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    PRKD2 protein kinase D2 [ Homo sapiens (human) ]

    Gene ID: 25865, updated on 9-Jun-2016
    Official Symbol
    PRKD2provided by HGNC
    Official Full Name
    protein kinase D2provided by HGNC
    Primary source
    HGNC:HGNC:17293
    See related
    Ensembl:ENSG00000105287 HPRD:09523; MIM:607074; Vega:OTTHUMG00000183431
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PKD2; HSPC187; nPKC-D2
    Summary
    The protein encoded by this gene belongs to the protein kinase D (PKD) family of serine/threonine protein kinases. This kinase can be activated by phorbol esters as well as by gastrin via the cholecystokinin B receptor (CCKBR) in gastric cancer cells. It can bind to diacylglycerol (DAG) in the trans-Golgi network (TGN) and may regulate basolateral membrane protein exit from TGN. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
    Orthologs
    Location:
    19q13.3
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 19 NC_000019.10 (46674316..46717127, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (47177573..47220384, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene G protein subunit gamma 8 Neighboring gene dishevelled binding antagonist of beta catenin 3 Neighboring gene DACT3 antisense RNA 1 Neighboring gene RNA, 7SL, cytoplasmic 364, pseudogene Neighboring gene uncharacterized LOC107987269 Neighboring gene microRNA 320e Neighboring gene striatin 4 Neighboring gene fukutin related protein Neighboring gene solute carrier family 1 member 5

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    NHGRI GWAS Catalog

    Description
    A genome-wide association study identifies six susceptibility loci for chronic lymphocytic leukemia.
    NHGRI GWA Catalog
    Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes.
    NHGRI GWA Catalog
    • Aldosterone synthesis and secretion, organism-specific biosystem (from KEGG)
      Aldosterone synthesis and secretion, organism-specific biosystemAldosterone is a steroid hormone synthesized in and secreted from the outer layer of the adrenal cortex, the zona glomerulosa. Aldosterone plays an important role in the regulation of systemic blood ...
    • Aldosterone synthesis and secretion, conserved biosystem (from KEGG)
      Aldosterone synthesis and secretion, conserved biosystemAldosterone is a steroid hormone synthesized in and secreted from the outer layer of the adrenal cortex, the zona glomerulosa. Aldosterone plays an important role in the regulation of systemic blood ...
    • Rap1 signaling pathway, organism-specific biosystem (from KEGG)
      Rap1 signaling pathway, organism-specific biosystemRap1 is a small GTPase that controls diverse processes, such as cell adhesion, cell-cell junction formation and cell polarity. Like all G proteins, Rap1 cycles between an inactive GDP-bound and an ac...
    • Rap1 signaling pathway, conserved biosystem (from KEGG)
      Rap1 signaling pathway, conserved biosystemRap1 is a small GTPase that controls diverse processes, such as cell adhesion, cell-cell junction formation and cell polarity. Like all G proteins, Rap1 cycles between an inactive GDP-bound and an ac...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase C activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein serine/threonine kinase activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    T cell receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    adaptive immune response IEA
    Inferred from Electronic Annotation
    more info
     
    angiogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    cell death IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cellular response to vascular endothelial growth factor stimulus IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    cellular response to vascular endothelial growth factor stimulus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    endothelial tube morphogenesis TAS
    Traceable Author Statement
    more info
    PubMed 
    intracellular signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mitophagy in response to mitochondrial depolarization IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    peptidyl-serine phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of CREB transcription factor activity IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of DNA biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of ERK1 and ERK2 cascade ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of NF-kappaB transcription factor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of T cell receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of angiogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of angiogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of blood vessel endothelial cell migration IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of blood vessel endothelial cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of cell adhesion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of endothelial cell chemotaxis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of endothelial cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of endothelial cell proliferation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of endothelial cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of fibroblast growth factor receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of histone deacetylase activity IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of interleukin-2 production ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of interleukin-8 production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of intracellular signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of peptidyl-serine phosphorylation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of sequence-specific DNA binding transcription factor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of transcription from RNA polymerase II promoter IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of transcription from RNA polymerase II promoter IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of vascular endothelial growth factor receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein autophosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein autophosphorylation TAS
    Traceable Author Statement
    more info
    PubMed 
    protein kinase D signaling IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein phosphorylation NAS
    Non-traceable Author Statement
    more info
    PubMed 
    vascular endothelial growth factor receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    serine/threonine-protein kinase D2
    NP_001073349.1
    NP_001073350.1
    NP_001073351.1
    NP_057541.2

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001079880.1NP_001073349.1  serine/threonine-protein kinase D2 isoform A

      See identical proteins and their annotated locations for NP_001073349.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 3 encode the same isoform (A).
      Source sequence(s)
      AC008635, AF309082, AL050147
      Consensus CDS
      CCDS12689.1
      UniProtKB/Swiss-Prot
      Q9BZL6
      Related
      ENSP00000393978, ENST00000433867
      Conserved Domains (4) summary
      smart00220
      Location:555807
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd00029
      Location:265314
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd01239
      Location:391511
      PH_PKD; Protein kinase D (PKD/PKCmu) pleckstrin homology (PH) domain
      cd14082
      Location:547806
      STKc_PKD; Catalytic domain of the Serine/Threonine kinase, Protein Kinase D
    2. NM_001079881.1NP_001073350.1  serine/threonine-protein kinase D2 isoform A

      See identical proteins and their annotated locations for NP_001073350.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 3 encode the same isoform (A).
      Source sequence(s)
      AC008635, AF309082, AL050147
      Consensus CDS
      CCDS12689.1
      UniProtKB/Swiss-Prot
      Q9BZL6
      Related
      ENSP00000470804, OTTHUMP00000271663, ENST00000595515, OTTHUMT00000466597
      Conserved Domains (4) summary
      smart00220
      Location:555807
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd00029
      Location:265314
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd01239
      Location:391511
      PH_PKD; Protein kinase D (PKD/PKCmu) pleckstrin homology (PH) domain
      cd14082
      Location:547806
      STKc_PKD; Catalytic domain of the Serine/Threonine kinase, Protein Kinase D
    3. NM_001079882.1NP_001073351.1  serine/threonine-protein kinase D2 isoform B

      See identical proteins and their annotated locations for NP_001073351.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) contains a distinct 5' UTR and lacks an in-frame portion of the 5' coding region, compared to variant 1. The resulting isoform (B) has a shorter N-terminus when compared to isoform A.
      Source sequence(s)
      AF309082, AL050147, DA475821
      Consensus CDS
      CCDS59401.1
      UniProtKB/Swiss-Prot
      Q9BZL6
      Related
      ENSP00000472744, OTTHUMP00000271662, ENST00000600194, OTTHUMT00000466594
      Conserved Domains (5) summary
      smart00220
      Location:398650
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd00029
      Location:108157
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      pfam00130
      Location:131
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      cd01239
      Location:234354
      PH_PKD; Protein kinase D (PKD/PKCmu) pleckstrin homology (PH) domain
      cd14082
      Location:390649
      STKc_PKD; Catalytic domain of the Serine/Threonine kinase, Protein Kinase D
    4. NM_016457.4NP_057541.2  serine/threonine-protein kinase D2 isoform A

      See identical proteins and their annotated locations for NP_057541.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, and 3 encode the same isoform (A).
      Source sequence(s)
      AC008635, AF309082, AL050147
      Consensus CDS
      CCDS12689.1
      UniProtKB/Swiss-Prot
      Q9BZL6
      Related
      ENSP00000291281, OTTHUMP00000271661, ENST00000291281, OTTHUMT00000466591
      Conserved Domains (4) summary
      smart00220
      Location:555807
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd00029
      Location:265314
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd01239
      Location:391511
      PH_PKD; Protein kinase D (PKD/PKCmu) pleckstrin homology (PH) domain
      cd14082
      Location:547806
      STKc_PKD; Catalytic domain of the Serine/Threonine kinase, Protein Kinase D

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p7 Primary Assembly

      Range
      46674316..46717127 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005258716.2XP_005258773.2  

      See identical proteins and their annotated locations for XP_005258773.2

      UniProtKB/Swiss-Prot
      Q9BZL6
      Related
      ENSP00000469106, OTTHUMP00000271659, ENST00000601806, OTTHUMT00000466589
      Conserved Domains (5) summary
      smart00220
      Location:398650
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd00029
      Location:108157
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      pfam00130
      Location:131
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      cd01239
      Location:234354
      PH_PKD; Protein kinase D (PKD/PKCmu) pleckstrin homology (PH) domain
      cd14082
      Location:390649
      STKc_PKD; Catalytic domain of the Serine/Threonine kinase, Protein Kinase D

    Alternate CHM1_1.1

    Genomic

    1. NC_018930.2 Alternate CHM1_1.1

      Range
      47179449..47222284 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)