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TRIOBP TRIO and F-actin binding protein [ Homo sapiens (human) ]

Gene ID: 11078, updated on 12-Apr-2015
Official Symbol
TRIOBPprovided by HGNC
Official Full Name
TRIO and F-actin binding proteinprovided by HGNC
Primary source
HGNC:HGNC:17009
See related
Ensembl:ENSG00000100106; HPRD:11028; MIM:609761; Vega:OTTHUMG00000150657
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TARA; TAP68; DFNB28; dJ37E16.4; HRIHFB2122
Summary
This gene encodes a protein with an N-terminal pleckstrin homology domain and a C-terminal coiled-coil region. The protein interacts with trio, which is involved with neural tissue development and controlling actin cytoskeleton organization, cell motility and cell growth. The protein also associates with F-actin and stabilizes F-actin structures. Mutations in this gene have been associated with a form of autosomal recessive nonsyndromic deafness. Multiple alternatively spliced transcript variants that would encode different isoforms have been found for this gene, however some transcripts may be subject to nonsense-mediated decay (NMD). [provided by RefSeq, Nov 2008]
Orthologs
See TRIOBP in MapViewer
Location:
22q13.1
Exon count:
26
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 22 NC_000022.11 (37696988..37776556)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (38092995..38172563)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene lectin, galactoside-binding, soluble, 1 Neighboring gene nucleolar protein 12 Neighboring gene uncharacterized LOC102724378 Neighboring gene H1 histone family, member 0 Neighboring gene glycine C-acetyltransferase

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Potential readthrough

Included gene: NOL12

Homology

Clone Names

  • FLJ39315, KIAA1662

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GTP-Rho binding NAS
Non-traceable Author Statement
more info
PubMed 
actin filament binding IDA
Inferred from Direct Assay
more info
PubMed 
myosin II binding NAS
Non-traceable Author Statement
more info
PubMed 
ubiquitin protein ligase binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
actin modification NAS
Non-traceable Author Statement
more info
PubMed 
barbed-end actin filament capping NAS
Non-traceable Author Statement
more info
PubMed 
cell division IEA
Inferred from Electronic Annotation
more info
 
mitotic nuclear division IEA
Inferred from Electronic Annotation
more info
 
positive regulation of substrate adhesion-dependent cell spreading IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
actin cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 
actin cytoskeleton NAS
Non-traceable Author Statement
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
 
focal adhesion IDA
Inferred from Direct Assay
more info
PubMed 
microtubule organizing center IEA
Inferred from Electronic Annotation
more info
 
midbody IEA
Inferred from Electronic Annotation
more info
 
nucleus IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
TRIO and F-actin-binding protein
Names
TRIO and F-actin-binding protein
protein Tara
tara-like protein
trio-associated repeat on actin

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012857.1 RefSeqGene

    Range
    5001..84569
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001039141.2NP_001034230.1  TRIO and F-actin-binding protein isoform 6

    See identical proteins and their annotated locations for NP_001034230.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) represents the longest transcript and encodes the longest protein (isoform 6).
    Source sequence(s)
    AW444985, DA790674, DQ228005, Z83844
    Consensus CDS
    CCDS43015.1
    UniProtKB/Swiss-Prot
    Q9H2D6
    Related
    ENSP00000384312, OTTHUMP00000198149, ENST00000406386, OTTHUMT00000319439
    Conserved Domains (3) summary
    pfam04514
    Location:19772113
    BTV_NS2; Bluetongue virus non-structural protein NS2
    cd00176
    Location:20652258
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd13275
    Location:17811895
    PH_M-RIP; Myosin phosphatase-RhoA Interacting Protein Pleckstrin homology (PH) domain
  2. NM_007032.5NP_008963.3  TRIO and F-actin-binding protein isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) contains a distinct 5' UTR and lacks an in-frame portion of the 5' coding region, compared to variant 6. The resulting isoform (1) has a shorter N-terminus when compared to isoform 6.
    Source sequence(s)
    AW444985, BC003618, BQ880866, DQ228003, Z83844
    Consensus CDS
    CCDS43016.1
    UniProtKB/Swiss-Prot
    Q9H2D6
    Conserved Domains (2) summary
    pfam04514
    Location:264400
    BTV_NS2; Bluetongue virus non-structural protein NS2
    cd13275
    Location:68182
    PH_M-RIP; Myosin phosphatase-RhoA Interacting Protein Pleckstrin homology (PH) domain
  3. NM_138632.2NP_619538.2  TRIO and F-actin-binding protein isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, 3' UTR, and coding region (compared to variant 6), resulting in a protein that has shorter and distinct N- and C-termini when it is compared to isoform 6.
    Source sequence(s)
    BC003618, BC022200, BQ880866, BU621193
    Consensus CDS
    CCDS33644.1
    UniProtKB/Swiss-Prot
    Q9H2D6
    Related
    ENSP00000383913, OTTHUMP00000198152, ENST00000407319, OTTHUMT00000319443
    Conserved Domains (2) summary
    pfam04514
    Location:264425
    BTV_NS2; Bluetongue virus non-structural protein NS2
    cd13275
    Location:68182
    PH_M-RIP; Myosin phosphatase-RhoA Interacting Protein Pleckstrin homology (PH) domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p2 Primary Assembly

    Range
    37696988..37776556
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018933.2 Alternate CHM1_1.1

    Range
    38051700..38131297
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)