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TREM2 triggering receptor expressed on myeloid cells 2 [ Homo sapiens (human) ]

Gene ID: 54209, updated on 1-Mar-2015
Official Symbol
TREM2provided by HGNC
Official Full Name
triggering receptor expressed on myeloid cells 2provided by HGNC
Primary source
HGNC:HGNC:17761
See related
Ensembl:ENSG00000095970; HPRD:05473; MIM:605086; Vega:OTTHUMG00000014671
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TREM-2; Trem2a; Trem2b; Trem2c
Summary
This gene encodes a membrane protein that forms a receptor signaling complex with the TYRO protein tyrosine kinase binding protein. The encoded protein functions in immune response and may be involved in chronic inflammation by triggering the production of constitutive inflammatory cytokines. Defects in this gene are a cause of polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Nov 2012]
Orthologs
See TREM2 in MapViewer
Location:
6p21.1
Exon count:
5
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 6 NC_000006.12 (41158506..41163186, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (41126244..41130924, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene nuclear transcription factor Y, alpha Neighboring gene adenylate cyclase 10 (soluble) pseudogene 1 Neighboring gene triggering receptor expressed on myeloid cells-like 1 Neighboring gene triggering receptor expressed on myeloid cells-like 2 Neighboring gene triggering receptor expressed on myeloid cells-like 3, pseudogene

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Genome-wide association and population genetic analysis of C-reactive protein in African American and Hispanic American women.
NHGRI GWA Catalog
Variant of TREM2 associated with the risk of Alzheimer's disease.
NHGRI GWA Catalog

Protein interactions

Protein Gene Interaction Pubs
Envelope transmembrane glycoprotein gp41 env A synthetic peptide corresponding to the immunosuppressive domain (amino acids 574-592) of HIV-1 gp41 downregulates the expression of triggering receptor expressed on myeloid cells 2 (TREM2) in peptide-treated PBMCs PubMed

Go to the HIV-1, Human Interaction Database

  • Axon guidance, organism-specific biosystem (from REACTOME)
    Axon guidance, organism-specific biosystemAxon guidance / axon pathfinding is the process by which neurons send out axons to reach the correct targets. Growing axons have a highly motile structure at the growing tip called the growth cone, w...
  • DAP12 interactions, organism-specific biosystem (from REACTOME)
    DAP12 interactions, organism-specific biosystemDNAX activation protein of 12kDa (DAP12) is an immunoreceptor tyrosine-based activation motif (ITAM)-bearing adapter molecule that transduces activating signals in natural killer (NK) and myeloid cel...
  • DAP12 signaling, organism-specific biosystem (from REACTOME)
    DAP12 signaling, organism-specific biosystemIn response to receptor ligation, the tyrosine residues in DAP12's immunoreceptor tyrosine-based activation motif (ITAM) are phosphorylated by Src family kinases. These phosphotyrosines form the dock...
  • Developmental Biology, organism-specific biosystem (from REACTOME)
    Developmental Biology, organism-specific biosystemAs a first step towards capturing the array of processes by which a fertilized egg gives rise to the diverse tissues of the body, examples of three kinds of processes have been annotated. These are a...
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
  • Innate Immune System, organism-specific biosystem (from REACTOME)
    Innate Immune System, organism-specific biosystemInnate immunity encompases the nonspecific part of immunity tha are part of an individual's natural biologic makeup
  • Osteoclast differentiation, organism-specific biosystem (from KEGG)
    Osteoclast differentiation, organism-specific biosystemThe osteoclasts, multinucleared cells originating from the hematopoietic monocyte-macrophage lineage, are responsible for bone resorption. Osteoclastogenesis is mainly regulated by signaling pathways...
  • Osteoclast differentiation, conserved biosystem (from KEGG)
    Osteoclast differentiation, conserved biosystemThe osteoclasts, multinucleared cells originating from the hematopoietic monocyte-macrophage lineage, are responsible for bone resorption. Osteoclastogenesis is mainly regulated by signaling pathways...
  • Other semaphorin interactions, organism-specific biosystem (from REACTOME)
    Other semaphorin interactions, organism-specific biosystemThere are eight classes of semaphorins and four types of plexins. Semaphorin (SEMA) classes 1 and 2 are found in invertebrates and classes 3-7 are vertebrate sempahorines. Sempahorin class 3 is secre...
  • Semaphorin interactions, organism-specific biosystem (from REACTOME)
    Semaphorin interactions, organism-specific biosystemSemaphorins are a large family of cell surface and secreted guidance molecules divided into eight classes on the basis of their structures. They all have an N-terminal conserved sema domain. Semaphor...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
lipopolysaccharide binding IEA
Inferred from Electronic Annotation
more info
 
lipoteichoic acid binding IEA
Inferred from Electronic Annotation
more info
 
peptidoglycan binding IEA
Inferred from Electronic Annotation
more info
 
receptor activity TAS
Traceable Author Statement
more info
PubMed 
scaffold protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
extracellular region IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane IDA
Inferred from Direct Assay
more info
PubMed 
intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 
Preferred Names
triggering receptor expressed on myeloid cells 2
Names
triggering receptor expressed on myeloid cells 2
triggering receptor expressed on monocytes 2
triggering receptor expressed on myeloid cells 2a

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_011561.1 RefSeqGene

    Range
    4999..9679
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_631

mRNA and Protein(s)

  1. NM_001271821.1NP_001258750.1  triggering receptor expressed on myeloid cells 2 precursor isoform 2 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2), alternately referred to as TREM-2V, lacks a 3' coding exon which results in a frameshift, compared to variant 1. The resulting isoform (2) is shorter compared to isoform 1.
    Source sequence(s)
    AB062787, BC032362
    Consensus CDS
    CCDS64422.1
    UniProtKB/Swiss-Prot
    Q9NZC2
    Related
    ENSP00000342651, OTTHUMP00000016369, ENST00000338469, OTTHUMT00000040500
    Conserved Domains (2) summary
    smart00410
    Location:26111
    IG_like; Immunoglobulin like
    cl11960
    Location:23128
    Ig; Immunoglobulin domain
  2. NM_018965.3NP_061838.1  triggering receptor expressed on myeloid cells 2 precursor isoform 1 precursor

    See proteins identical to NP_061838.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AB062787, AF213457, BC032362
    Consensus CDS
    CCDS4852.1
    UniProtKB/TrEMBL
    Q5TCX1
    UniProtKB/Swiss-Prot
    Q9NZC2
    Related
    ENSP00000362205, OTTHUMP00000016368, ENST00000373113, OTTHUMT00000040499
    Conserved Domains (2) summary
    smart00410
    Location:26111
    IG_like; Immunoglobulin like
    cl11960
    Location:23128
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38 Primary Assembly

    Range
    41158506..41163186
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006715116.1XP_006715179.1  

Alternate CHM1_1.1

Genomic

  1. NC_018917.2 Alternate CHM1_1.1

    Range
    41129139..41133819
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

  1. AC_000138.1 Alternate HuRef

    Range
    40844044..40848724
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)