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    USP21 ubiquitin specific peptidase 21 [ Homo sapiens (human) ]

    Gene ID: 27005, updated on 3-Apr-2016
    Official Symbol
    USP21provided by HGNC
    Official Full Name
    ubiquitin specific peptidase 21provided by HGNC
    Primary source
    HGNC:HGNC:12620
    See related
    Ensembl:ENSG00000143258 HPRD:05291; MIM:604729; Vega:OTTHUMG00000033154
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    USP16; USP23
    Summary
    This gene encodes a member of the C19 peptidase family, also known as family 2 of ubiquitin carboxy-terminal hydrolases. The encoded protein cleaves ubiquitin from ubiquitinated proteins for recycling in intracellular protein degradation. The encoded protein is also able to release NEDD8, a ubiquitin-like protein, from NEDD8-conjugated proteins. This gene has been referred to as USP16 and USP23 but is now known as USP21. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2016]
    Orthologs
    Location:
    1q22
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    107 current GRCh38.p2 (GCF_000001405.28) 1 NC_000001.11 (161159464..161165726)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (161129248..161135516)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene nitrilase 1 Neighboring gene death effector domain containing Neighboring gene ubiquitin-fold modifier conjugating enzyme 1 Neighboring gene protoporphyrinogen oxidase Neighboring gene beta-1,4-galactosyltransferase 3 Neighboring gene ADAM metallopeptidase with thrombospondin type 1 motif 4 Neighboring gene NADH:ubiquinone oxidoreductase core subunit S2

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    • Death Receptor Signalling, organism-specific biosystem (from REACTOME)
      Death Receptor Signalling, organism-specific biosystemThe death receptors, all cell-surface receptors, begin the process of caspase activation. The common feature of these type 1 transmembrane proteins is the "death-domain" a conserved cytoplasmic motif...
    • Integrated Breast Cancer Pathway, organism-specific biosystem (from WikiPathways)
      Integrated Breast Cancer Pathway, organism-specific biosystemThis pathway incorporates the most important proteins for Breast Cancer. The Rp score from the Connectivity-Maps (C-Maps) webserver was used to determine the rank of the most important proteins in Br...
    • Regulation of TNFR1 signaling, organism-specific biosystem (from REACTOME)
      Regulation of TNFR1 signaling, organism-specific biosystemTumor necrosis factor-alpha (TNFalpha) is an inflammatory cytokine, that activates either cell survival (e.g.,inflammation, proliferation) or cell death upon association with TNF receptor 1 (TNFR1). ...
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • TNF signaling, organism-specific biosystem (from REACTOME)
      TNF signaling, organism-specific biosystemThe inflammatory cytokine tumor necrosis factor alpha (TNF-alpha) is expressed in immune and nonimmune cell types including macrophages, T cells, mast cells, granulocytes, natural killer (NK) cells, ...
    • TNFR1-induced NFkappaB signaling pathway, organism-specific biosystem (from REACTOME)
      TNFR1-induced NFkappaB signaling pathway, organism-specific biosystemActivation of tumor necrosis factor receptor 1 (TNFR1) can trigger multiple signal transduction pathways to induce inflammation, cell proliferation, survival or cell death (Ward C et al. 1999; Michea...
    • TNFR1-induced proapoptotic signaling, organism-specific biosystem (from REACTOME)
      TNFR1-induced proapoptotic signaling, organism-specific biosystemActivation of tumor necrosis factor receptor 1 (TNFR1) can trigger multiple signal transduction pathways to induce cell survival or cell death (Ward C et al. 1999; Micheau O and Tschopp J 2003; Wider...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • MGC3394

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    NEDD8-specific protease activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cysteine-type peptidase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cysteine-type peptidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    thiol-dependent ubiquitin-specific protease activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    thiol-dependent ubiquitin-specific protease activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    transcription coactivator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    histone deubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    neuron projection development IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of transcription, DNA-templated ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cellular_component ND
    No biological Data available
    more info
     
    cytoplasm IDA
    Inferred from Direct Assay
    more info
     
    nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    plasma membrane IDA
    Inferred from Direct Assay
    more info
     
    Preferred Names
    ubiquitin carboxyl-terminal hydrolase 21
    Names
    NEDD8-specific protease
    deubiquitinating enzyme 21
    ubiquitin specific protease 21
    ubiquitin thioesterase 21
    ubiquitin thiolesterase 21
    ubiquitin-specific processing protease 21
    ubiquitin-specific protease 16
    ubiquitin-specific-processing protease 21
    NP_001014443.1
    NP_036607.3

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001014443.2NP_001014443.1  ubiquitin carboxyl-terminal hydrolase 21 isoform c

      See identical proteins and their annotated locations for NP_001014443.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 4. The resulting isoform (c) is shorter at the N-terminus compared to isoform a. Variants 1 and 3 both encode the same isoform (c).
      Source sequence(s)
      AF177758, AI038040, BC090946, BI755746
      Consensus CDS
      CCDS30920.1
      UniProtKB/Swiss-Prot
      Q9UK80
      Related
      ENSP00000356981, ENST00000368002
      Conserved Domains (2) summary
      cd02674
      Location:213556
      Peptidase_C19R; A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      pfam00443
      Location:212555
      UCH; Ubiquitin carboxyl-terminal hydrolase
    2. NM_001319848.1NP_001306777.1  ubiquitin carboxyl-terminal hydrolase 21 isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR and coding sequence and uses an alternate in-frame splice junction in the 3' end compared to variant 4. The resulting isoform (b) is shorter at the N-terminus and lacks an alternate internal segment compared to isoform a.
      Source sequence(s)
      AF217979, AF233442, AI038040, DA000829
      Conserved Domains (3) summary
      cd02674
      Location:213542
      Peptidase_C19R; A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      pfam00443
      Location:212541
      UCH; Ubiquitin carboxyl-terminal hydrolase
      cl02553
      Location:212346
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    3. NM_012475.4NP_036607.3  ubiquitin carboxyl-terminal hydrolase 21 isoform c

      See identical proteins and their annotated locations for NP_036607.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) differs in the 5' UTR and coding sequence compared to variant 4. The resulting isoform (c) is shorter at the N-terminus compared to isoform a. Variants 1 and 3 both encode the same isoform (c).
      Source sequence(s)
      AF177758, AI038040, BI755746
      Consensus CDS
      CCDS30920.1
      UniProtKB/Swiss-Prot
      Q9UK80
      Related
      ENSP00000289865, OTTHUMP00000031883, ENST00000289865, OTTHUMT00000080801
      Conserved Domains (2) summary
      cd02674
      Location:213556
      Peptidase_C19R; A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      pfam00443
      Location:212555
      UCH; Ubiquitin carboxyl-terminal hydrolase

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p2 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p2 Primary Assembly

      Range
      161159464..161165726
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011509412.1XP_011507714.1  

      Conserved Domains (2) summary
      cd02674
      Location:242585
      Peptidase_C19R; A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      pfam00443
      Location:241584
      UCH; Ubiquitin carboxyl-terminal hydrolase
    2. XM_011509413.1XP_011507715.1  

      See identical proteins and their annotated locations for XP_011507715.1

      UniProtKB/Swiss-Prot
      Q9UK80
      Conserved Domains (2) summary
      cd02674
      Location:213556
      Peptidase_C19R; A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      pfam00443
      Location:212555
      UCH; Ubiquitin carboxyl-terminal hydrolase
    3. XM_011509414.1XP_011507716.1  

      Conserved Domains (2) summary
      pfam00443
      Location:241414
      UCH; Ubiquitin carboxyl-terminal hydrolase
      cl02553
      Location:240415
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    4. XM_006711274.1XP_006711337.1  

      See identical proteins and their annotated locations for XP_006711337.1

      Conserved Domains (2) summary
      cd02674
      Location:29372
      Peptidase_C19R; A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      pfam00443
      Location:28371
      UCH; Ubiquitin carboxyl-terminal hydrolase

    Alternate CHM1_1.1

    Genomic

    1. NC_018912.2 Alternate CHM1_1.1

      Range
      162525504..162531766
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)