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    EEA1 early endosome antigen 1 [ Homo sapiens (human) ]

    Gene ID: 8411, updated on 23-Aug-2016
    Official Symbol
    EEA1provided by HGNC
    Official Full Name
    early endosome antigen 1provided by HGNC
    Primary source
    HGNC:HGNC:3185
    See related
    Ensembl:ENSG00000102189 HPRD:05460; MIM:605070; Vega:OTTHUMG00000170110
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MST105; ZFYVE2; MSTP105
    Orthologs
    Location:
    12q22
    Exon count:
    32
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 12 NC_000012.12 (92772509..92975228, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (93166285..93323107, complement)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene chromosome 12 open reading frame 74 Neighboring gene pleckstrin homology and RhoGEF domain containing G7 Neighboring gene s-adenosylmethionine synthase isoform type-2-like Neighboring gene heterogeneous nuclear ribonucleoprotein A1 pseudogene 50 Neighboring gene RNA, U6 small nuclear 1329, pseudogene Neighboring gene uncharacterized LOC105369906 Neighboring gene uncharacterized LOC643339 Neighboring gene developmental pluripotency associated 3 pseudogene

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV-1 gp120 co-localizes with EEA-1 in human plasmacytoid dendritic cells PubMed
    Envelope surface glycoprotein gp160, precursor env HIV-1 Env co-localizes with EEA1 in early endosomes PubMed
    Pr55(Gag) gag HIV-1 Gag and viral RNA co-localize with EEA1 in early endosomes PubMed
    gag Myristoylated Gag co-localizes with EEA1 in early endosomes PubMed
    Vpr vpr A stable-isotope labeling by amino acids in cell culture coupled with mass spectrometry-based proteomics identifies upregulation of early endosome antigen 1 (EEA1) expression by HIV-1 Vpr in Vpr transduced macrophages PubMed
    Vpu vpu Expression of HIV-1 Vpu induces co-localization of tetherin with early endosome protein EEA-1 or late endosome protein LAMP-1 PubMed

    Go to the HIV-1, Human Interaction Database

    • Endocytosis, organism-specific biosystem (from KEGG)
      Endocytosis, organism-specific biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
    • Endocytosis, conserved biosystem (from KEGG)
      Endocytosis, conserved biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    • Innate Immune System, organism-specific biosystem (from REACTOME)
      Innate Immune System, organism-specific biosystemInnate immunity encompases the nonspecific part of immunity tha are part of an individual's natural biologic makeup
    • Phagosome, organism-specific biosystem (from KEGG)
      Phagosome, organism-specific biosystemPhagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is...
    • Phagosome, conserved biosystem (from KEGG)
      Phagosome, conserved biosystemPhagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is...
    • Toll Like Receptor 9 (TLR9) Cascade, organism-specific biosystem (from REACTOME)
      Toll Like Receptor 9 (TLR9) Cascade, organism-specific biosystemCpG DNA is an unusual Pathogen-Associated Molecular Pattern (PAMP). Cytosine methylation exists in mammalian but not bacterial cells, and most (but not all) CpG in the mammalian genome is methylated....
    • Toll-Like Receptors Cascades, organism-specific biosystem (from REACTOME)
      Toll-Like Receptors Cascades, organism-specific biosystemIn human, ten members of the Toll-like receptor (TLR) family (TLR1-TLR10) have been identified (TLR11 has been found in mouse, but not in human). All TLRs have a similar Toll/IL-1 receptor (TIR) doma...
    • Tuberculosis, organism-specific biosystem (from KEGG)
      Tuberculosis, organism-specific biosystemTuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent...
    • Tuberculosis, conserved biosystem (from KEGG)
      Tuberculosis, conserved biosystemTuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    1-phosphatidylinositol binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    GTP-dependent protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    calmodulin binding NAS
    Non-traceable Author Statement
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    zinc ion binding TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    early endosome to late endosome transport NAS
    Non-traceable Author Statement
    more info
    PubMed 
    endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    synaptic vesicle to endosome fusion TAS
    Traceable Author Statement
    more info
    PubMed 
    vesicle fusion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    axonal spine IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasm TAS
    Traceable Author Statement
    more info
    PubMed 
    cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    early endosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    early endosome membrane IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular exosome IDA
    Inferred from Direct Assay
    more info
     
    extrinsic component of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    presynapse IEA
    Inferred from Electronic Annotation
    more info
     
    recycling endosome IEA
    Inferred from Electronic Annotation
    more info
     
    serine-pyruvate aminotransferase complex IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    early endosome antigen 1
    Names
    early endosome antigen 1, 162kD
    early endosome-associated protein
    endosome-associated protein p162
    zinc finger FYVE domain-containing protein 2

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_003566.3NP_003557.2  early endosome antigen 1

      See identical proteins and their annotated locations for NP_003557.2

      Status: VALIDATED

      Source sequence(s)
      AC016136, BF515615, BP228986, X78998
      Consensus CDS
      CCDS31874.1
      UniProtKB/Swiss-Prot
      Q15075
      Related
      ENSP00000317955, OTTHUMP00000242845, ENST00000322349, OTTHUMT00000407304
      Conserved Domains (3) summary
      cd15730
      Location:13471409
      FYVE_EEA1; FYVE domain found in early endosome antigen 1 (EEA1) and similar proteins
      pfam01576
      Location:2661340
      Myosin_tail_1; Myosin tail
      cl19219
      Location:383477
      DUF342; Protein of unknown function (DUF342)

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p7 Primary Assembly

      Range
      92772509..92975228 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017020018.1XP_016875507.1  

    2. XM_011538814.2XP_011537116.1  

      Conserved Domains (3) summary
      pfam01576
      Location:2121035
      Myosin_tail_1; Myosin tail
      TIGR02168
      Location:7381397
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      cd15730
      Location:13891451
      FYVE_EEA1; FYVE domain found in early endosome antigen 1 (EEA1) and similar proteins
    3. XM_011538815.2XP_011537117.1  

      Conserved Domains (3) summary
      pfam01576
      Location:124947
      Myosin_tail_1; Myosin tail
      TIGR02168
      Location:6501309
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      cd15730
      Location:13011363
      FYVE_EEA1; FYVE domain found in early endosome antigen 1 (EEA1) and similar proteins

    Alternate CHM1_1.1

    Genomic

    1. NC_018923.2 Alternate CHM1_1.1

      Range
      93130989..93288076 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)