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    IL25 interleukin 25 [ Homo sapiens (human) ]

    Gene ID: 64806, updated on 5-Jul-2015
    Official Symbol
    IL25provided by HGNC
    Official Full Name
    interleukin 25provided by HGNC
    Primary source
    HGNC:HGNC:13765
    See related
    Ensembl:ENSG00000166090; HPRD:05742; MIM:605658; Vega:OTTHUMG00000028749
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    IL17E
    Summary
    The protein encoded by this gene is a cytokine that shares sequence similarity with interleukin 17. This cytokine can induce NF-kappaB activation, and stimulate the production of interleukin 8. Both this cytokine and interleukin 17B are ligands for the cytokine receptor IL17BR. Studies of a similar gene in mice suggest that this cytokine may be a pro-inflammatory cytokine favoring the Th2-type immune response. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]
    Orthologs
    See IL25 in Epigenomics, MapViewer
    Location:
    14q11.2
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    107 current GRCh38.p2 (GCF_000001405.28) 14 NC_000014.9 (23372809..23376403)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (23842018..23845612)

    Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene solute carrier family 22, member 17 Neighboring gene embryonal Fyn-associated substrate Neighboring gene CKLF-like MARVEL transmembrane domain containing 5 Neighboring gene myosin, heavy chain 6, cardiac muscle, alpha Neighboring gene microRNA 208a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    NHGRI GWAS Catalog

    Description
    A genome-wide meta-analysis of six type 1 diabetes cohorts identifies multiple associated loci.
    NHGRI GWA Catalog
    • Cytokine-cytokine receptor interaction, organism-specific biosystem (from KEGG)
      Cytokine-cytokine receptor interaction, organism-specific biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
    • Cytokine-cytokine receptor interaction, conserved biosystem (from KEGG)
      Cytokine-cytokine receptor interaction, conserved biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
    • IL17 signaling pathway, organism-specific biosystem (from WikiPathways)
      IL17 signaling pathway, organism-specific biosystemInterleukin 17 is a family of cytokines that acts as potent mediators in delayed-type reactions by increasing chemokine production in various tissues to recruit monocytes and neutrophils to the site ...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    cytokine activity IEA
    Inferred from Electronic Annotation
    more info
     
    interleukin-17E receptor binding TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    biological_process ND
    No biological Data available
    more info
     
    eosinophil differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    inflammatory response to antigenic stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of transcription from RNA polymerase II promoter IEA
    Inferred from Electronic Annotation
    more info
     
    response to fungus IEA
    Inferred from Electronic Annotation
    more info
     
    response to nematode IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    extracellular space IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    interleukin-25
    Names
    interleukin-17E

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_022789.3NP_073626.1  interleukin-25 isoform 1 precursor

      See identical proteins and their annotated locations for NP_073626.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes a longer isoform (1).
      Source sequence(s)
      AF305200, AL049829
      Consensus CDS
      CCDS9597.1
      UniProtKB/Swiss-Prot
      Q9H293
      Related
      ENSP00000328111, OTTHUMP00000027946, ENST00000329715, OTTHUMT00000071789
      Conserved Domains (1) summary
      pfam06083
      Location:84172
      IL17; Interleukin-17
    2. NM_172314.1NP_758525.1  interleukin-25 isoform 2 precursor

      See identical proteins and their annotated locations for NP_758525.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and uses an alternate start codon, compared to variant 1. The resulting isoform (2) has a distinct N-terminus and is shorter than isoform 1.
      Source sequence(s)
      AF305200, AF461739, AL049829
      Consensus CDS
      CCDS45086.1
      UniProtKB/Swiss-Prot
      Q9H293
      Conserved Domains (1) summary
      pfam06083
      Location:68156
      IL17; Interleukin-17

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p2 Primary Assembly

    Genomic

    1. NC_000014.9 Reference GRCh38.p2 Primary Assembly

      Range
      23372809..23376403
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.1

    Genomic

    1. NC_018925.2 Alternate CHM1_1.1

      Range
      23840690..23844284
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)