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    MED25 mediator complex subunit 25 [ Homo sapiens (human) ]

    Gene ID: 81857, updated on 26-Jul-2015
    Official Symbol
    MED25provided by HGNC
    Official Full Name
    mediator complex subunit 25provided by HGNC
    Primary source
    HGNC:HGNC:28845
    See related
    Ensembl:ENSG00000104973; HPRD:14380; MIM:610197; Vega:OTTHUMG00000183161
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    P78; ACID1; ARC92; BVSYS; PTOV2; CMT2B2; TCBAP0758
    Summary
    This gene encodes a component of the transcriptional coactivator complex termed the Mediator complex. This complex is required for transcription of most RNA polymerase II-dependent genes. The encoded protein plays a role in chromatin modification and in preinitiation complex assembly. Mutations in this gene are associated with Charcot-Marie-Tooth disease type 2B2. [provided by RefSeq, Apr 2010]
    Orthologs
    See MED25 in Epigenomics, MapViewer
    Location:
    19q13.3
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    107 current GRCh38.p2 (GCF_000001405.28) 19 NC_000019.10 (49818279..49840384)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (50321319..50340237)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene adaptor-related protein complex 2, alpha 1 subunit Neighboring gene microRNA 6799 Neighboring gene uncharacterized LOC105372435 Neighboring gene fuzzy planar cell polarity protein Neighboring gene microRNA 6800 Neighboring gene PTOV1 antisense RNA 1 Neighboring gene prostate tumor overexpressed 1 Neighboring gene PTOV1 antisense RNA 2 Neighboring gene microRNA 4749

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Associated conditions

    Description Tests
    BASEL-VANAGAITE-SMIRIN-YOSEF SYNDROME
    MedGen: CN231442 OMIM: 616449 GeneReviews: Not available
    not available
    Charcot-Marie-Tooth disease type 2B2 Compare labs

    NHGRI GWAS Catalog

    Description
    Genome-wide association study identifies loci affecting blood copper, selenium and zinc.
    NHGRI GWA Catalog
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    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • MGC70671, DKFZp434K0512

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    retinoic acid receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    retinoid X receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    nuclear transcription factor complex IEA
    Inferred from Electronic Annotation
    more info
     
    nucleoplasm TAS
    Traceable Author Statement
    more info
     
    Preferred Names
    mediator of RNA polymerase II transcription subunit 25
    Names
    ARC/mediator transcriptional coactivator subunit
    activator interaction domain-containing protein 1
    activator-recruited cofactor 92 kDa component
    mediator of RNA polymerase II transcription, subunit 25 homolog
    prostate-derived protein 78 kDa

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_017091.1 RefSeqGene

      Range
      5001..23702
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_368

    mRNA and Protein(s)

    1. NM_030973.3NP_112235.2  mediator of RNA polymerase II transcription subunit 25

      See identical proteins and their annotated locations for NP_112235.2

      Status: REVIEWED

      Source sequence(s)
      BC065297, BG770032, DC410997
      Consensus CDS
      CCDS33075.1
      UniProtKB/Swiss-Prot
      Q71SY5
      Related
      ENSP00000326767, OTTHUMP00000271001, ENST00000312865, OTTHUMT00000465316
      Conserved Domains (4) summary
      pfam11232
      Location:392545
      Med25; Mediator complex subunit 25 PTOV activation and synapsin 2
      pfam11235
      Location:228385
      Med25_SD1; Mediator complex subunit 25 synapsin 1
      pfam11265
      Location:1227
      Med25_VWA; Mediator complex subunit 25 von Willebrand factor type A
      cl21632
      Location:669742
      DUF1720; Domain of unknown function (DUF1720)

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p2 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p2 Primary Assembly

      Range
      49818279..49840384
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011527353.1XP_011525655.1  

      Conserved Domains (3) summary
      pfam11232
      Location:392545
      Med25; Mediator complex subunit 25 PTOV activation and synapsin 2
      pfam11235
      Location:228385
      Med25_SD1; Mediator complex subunit 25 synapsin 1
      pfam11265
      Location:1227
      Med25_VWA; Mediator complex subunit 25 von Willebrand factor type A

    Alternate CHM1_1.1

    Genomic

    1. NC_018930.2 Alternate CHM1_1.1

      Range
      50323376..50342077
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)