Display Settings:

Format

Send to:

Choose Destination

MEPE matrix extracellular phosphoglycoprotein [ Homo sapiens (human) ]

Gene ID: 56955, updated on 23-Jul-2014
Official Symbol
MEPEprovided by HGNC
Official Full Name
matrix extracellular phosphoglycoproteinprovided by HGNC
Primary source
HGNC:13361
See related
Ensembl:ENSG00000152595; HPRD:06908; MIM:605912; Vega:OTTHUMG00000130592
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
OF45
Summary
This gene encodes a secreted calcium-binding phosphoprotein that belongs to the small integrin-binding ligand, N-linked glycoprotein (SIBLING) family of proteins. Members of this family are components of the extracellular matrix of bone and dentin and regulate bone mineralization. Deficiency of a similar protein in mouse results in increased bone mass. Mice lacking this gene are resistant to aging-related trabecular bone loss. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]
See MEPE in Epigenomics, MapViewer
Location:
4q21.1
Exon count:
7
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 4 NC_000004.12 (87821411..87846817)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (88742563..88767969)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene coiled-coil-helix-coiled-coil-helix domain containing 2 pseudogene 7 Neighboring gene integrin-binding sialoprotein Neighboring gene heat shock protein 90kDa alpha (cytosolic), class B member 3, pseudogene Neighboring gene secreted phosphoprotein 1

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Genetic determinants of cardiovascular events among women with migraine: a genome-wide association study.
NHGRI GWA Catalog
Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture.
NHGRI GWA Catalog
GWAS of dental caries patterns in the permanent dentition.
NHGRI GWA Catalog
Multistage genome-wide association meta-analyses identified two new loci for bone mineral density.
NHGRI GWA Catalog
Twenty bone-mineral-density loci identified by large-scale meta-analysis of genome-wide association studies.
NHGRI GWA Catalog
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
extracellular matrix structural constituent TAS
Traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
biomineral tissue development IEA
Inferred from Electronic Annotation
more info
 
negative regulation of bone mineralization IEA
Inferred from Electronic Annotation
more info
 
regulation of bone remodeling IEA
Inferred from Electronic Annotation
more info
 
skeletal system development TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
proteinaceous extracellular matrix IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
matrix extracellular phosphoglycoprotein
Names
matrix extracellular phosphoglycoprotein
osteoblast/osteocyte factor 45
matrix, extracellular phosphoglycoprotein with ASARM motif (bone)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_034073.1 

    Range
    5001..30420
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001184694.2NP_001171623.1  matrix extracellular phosphoglycoprotein isoform a precursor

    See proteins identical to NP_001171623.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) lacks an in-frame exon in the 5' coding region compared to variant 6. The encoded isoform (a) is shorter than isoform c. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC093768, AJ276396, AK075076, CA436639
    Consensus CDS
    CCDS3625.1
    UniProtKB/TrEMBL
    Q8NC19
    UniProtKB/Swiss-Prot
    Q9NQ76
    Related
    ENSP00000416984, ENST00000424957
    Conserved Domains (1) summary
    pfam07175
    Location:76256
    Blast Score: 690
    Osteoregulin; Osteoregulin
  2. NM_001184695.1NP_001171624.1  matrix extracellular phosphoglycoprotein isoform b

    See proteins identical to NP_001171624.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an alternate exon and contains an alternate exon, resulting in the use of a downstream start codon compared to variant 6. The encoded isoform (b) has a shorter N-terminus compared to isoform c. Variants 3, 4, and 5 encode the same protein.
    Source sequence(s)
    AC093768, DC314534
    Consensus CDS
    CCDS54776.1
    UniProtKB/Swiss-Prot
    Q9NQ76
    Conserved Domains (1) summary
    pfam07175
    Location:1143
    Blast Score: 633
    Osteoregulin; Osteoregulin
  3. NM_001184696.1NP_001171625.1  matrix extracellular phosphoglycoprotein isoform b

    See proteins identical to NP_001171625.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks an alternate exon and contains an alternate exon, resulting in the use of a downstream start codon compared to variant 6. The encoded isoform (b) has a shorter N-terminus compared to isoform c. Variants 3, 4, and 5 encode the same protein.
    Source sequence(s)
    AC093768, AK307774, DC326111
    Consensus CDS
    CCDS54776.1
    UniProtKB/Swiss-Prot
    Q9NQ76
    Related
    ENSP00000443491, ENST00000540395
    Conserved Domains (1) summary
    pfam07175
    Location:1143
    Blast Score: 633
    Osteoregulin; Osteoregulin
  4. NM_001184697.1NP_001171626.1  matrix extracellular phosphoglycoprotein isoform b

    See proteins identical to NP_001171626.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) contains an alternate exon resulting in the use of a downstream start codon compared to variant 6. The encoded isoform (b) has a shorter N-terminus compared to isoform c. Variants 3, 4, and 5 encode the same protein.
    Source sequence(s)
    AC093768, AJ276396, AK307774
    Consensus CDS
    CCDS54776.1
    UniProtKB/Swiss-Prot
    Q9NQ76
    Related
    ENSP00000453994, ENST00000560249
    Conserved Domains (1) summary
    pfam07175
    Location:1143
    Blast Score: 633
    Osteoregulin; Osteoregulin
  5. NM_001291183.1NP_001278112.1  matrix extracellular phosphoglycoprotein isoform c precursor

    See proteins identical to NP_001278112.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) encodes the longest isoform (c).
    Source sequence(s)
    AC093768, DQ854717
    UniProtKB/Swiss-Prot
    Q9NQ76
    Conserved Domains (1) summary
    pfam07175
    Location:107287
    Blast Score: 695
    Osteoregulin; Osteoregulin
  6. NM_020203.3NP_064588.1  matrix extracellular phosphoglycoprotein isoform a precursor

    See proteins identical to NP_064588.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon in the 5' coding region compared to variant 6. The encoded isoform (a) is shorter than isoform c. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC093768, AF325916, AJ276396, AK307774
    Consensus CDS
    CCDS3625.1
    UniProtKB/Swiss-Prot
    Q9NQ76
    Related
    ENSP00000354341, OTTHUMP00000161166, ENST00000361056, OTTHUMT00000253038
    Conserved Domains (1) summary
    pfam07175
    Location:76256
    Blast Score: 690
    Osteoregulin; Osteoregulin

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000004.12 

    Range
    87821411..87846817
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006714278.1XP_006714341.1  

    See proteins identical to XP_006714341.1

    UniProtKB/Swiss-Prot
    Q9NQ76
    Conserved Domains (1) summary
    pfam07175
    Location:107287
    Blast Score: 695
    Osteoregulin; Osteoregulin

Alternate HuRef

Genomic

  1. AC_000136.1 

    Range
    84488173..84513583
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018915.2 

    Range
    88719352..88744756
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)