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MARCH6 membrane-associated ring finger (C3HC4) 6, E3 ubiquitin protein ligase [ Homo sapiens (human) ]

Gene ID: 10299, updated on 11-Sep-2014
Official Symbol
MARCH6provided by HGNC
Official Full Name
membrane-associated ring finger (C3HC4) 6, E3 ubiquitin protein ligaseprovided by HGNC
Primary source
HGNC:HGNC:30550
See related
Ensembl:ENSG00000145495; HPRD:11095; MIM:613297; Vega:OTTHUMG00000162027
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TEB4; DOA10; RNF176; MARCH-VI
Summary
This gene encodes a member of a family of membrane-associated E3 ubiquitin ligases containing RING-CH-type zinc finger motifs. Ubiquitination of type II deiodinase by the encoded protein is an important regulatory step in thyroid hormone signalling. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]
See MARCH6 in Epigenomics, MapViewer
Location:
5p15.2
Exon count:
26
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 5 NC_000005.10 (10353639..10440388)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (10353751..10440500)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene chaperonin containing TCP1, subunit 5 (epsilon) Neighboring gene carboxymethylenebutenolidase homolog (Pseudomonas) Neighboring gene uncharacterized LOC101929977 Neighboring gene ROPN1L antisense RNA 1 Neighboring gene rhophilin associated tail protein 1-like Neighboring gene uncharacterized LOC101929379

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
A novel locus for body mass index on 5p15.2: a meta-analysis of two genome-wide association studies.
NHGRI GWA Catalog
  • Protein processing in endoplasmic reticulum, organism-specific biosystem (from KEGG)
    Protein processing in endoplasmic reticulum, organism-specific biosystemThe endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylate...
  • Protein processing in endoplasmic reticulum, conserved biosystem (from KEGG)
    Protein processing in endoplasmic reticulum, conserved biosystemThe endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylate...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • KIAA0597, DKFZp586L081

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
ligase activity IEA
Inferred from Electronic Annotation
more info
 
ubiquitin conjugating enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
ubiquitin-protein transferase activity IDA
Inferred from Direct Assay
more info
PubMed 
ubiquitin-protein transferase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
protein K48-linked ubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
integral component of endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
PubMed 
membrane IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
E3 ubiquitin-protein ligase MARCH6
Names
E3 ubiquitin-protein ligase MARCH6
doa10 homolog
RING finger protein 176
membrane-associated RING-CH protein VI
membrane-associated RING finger protein 6
membrane-associated RING-CH finger protein 6
NP_001257589.1
NP_001257590.1
NP_005876.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001270660.1NP_001257589.1  E3 ubiquitin-protein ligase MARCH6 isoform 2

    See proteins identical to NP_001257589.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AC092336, AK300034, BX116291, DB072938
    Consensus CDS
    CCDS59487.1
    UniProtKB/Swiss-Prot
    O60337
    Conserved Domains (1) summary
    smart00744
    Location:856
    RINGv; The RING-variant domain is a C4HC3 zinc-finger like motif found in a number of cellular and viral proteins
  2. NM_001270661.1NP_001257590.1  E3 ubiquitin-protein ligase MARCH6 isoform 3

    See proteins identical to NP_001257590.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks three alternate in-frame exons in the coding region, compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
    Source sequence(s)
    AC092336, AK296585, BX116291, DB072938
    Consensus CDS
    CCDS59488.1
    UniProtKB/Swiss-Prot
    O60337
    Conserved Domains (1) summary
    COG5183
    Location:277788
    SSM4; Protein involved in mRNA turnover and stability [RNA processing and modification]
  3. NM_005885.3NP_005876.2  E3 ubiquitin-protein ligase MARCH6 isoform 1

    See proteins identical to NP_005876.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AB011169, AC092336, BX116291, DB072938
    Consensus CDS
    CCDS34135.1
    UniProtKB/Swiss-Prot
    O60337
    Related
    ENSP00000274140, OTTHUMP00000221092, ENST00000274140, OTTHUMT00000366919
    Conserved Domains (1) summary
    smart00744
    Location:856
    RINGv; The RING-variant domain is a C4HC3 zinc-finger like motif found in a number of cellular and viral proteins

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000005.10 

    Range
    10353639..10440388
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

  1. AC_000137.1 

    Range
    10338021..10424590
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018916.2 

    Range
    10353128..10440366
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)