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    PRKCZ protein kinase C zeta [ Homo sapiens (human) ]

    Gene ID: 5590, updated on 19-Jul-2016
    Official Symbol
    PRKCZprovided by HGNC
    Official Full Name
    protein kinase C zetaprovided by HGNC
    Primary source
    HGNC:HGNC:9412
    See related
    Ensembl:ENSG00000067606 HPRD:01504; MIM:176982; Vega:OTTHUMG00000001238
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PKC2; PKC-ZETA
    Summary
    Protein kinase C (PKC) zeta is a member of the PKC family of serine/threonine kinases which are involved in a variety of cellular processes such as proliferation, differentiation and secretion. Unlike the classical PKC isoenzymes which are calcium-dependent, PKC zeta exhibits a kinase activity which is independent of calcium and diacylglycerol but not of phosphatidylserine. Furthermore, it is insensitive to typical PKC inhibitors and cannot be activated by phorbol ester. Unlike the classical PKC isoenzymes, it has only a single zinc finger module. These structural and biochemical properties indicate that the zeta subspecies is related to, but distinct from other isoenzymes of PKC. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
    Orthologs
    Location:
    1p36.33-p36.2
    Exon count:
    30
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 1 NC_000001.11 (2050470..2185395)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (1981909..2116834)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105378590 Neighboring gene uncharacterized LOC105378591 Neighboring gene uncharacterized LOC100506504 Neighboring gene Fanconi anemia core complex associated protein 20 Neighboring gene uncharacterized LOC105378593 Neighboring gene uncharacterized LOC105378592 Neighboring gene SKI proto-oncogene

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    NHGRI GWAS Catalog

    Description
    Genome-wide pharmacogenomic study of neurocognition as an indicator of antipsychotic treatment response in schizophrenia.
    NHGRI GWA Catalog
    Hundreds of variants clustered in genomic loci and biological pathways affect human height.
    NHGRI GWA Catalog

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV-1 gp120 activates forward trafficking and surface clustering of NMDA receptors in membrane microdomains by a PKA-dependent phosphorylation of the NR1 C-terminal Ser897, followed by a PKC-dependent phosphorylation of Ser896 PubMed
    env Down modulation of the interaction between HIV-1 gp120 and CD4 by TPA is blocked by protein kinase C (PKC) inhibitors, suggesting PKC may play an important role in HIV-1 infection PubMed
    env c-FLIPL inhibits Bax activation via modulating PKC expression at the transcriptional level involving AP-2 during gp120 treatment PubMed
    env Induction of apoptosis in cell cultures through binding of HIV-1 gp120 or gp160 to CXCR4 involves protein kinase C, basic fibroblast growth factor, caspase-3, and the pro-apoptotic molecule Bax PubMed
    env Pre-treatment of endothelial cells with fibroblast growth factor 2 (FGF2) protects cells from HIV-1 gp120 angiotoxicity; this protection is regulated by crosstalk among the ERK, PI3K-AKT and PKC signaling pathways PubMed
    env HIV-1 gp120 increases the levels of calcium-dependent and -independent PKC isozymes; the most striking change is observed in PKC-zeta isozyme levels PubMed
    env A specific interaction between CD4 and HIV-1 gp120 is required for phosphorylation of CD4, which could involve protein kinase C PubMed
    env IL-16 induces rapid translocation of PKC from the cytosol to the membrane in CD4+ cells; PKC inhibitors completely block IL-16-induced lymphocyte migration as well as the motile response induced by HIV-1 gp120 and anti-CD4 antibody binding to CD4 PubMed
    Envelope surface glycoprotein gp160, precursor env HIV-1 gp160-induced AP-1 complex formation is dependent upon protein tyrosine phosphorylation and is abolished by inhibitors of protein kinase C, but it is unaffected by calcium channel blockers or cyclosporine A PubMed
    Envelope transmembrane glycoprotein gp41 env A synthetic peptide corresponding to cytoplasmic domain residues 828-848 of HIV-1 gp41 inhibits pKC-catalysed phosphorylation of a protein substrate PubMed
    env A synthetic peptide containing residues 581-597 from HIV-1 gp41 inhibits protein kinase C (pkC)-mediated phosphorylation of the CD3 gamma-chain in intact cells and directly inhibits partially purified pkC PubMed
    Pr55(Gag) gag The phosphorylation of HIV-1 Gag by PRKCI regulates HIV-1 Vpr incorporation into virions and HIV-1 replication in macrophages PubMed
    gag Immunoprecipation analysis demonstrates that PRKCZ binds HIV-1 Gag and phosphorylates Gag at position serine 487 in the p6 domain of Gag PubMed
    gag The amplified luminescent proximity homogeneous assay (AlphaScreen) identifies the interaction of HIV-1 Gag with PRKCZ PubMed
    Tat tat HIV-1 Tat increases CXCL12-induced internalization of CXCR4, and the Tat-mediated CXCR4 internalization requires activity of protein kinase C (zeta) PubMed
    tat Phospholipase C/protein kinase C signaling pathway-dependent phosphorylation of p44/42 and JNK MAP kinases participates partially in IL-1beta induction by TAT PubMed
    tat Protein kinase C is required for HIV-1 Tat-mediated transactivation of the viral LTR promoter, indicating protein kinase C regulates the process of HIV-1 transactivation and may play a role in the transition of HIV from latency to productive growth PubMed
    tat Protein kinase C phosphorylates HIV-1 Tat on serine residue 46 PubMed
    tat HIV-1 Tat activates protein kinase C, resulting in the induction of TNF-alpha, IL-6 and IL-10 expression and the secretion of MCP-1 PubMed
    Vpr vpr The phosphorylation of HIV-1 Gag at Ser487 by PRKCZ regulates HIV-1 Vpr incorporation into virions and HIV-1 replication in macrophages PubMed
    matrix gag Protein kinase C (PKC) phosphorylates HIV-1 Matrix on serine residue 111 resulting in a shift in localization of Matrix from the cytosol to the cellular membrane, suggesting a myristoyl-protein switch regulated by PKC phosphorylation PubMed
    retropepsin gag-pol Phosphorylation of human recombinant vimentin by PKC inhibits the proteolytic processing of the vimentin head domain by HIV-1 protease PubMed
    reverse transcriptase gag-pol HIV-1 RT heterodimer expressed in bacteria can be phosphorylated in vitro by several purified mammalian protein kinases including auto-activated protein kinase (PK), CKII, cytosolic protamine kinase (CPK), myelin basic protein kinase 1 (MBPK1), and PRKC PubMed

    Go to the HIV-1, Human Interaction Database

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    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    14-3-3 protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    insulin receptor substrate binding IC
    Inferred by Curator
    more info
    PubMed 
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    phospholipase binding IEA
    Inferred from Electronic Annotation
    more info
     
    potassium channel regulator activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein domain specific binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein kinase C activity TAS
    Traceable Author Statement
    more info
     
    protein kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein kinase binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein serine/threonine kinase activity EXP
    Inferred from Experiment
    more info
    PubMed 
    protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    actin cytoskeleton reorganization IEA
    Inferred from Electronic Annotation
    more info
     
    activation of phospholipase D activity IEA
    Inferred from Electronic Annotation
    more info
     
    activation of protein kinase B activity IEA
    Inferred from Electronic Annotation
    more info
     
    cell migration IEA
    Inferred from Electronic Annotation
    more info
     
    establishment of cell polarity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    inflammatory response IEA
    Inferred from Electronic Annotation
    more info
     
    insulin receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    long-term memory IEA
    Inferred from Electronic Annotation
    more info
     
    long-term synaptic potentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    membrane depolarization IEA
    Inferred from Electronic Annotation
    more info
     
    membrane hyperpolarization IEA
    Inferred from Electronic Annotation
    more info
     
    microtubule cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of insulin receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of peptidyl-tyrosine phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of protein complex assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    neuron projection extension IEA
    Inferred from Electronic Annotation
    more info
     
    peptidyl-serine phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of ERK1 and ERK2 cascade IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of NF-kappaB transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of T-helper 2 cell cytokine production ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of T-helper 2 cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of cell-matrix adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of excitatory postsynaptic potential ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of glucose import IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of insulin receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of interleukin-10 secretion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of interleukin-13 secretion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of interleukin-4 production ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of interleukin-5 secretion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    protein heterooligomerization IEA
    Inferred from Electronic Annotation
    more info
     
    protein kinase C signaling IEA
    Inferred from Electronic Annotation
    more info
     
    protein localization to plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    transforming growth factor beta receptor signaling pathway TAS
    Traceable Author Statement
    more info
     
    vesicle transport along microtubule IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    apical cortex IEA
    Inferred from Electronic Annotation
    more info
     
    apical plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    axon hillock IEA
    Inferred from Electronic Annotation
    more info
     
    bicellular tight junction IEA
    Inferred from Electronic Annotation
    more info
     
    cell junction TAS
    Traceable Author Statement
    more info
     
    cell leading edge IEA
    Inferred from Electronic Annotation
    more info
     
    cell-cell junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm TAS
    Traceable Author Statement
    more info
    PubMed 
    cytosol TAS
    Traceable Author Statement
    more info
     
    endosome IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular exosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    filamentous actin IEA
    Inferred from Electronic Annotation
    more info
     
    membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    membrane raft IEA
    Inferred from Electronic Annotation
    more info
     
    microtubule organizing center IEA
    Inferred from Electronic Annotation
    more info
     
    myelin sheath abaxonal region IEA
    Inferred from Electronic Annotation
    more info
     
    nuclear envelope IEA
    Inferred from Electronic Annotation
    more info
     
    nuclear matrix IEA
    Inferred from Electronic Annotation
    more info
     
    perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    protein kinase C zeta type
    Names
    nPKC-zeta
    protein kinase C, zeta
    NP_001028753.1
    NP_001028754.1
    NP_001229803.1
    NP_002735.3

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029616.1 RefSeqGene

      Range
      5001..139926
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001033581.1NP_001028753.1  protein kinase C zeta type isoform 2

      See identical proteins and their annotated locations for NP_001028753.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and has multiple coding region differences, compared to variant 1. These differences cause translation initiation from a downstream ATG and an isoform (2) with a shorter N-terminus, compared to isoform 1. Variants 2 and 3 encode the same isoform (2).
      Source sequence(s)
      BC008058, CB152283
      Consensus CDS
      CCDS41229.1
      UniProtKB/Swiss-Prot
      Q05513
      Related
      ENSP00000383712, OTTHUMP00000220759, ENST00000400921, OTTHUMT00000098533
      Conserved Domains (2) summary
      smart00220
      Location:69335
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:53409
      PKc_like; Protein Kinases, catalytic domain
    2. NM_001033582.1NP_001028754.1  protein kinase C zeta type isoform 2

      See identical proteins and their annotated locations for NP_001028754.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and has multiple coding region differences, compared to variant 1. These differences cause translation initiation from a downstream ATG and an isoform (3) with a shorter N-terminus, compared to isoform 1. Variants 2 and 3 encode the same isoform (2).
      Source sequence(s)
      AL542576, AU134793, BC008058
      Consensus CDS
      CCDS41229.1
      UniProtKB/Swiss-Prot
      Q05513
      Related
      ENSP00000383711, ENST00000400920
      Conserved Domains (2) summary
      smart00220
      Location:69335
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:53409
      PKc_like; Protein Kinases, catalytic domain
    3. NM_001242874.1NP_001229803.1  protein kinase C zeta type isoform 3

      See identical proteins and their annotated locations for NP_001229803.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (3) has a shorter and distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AK294782, AL590822, BC008058, DC312466
      Consensus CDS
      CCDS55563.1
      UniProtKB/Swiss-Prot
      Q05513
      Related
      ENSP00000426412, OTTHUMP00000196802, ENST00000461106, OTTHUMT00000317171
      Conserved Domains (3) summary
      smart00220
      Location:148414
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd00029
      Location:2776
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cl21453
      Location:132488
      PKc_like; Protein Kinases, catalytic domain
    4. NM_002744.4NP_002735.3  protein kinase C zeta type isoform 1

      See identical proteins and their annotated locations for NP_002735.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      BC008058, BC014270
      Consensus CDS
      CCDS37.1
      UniProtKB/Swiss-Prot
      Q05513
      Related
      ENSP00000367830, OTTHUMP00000001368, ENST00000378567, OTTHUMT00000003648
      Conserved Domains (4) summary
      cd06404
      Location:1698
      PB1_aPKC; PB1 domain is an essential modular domain of the atypical protein kinase C (aPKC) which in complex with Par6 and Par3 proteins is crucial for establishment of apical-basal polarity of animal cells. PB1 domain is a modular domain mediating specific ...
      smart00220
      Location:252518
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd00029
      Location:131180
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd05617
      Location:236592
      STKc_aPKC_zeta; Catalytic domain of the Serine/Threonine Kinase, Atypical Protein Kinase C zeta

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p7 Primary Assembly

      Range
      2050470..2185395
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017001790.1XP_016857279.1  

    2. XM_017001789.1XP_016857278.1  

    3. XM_011541773.1XP_011540075.1  

      Conserved Domains (4) summary
      cd06404
      Location:1698
      PB1_aPKC; PB1 domain is an essential modular domain of the atypical protein kinase C (aPKC) which in complex with Par6 and Par3 proteins is crucial for establishment of apical-basal polarity of animal cells. PB1 domain is a modular domain mediating specific ...
      smart00220
      Location:252518
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd00029
      Location:131180
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cl21453
      Location:236529
      PKc_like; Protein Kinases, catalytic domain
    4. XM_011541775.2XP_011540077.1  

      Conserved Domains (3) summary
      cd06404
      Location:1698
      PB1_aPKC; PB1 domain is an essential modular domain of the atypical protein kinase C (aPKC) which in complex with Par6 and Par3 proteins is crucial for establishment of apical-basal polarity of animal cells. PB1 domain is a modular domain mediating specific ...
      cd00029
      Location:131180
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cl21453
      Location:236325
      PKc_like; Protein Kinases, catalytic domain
    5. XM_017001803.1XP_016857292.1  

    6. XM_017001796.1XP_016857285.1  

    7. XM_017001802.1XP_016857291.1  

    8. XM_017001792.1XP_016857281.1  

    9. XM_011541776.1XP_011540078.1  

      See identical proteins and their annotated locations for XP_011540078.1

      Conserved Domains (2) summary
      smart00220
      Location:69335
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:53346
      PKc_like; Protein Kinases, catalytic domain
    10. XM_017001804.1XP_016857293.1  

    11. XM_011541774.1XP_011540076.1  

      Conserved Domains (3) summary
      smart00220
      Location:148414
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd00029
      Location:2776
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cl21453
      Location:132425
      PKc_like; Protein Kinases, catalytic domain
    12. XM_017001805.1XP_016857294.1  

    13. XM_017001791.1XP_016857280.1  

    14. XM_017001798.1XP_016857287.1  

    15. XM_017001794.1XP_016857283.1  

    16. XM_011541778.1XP_011540080.1  

      See identical proteins and their annotated locations for XP_011540080.1

      Conserved Domains (2) summary
      smart00220
      Location:69335
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:53346
      PKc_like; Protein Kinases, catalytic domain
    17. XM_017001793.1XP_016857282.1  

    18. XM_017001799.1XP_016857288.1  

    19. XM_017001795.1XP_016857284.1  

    20. XM_017001801.1XP_016857290.1  

    21. XM_017001797.1XP_016857286.1  

    22. XM_017001800.1XP_016857289.1  

    RNA

    1. XR_001737313.1 RNA Sequence

    2. XR_946707.1 RNA Sequence

    3. XR_001737314.1 RNA Sequence

    4. XR_001737315.1 RNA Sequence

      Related
      ENST00000478770, OTTHUMT00000100282

    Alternate CHM1_1.1

    Genomic

    1. NC_018912.2 Alternate CHM1_1.1

      Range
      1969035..2101756
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)