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    TTK TTK protein kinase [ Homo sapiens (human) ]

    Gene ID: 7272, updated on 24-Sep-2016
    Official Symbol
    TTKprovided by HGNC
    Official Full Name
    TTK protein kinaseprovided by HGNC
    Primary source
    HGNC:HGNC:12401
    See related
    Ensembl:ENSG00000112742 HPRD:04973; MIM:604092; Vega:OTTHUMG00000015088
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ESK; PYT; CT96; MPH1; MPS1; MPS1L1
    Summary
    This gene encodes a dual specificity protein kinase with the ability to phosphorylate tyrosine, serine and threonine. Associated with cell proliferation, this protein is essential for chromosome alignment at the centromere during mitosis and is required for centrosome duplication. It has been found to be a critical mitotic checkpoint protein for accurate segregation of chromosomes during mitosis. Tumorigenesis may occur when this protein fails to degrade and produces excess centrosomes resulting in aberrant mitotic spindles. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2009]
    Orthologs
    Location:
    6q14.1
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 6 NC_000006.12 (80004147..80043577)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (80714322..80752244)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107986616 Neighboring gene glyceraldehyde 3 phosphate dehydrogenase pseudogene 63 Neighboring gene ribosomal protein L35a pseudogene 18 Neighboring gene Rho GTPase activating protein 21 pseudogene Neighboring gene adenylate kinase 4 pseudogene 5

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    • Cell cycle, organism-specific biosystem (from KEGG)
      Cell cycle, organism-specific biosystemMitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. Cycli...
    • Cell cycle, conserved biosystem (from KEGG)
      Cell cycle, conserved biosystemMitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. Cycli...
    • RB in Cancer, organism-specific biosystem (from WikiPathways)
      RB in Cancer, organism-specific biosystem
      RB in Cancer
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • FLJ38280

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein serine/threonine/tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    chromosome separation IEA
    Inferred from Electronic Annotation
    more info
     
    mitotic spindle assembly checkpoint TAS
    Traceable Author Statement
    more info
    PubMed 
    mitotic spindle organization TAS
    Traceable Author Statement
    more info
    PubMed 
    peptidyl-tyrosine phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of cell proliferation TAS
    Traceable Author Statement
    more info
    PubMed 
    positive regulation of pathway-restricted SMAD protein phosphorylation TAS
    Traceable Author Statement
    more info
    PubMed 
    spindle organization TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    spindle TAS
    Traceable Author Statement
    more info
    PubMed 
    Preferred Names
    dual specificity protein kinase TTK
    Names
    cancer/testis antigen 96
    monopolar spindle 1 kinase
    monopolar spindle 1-like 1
    phosphotyrosine picked threonine kinase
    phosphotyrosine picked threonine-protein kinase
    NP_001160163.1
    NP_003309.2

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001166691.1NP_001160163.1  dual specificity protein kinase TTK isoform 2

      See identical proteins and their annotated locations for NP_001160163.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses alternate in-frame splice sites in the 5' UTR and in the central coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
      Source sequence(s)
      AK292460, AL133475, AU154042, DA853919
      Consensus CDS
      CCDS55040.1
      UniProtKB/Swiss-Prot
      P33981
      Related
      ENSP00000230510, OTTHUMP00000016778, ENST00000230510, OTTHUMT00000041317
      Conserved Domains (2) summary
      cd14131
      Location:522790
      PKc_Mps1; Catalytic domain of the Dual-specificity Mitotic checkpoint protein kinase, Monopolar spindle 1 (also called TTK)
      pfam00069
      Location:524790
      Pkinase; Protein kinase domain
    2. NM_003318.4NP_003309.2  dual specificity protein kinase TTK isoform 1

      See identical proteins and their annotated locations for NP_003309.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the shorter transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK315696, AU154042, DA853919
      Consensus CDS
      CCDS4993.1
      UniProtKB/Swiss-Prot
      P33981
      Related
      ENSP00000358813, OTTHUMP00000016777, ENST00000369798, OTTHUMT00000041316
      Conserved Domains (2) summary
      cd14131
      Location:523791
      PKc_Mps1; Catalytic domain of the Dual-specificity Mitotic checkpoint protein kinase, Monopolar spindle 1 (also called TTK)
      pfam00069
      Location:525791
      Pkinase; Protein kinase domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p7 Primary Assembly

      Range
      80004147..80043577
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017011242.1XP_016866731.1  

    2. XM_011536100.2XP_011534402.1  

      See identical proteins and their annotated locations for XP_011534402.1

      UniProtKB/Swiss-Prot
      P33981
      Related
      ENSP00000422936, OTTHUMP00000220743, ENST00000509894, OTTHUMT00000366101
      Conserved Domains (2) summary
      cd14131
      Location:522790
      PKc_Mps1; Catalytic domain of the Dual-specificity Mitotic checkpoint protein kinase, Monopolar spindle 1 (also called TTK)
      pfam00069
      Location:524790
      Pkinase; Protein kinase domain
    3. XM_011536099.2XP_011534401.1  

      See identical proteins and their annotated locations for XP_011534401.1

      UniProtKB/Swiss-Prot
      P33981
      Conserved Domains (2) summary
      cd14131
      Location:523791
      PKc_Mps1; Catalytic domain of the Dual-specificity Mitotic checkpoint protein kinase, Monopolar spindle 1 (also called TTK)
      pfam00069
      Location:525791
      Pkinase; Protein kinase domain

    Alternate CHM1_1.1

    Genomic

    1. NC_018917.2 Alternate CHM1_1.1

      Range
      80811776..80849705
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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