrane microdomains by a PKA-dependent phosphorylation of the NR1 C-terminal Ser897, followed by a PKC-dependent phosphorylation of Ser896 PubMed
env Down modulation of the interaction between HIV-1 gp120 and CD4 by TPA is blocked by protein kinase C (PKC) inhibitors, suggesting PKC may play an important role in HIV-1 infection PubMed
env c-FLIPL inhibits Bax activation via modulating PKC expression at the transcriptional level involving AP-2 during gp120 treatment PubMed
env Induction of apoptosis in cell cultures through binding of HIV-1 gp120 or gp160 to CXCR4 involves protein kinase C, basic fibroblast growth factor, caspase-3, and the pro-apoptotic molecule Bax PubMed
env Pre-treatment of endothelial cells with fibroblast growth factor 2 (FGF2) protects cells from HIV-1 gp120 angiotoxicity; this protection is regulated by crosstalk among the ERK, PI3K-AKT and PKC signaling pathways PubMed
env HIV-1 gp120 increases the levels of calcium-dependent and -independent PKC isozymes; the most striking change is observed in PKC-zeta isozyme levels PubMed
env A specific interaction between CD4 and HIV-1 gp120 is required for phosphorylation of CD4, which could involve protein kinase C PubMed
env IL-16 induces rapid translocation of PKC from the cytosol to the membrane in CD4+ cells; PKC inhibitors completely block IL-16-induced lymphocyte migration as well as the motile response induced by HIV-1 gp120 and anti-CD4 antibody binding to CD4 PubMed
Envelope transmembrane glycoprotein gp41 env A synthetic peptide corresponding to cytoplasmic domain residues 828-848 of HIV-1 gp41 inhibits pKC-catalysed phosphorylation of a protein substrate PubMed
env A synthetic peptide containing residues 581-597 from HIV-1 gp41 inhibits protein kinase C (pkC)-mediated phosphorylation of the CD3 gamma-chain in intact cells and directly inhibits partially purified pkC PubMed
Gag, Pr55 gag The phosphorylation of HIV-1 Gag by PRKCI regulates HIV-1 Vpr incorporation into virions and HIV-1 replication in macrophages PubMed
gag Immunoprecipation analysis demonstrates that PRKCZ binds HIV-1 Gag and phosphorylates Gag at position serine 487 in the p6 domain of Gag PubMed
gag The amplified luminescent proximity homogeneous assay (AlphaScreen) identifies the interaction of HIV-1 Gag with PRKCZ PubMed
Tat, p14 tat HIV-1 Tat increases CXCL12-induced internalization of CXCR4, and the Tat-mediated CXCR4 internalization requires activity of protein kinase C (zeta) PubMed
tat Phospholipase C/protein kinase C signaling pathway-dependent phosphorylation of p44/42 and JNK MAP kinases participates partially in IL-1beta induction by TAT PubMed
tat Protein kinase C is required for HIV-1 Tat-mediated transactivation of the viral LTR promoter, indicating protein kinase C regulates the process of HIV-1 transactivation and may play a role in the transition of HIV from latency to productive growth PubMed
tat Protein kinase C phosphorylates HIV-1 Tat on serine residue 46 PubMed
tat HIV-1 Tat activates protein kinase C, resulting in the induction of TNF-alpha, IL-6 and IL-10 expression and the secretion of MCP-1 PubMed
Vpr, p15 vpr The phosphorylation of HIV-1 Gag at Ser487 by PRKCZ regulates HIV-1 Vpr incorporation into virions and HIV-1 replication in macrophages PubMed
matrix gag Protein kinase C (PKC) phosphorylates HIV-1 Matrix on serine residue 111 resulting in a shift in localization of Matrix from the cytosol to the cellular membrane, suggesting a myristoyl-protein switch regulated by PKC phosphorylation PubMed
pol gag-pol Phosphorylation of human recombinant vimentin by PKC inhibits the proteolytic processing of the vimentin head domain by HIV-1 protease PubMed
gag-pol HIV-1 RT heterodimer expressed in bacteria can be phosphorylated in vitro by several purified mammalian protein kinases including auto-activated protein kinase (PK), CKII, cytosolic protamine kinase (CPK), myelin basic protein kinase 1 (MBPK1), and PRKC PubMed

Go to the HIV-1, Human Protein Interaction Database

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  • SMAD2/3 MH2 Domain Mutants in Cancer, organism-specific biosystem (from REACTOME)
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Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
14-3-3 protein binding IEA
Inferred from Electronic Annotation
more info
 
ATP binding IEA
Inferred from Electronic Annotation
more info
 
insulin receptor substrate binding IC
Inferred by Curator
more info
PubMed 
phospholipase binding IEA
Inferred from Electronic Annotation
more info
 
potassium channel regulator activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein domain specific binding IEA
Inferred from Electronic Annotation
more info
 
protein kinase C activity IEA
Inferred from Electronic Annotation
more info
 
protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein kinase binding IEA
Inferred from Electronic Annotation
more info
 
protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
actin cytoskeleton reorganization IEA
Inferred from Electronic Annotation
more info
 
activation of phospholipase D activity IEA
Inferred from Electronic Annotation
more info
 
activation of protein kinase B activity IEA
Inferred from Electronic Annotation
more info
 
blood coagulation TAS
Traceable Author Statement
more info
 
cell migration IEA
Inferred from Electronic Annotation
more info
 
establishment of cell polarity ISS
Inferred from Sequence or Structural Similarity
more info
 
inflammatory response IEA
Inferred from Electronic Annotation
more info
 
insulin receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
long-term memory IEA
Inferred from Electronic Annotation
more info
 
long-term synaptic potentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
membrane hyperpolarization IEA
Inferred from Electronic Annotation
more info
 
microtubule cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
 
negative regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
negative regulation of insulin receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of peptidyl-tyrosine phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of protein complex assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
peptidyl-serine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
platelet activation TAS
Traceable Author Statement
more info
 
positive regulation of ERK1 and ERK2 cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of NF-kappaB transcription factor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of T-helper 2 cell cytokine production ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of T-helper 2 cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of cell proliferation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cell-matrix adhesion IEA
Inferred from Electronic Annotation
more info
 
positive regulation of excitatory postsynaptic membrane potential ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of glucose import IEA
Inferred from Electronic Annotation
more info
 
positive regulation of insulin receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of interleukin-10 secretion ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of interleukin-13 secretion ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of interleukin-4 production ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of interleukin-5 secretion ISS
Inferred from Sequence or Structural Similarity
more info
 
protein heterooligomerization IEA
Inferred from Electronic Annotation
more info
 
protein kinase C signaling IEA
Inferred from Electronic Annotation
more info
 
protein localization to plasma membrane IEA
Inferred from Electronic Annotation
more info
 
protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
transforming growth factor beta receptor signaling pathway TAS
Traceable Author Statement
more info
 
vesicle transport along microtubule IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
apical cortex IEA
Inferred from Electronic Annotation
more info
 
apical plasma membrane IEA
Inferred from Electronic Annotation
more info
 
cell junction TAS
Traceable Author Statement
more info
 
cell leading edge IEA
Inferred from Electronic Annotation
more info
 
cell-cell junction IDA
Inferred from Direct Assay
more info
 
cytoplasm TAS
Traceable Author Statement
more info
PubMed 
cytosol IEA
Inferred from Electronic Annotation
more info
 
endosome IEA
Inferred from Electronic Annotation
more info
 
extracellular vesicular exosome IDA
Inferred from Direct Assay
more info
PubMed 
membrane TAS
Traceable Author Statement
more info
PubMed 
membrane raft IEA
Inferred from Electronic Annotation
more info
 
myelin sheath abaxonal region IEA
Inferred from Electronic Annotation
more info
 
nuclear envelope IEA
Inferred from Electronic Annotation
more info
 
nuclear matrix IEA
Inferred from Electronic Annotation
more info
 
perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
 
plasma membrane TAS
Traceable Author Statement
more info
PubMed 
protein complex IEA
Inferred from Electronic Annotation
more info
 
tight junction IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
protein kinase C zeta type
Names
protein kinase C zeta type
nPKC-zeta
NP_001028753.1
NP_001028754.1
NP_001229803.1
NP_002735.3

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029616.1 

    Range
    5001..139926
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001033581.1NP_001028753.1  protein kinase C zeta type isoform 2

    See proteins identical to NP_001028753.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and has multiple coding region differences, compared to variant 1. These differences cause translation initiation from a downstream ATG and an isoform (2) with a shorter N-terminus, compared to isoform 1. Variants 2 and 3 encode the same isoform (2).
    Source sequence(s)
    BC008058, CB152283
    Consensus CDS
    CCDS41229.1
    UniProtKB/Swiss-Prot
    Q05513
    Related
    ENSP00000383712, OTTHUMP00000220759, ENST00000400921, OTTHUMT00000098533
    Conserved Domains (3) summary
    cd05588
    Location:73399
    Blast Score: 1747
    STKc_aPKC; Catalytic domain of the Protein Serine/Threonine Kinase, Atypical Protein Kinase C
    smart00220
    Location:69335
    Blast Score: 747
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl17171
    Location:4598
    Blast Score: 82
    PH-like; Pleckstrin homology-like domain
  2. NM_001033582.1NP_001028754.1  protein kinase C zeta type isoform 2

    See proteins identical to NP_001028754.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and has multiple coding region differences, compared to variant 1. These differences cause translation initiation from a downstream ATG and an isoform (3) with a shorter N-terminus, compared to isoform 1. Variants 2 and 3 encode the same isoform (2).
    Source sequence(s)
    AL542576, AU134793, BC008058
    Consensus CDS
    CCDS41229.1
    UniProtKB/Swiss-Prot
    Q05513
    Related
    ENSP00000383711, ENST00000400920
    Conserved Domains (3) summary
    cd05588
    Location:73399
    Blast Score: 1747
    STKc_aPKC; Catalytic domain of the Protein Serine/Threonine Kinase, Atypical Protein Kinase C
    smart00220
    Location:69335
    Blast Score: 747
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl17171
    Location:4598
    Blast Score: 82
    PH-like; Pleckstrin homology-like domain
  3. NM_001242874.1NP_001229803.1  protein kinase C zeta type isoform 3

    See proteins identical to NP_001229803.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (3) has a shorter and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AK294782, AL590822, BC008058, DC312466
    Consensus CDS
    CCDS55563.1
    UniProtKB/Swiss-Prot
    Q05513
    Related
    ENSP00000426412, OTTHUMP00000196802, ENST00000461106, OTTHUMT00000317171
    Conserved Domains (4) summary
    cd05617
    Location:152478
    Blast Score: 1771
    STKc_aPKC_zeta; Catalytic domain of the Protein Serine/Threonine Kinase, Atypical Protein Kinase C zeta
    smart00220
    Location:148414
    Blast Score: 746
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd00029
    Location:2776
    Blast Score: 191
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cl17171
    Location:124177
    Blast Score: 82
    PH-like; Pleckstrin homology-like domain
  4. NM_002744.4NP_002735.3  protein kinase C zeta type isoform 1

    See proteins identical to NP_002735.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    BC008058, BC014270
    Consensus CDS
    CCDS37.1
    UniProtKB/Swiss-Prot
    Q05513
    Related
    ENSP00000367830, OTTHUMP00000001368, ENST00000378567, OTTHUMT00000003648
    Conserved Domains (5) summary
    cd06404
    Location:1698
    Blast Score: 393
    PB1_aPKC; PB1 domain is an essential modular domain of the atypical protein kinase C (aPKC) which in complex with Par6 and Par3 proteins is crucial for establishment of apical-basal polarity of animal cells. PB1 domain is a modular domain mediating specific ...
    cd05588
    Location:256582
    Blast Score: 1776
    STKc_aPKC; Catalytic domain of the Protein Serine/Threonine Kinase, Atypical Protein Kinase C
    smart00220
    Location:252518
    Blast Score: 752
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd00029
    Location:131180
    Blast Score: 186
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cl17171
    Location:228281
    Blast Score: 83
    PH-like; Pleckstrin homology-like domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000001.11 

    Range
    2050470..2185395
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006710766.1XP_006710829.1  

    Conserved Domains (5) summary
    cd06404
    Location:1698
    Blast Score: 396
    PB1_aPKC; PB1 domain is an essential modular domain of the atypical protein kinase C (aPKC) which in complex with Par6 and Par3 proteins is crucial for establishment of apical-basal polarity of animal cells. PB1 domain is a modular domain mediating specific ...
    smart00220
    Location:252518
    Blast Score: 749
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd00029
    Location:131180
    Blast Score: 180
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cl09925
    Location:256526
    Blast Score: 1510
    PKc_like; Protein Kinases, catalytic domain
    cl17171
    Location:228281
    Blast Score: 82
    PH-like; Pleckstrin homology-like domain
  2. XM_006710765.1XP_006710828.1  

    Conserved Domains (5) summary
    cd05617
    Location:209535
    Blast Score: 1774
    STKc_aPKC_zeta; Catalytic domain of the Protein Serine/Threonine Kinase, Atypical Protein Kinase C zeta
    smart00220
    Location:205471
    Blast Score: 749
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd00029
    Location:84133
    Blast Score: 188
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cl02720
    Location:1664
    Blast Score: 217
    PB1; The PB1 domain is a modular domain mediating specific protein-protein interactions which play a role in many critical cell processes, such as osteoclastogenesis, angiogenesis, early cardiovascular development, and cell polarity. A canonical PB1-PB1 ...
    cl17171
    Location:181234
    Blast Score: 82
    PH-like; Pleckstrin homology-like domain
  3. XM_006710764.1XP_006710827.1  

    Conserved Domains (5) summary
    cd05617
    Location:210536
    Blast Score: 1773
    STKc_aPKC_zeta; Catalytic domain of the Protein Serine/Threonine Kinase, Atypical Protein Kinase C zeta
    smart00220
    Location:206472
    Blast Score: 749
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd00029
    Location:85134
    Blast Score: 185
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cl02720
    Location:152
    Blast Score: 263
    PB1; The PB1 domain is a modular domain mediating specific protein-protein interactions which play a role in many critical cell processes, such as osteoclastogenesis, angiogenesis, early cardiovascular development, and cell polarity. A canonical PB1-PB1 ...
    cl17171
    Location:182235
    Blast Score: 82
    PH-like; Pleckstrin homology-like domain
  4. XM_006710767.1XP_006710830.1  

    See proteins identical to XP_006710830.1

    UniProtKB/Swiss-Prot
    Q05513
    Conserved Domains (3) summary
    cd05588
    Location:73399
    Blast Score: 1747
    STKc_aPKC; Catalytic domain of the Protein Serine/Threonine Kinase, Atypical Protein Kinase C
    smart00220
    Location:69335
    Blast Score: 747
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl17171
    Location:4598
    Blast Score: 82
    PH-like; Pleckstrin homology-like domain
  5. XM_006710768.1XP_006710831.1  

    Conserved Domains (3) summary
    cd05588
    Location:69395
    Blast Score: 1747
    STKc_aPKC; Catalytic domain of the Protein Serine/Threonine Kinase, Atypical Protein Kinase C
    smart00220
    Location:65331
    Blast Score: 746
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl17171
    Location:4194
    Blast Score: 82
    PH-like; Pleckstrin homology-like domain

Alternate HuRef

Genomic

  1. AC_000133.1 

    Range
    1259190..1392660
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018912.2 

    Range
    1969035..2101756
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

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