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TNFRSF19 tumor necrosis factor receptor superfamily, member 19 [ Homo sapiens (human) ]

Gene ID: 55504, updated on 19-Jul-2014
Official Symbol
TNFRSF19provided by HGNC
Official Full Name
tumor necrosis factor receptor superfamily, member 19provided by HGNC
Primary source
HGNC:11915
Locus tag
UNQ1888/PRO4333
See related
Ensembl:ENSG00000127863; HPRD:05838; MIM:606122; Vega:OTTHUMG00000016568
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TAJ; TROY; TRADE; TAJ-alpha
Summary
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is highly expressed during embryonic development. It has been shown to interact with TRAF family members, and to activate JNK signaling pathway when overexpressed in cells. This receptor is capable of inducing apoptosis by a caspase-independent mechanism, and it is thought to play an essential role in embryonic development. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]
See TNFRSF19 in Epigenomics, MapViewer
Location:
13q12.11-q12.3
Exon count :
11
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 13 NC_000013.11 (23570370..23676105)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (24144509..24250244)

Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 327 Neighboring gene uncharacterized LOC101928839 Neighboring gene mitochondrial intermediate peptidase Neighboring gene MT-CO3 pseudogene 2 Neighboring gene C1QTNF9B antisense RNA 1 Neighboring gene C1q and tumor necrosis factor related protein 9B

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
A genome-wide association study of nasopharyngeal carcinoma identifies three new susceptibility loci.
NHGRI GWA Catalog
Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.
NHGRI GWA Catalog
Novel associations for hypothyroidism include known autoimmune risk loci.
NHGRI GWA Catalog
  • Cytokine-cytokine receptor interaction, organism-specific biosystem (from KEGG)
    Cytokine-cytokine receptor interaction, organism-specific biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
  • Cytokine-cytokine receptor interaction, conserved biosystem (from KEGG)
    Cytokine-cytokine receptor interaction, conserved biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
tumor necrosis factor-activated receptor activity NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
JNK cascade NAS
Non-traceable Author Statement
more info
PubMed 
apoptotic process NAS
Non-traceable Author Statement
more info
PubMed 
hair follicle development IEA
Inferred from Electronic Annotation
more info
 
positive regulation of I-kappaB kinase/NF-kappaB signaling RCA
inferred from Reviewed Computational Analysis
more info
PubMed 
tumor necrosis factor-mediated signaling pathway NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
integral component of membrane NAS
Non-traceable Author Statement
more info
PubMed 
Preferred Names
tumor necrosis factor receptor superfamily member 19
Names
tumor necrosis factor receptor superfamily member 19
toxicity and JNK inducer

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001204458.1NP_001191387.1  tumor necrosis factor receptor superfamily member 19 isoform 2 precursor

    See proteins identical to NP_001191387.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 3' end-region which includes a part of the coding sequence, as compared to variant 1. The resulting isoform (2) has a distinct and shorter C-terminus, as compared to isoform (1). Variants 2 and 3 encode the same isoform 2.
    Source sequence(s)
    AY358888, BC047321, BF968836, BF971156, BM801444, DB223760
    Consensus CDS
    CCDS9301.1
    UniProtKB/Swiss-Prot
    Q9NS68
    Related
    ENSP00000371698, OTTHUMP00000018114, ENST00000382263, OTTHUMT00000044157
    Conserved Domains (1) summary
    cd00185
    Location:34138
    Blast Score: 198
    TNFR; Tumor necrosis factor receptor (TNFR) domain; superfamily of TNF-like receptor domains. When bound to TNF-like cytokines, TNFRs trigger multiple signal transduction pathways, they are involved in inflammation response, apoptosis, autoimmunity and ...
  2. NM_001204459.1NP_001191388.1  tumor necrosis factor receptor superfamily member 19 isoform 3

    See proteins identical to NP_001191388.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' and 3' end-regions including UTRs and coding sequences, as compared to variant 1. The resulting isoform (3) has a shorter N-terminus and a distinct and shorter C-terminus, as compared to isoform 1.
    Source sequence(s)
    AK304290, AY358888, BC047321, BF968836, BF971156, BM801444, DA192370
    Consensus CDS
    CCDS55893.1
    UniProtKB/Swiss-Prot
    Q9NS68
  3. NM_018647.3NP_061117.2  tumor necrosis factor receptor superfamily member 19 isoform 1 precursor

    See proteins identical to NP_061117.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) is also called TRADEbeta. It encodes the longest isoform (1).
    Source sequence(s)
    AF167555, AL161422, BC047321, DB223760
    Consensus CDS
    CCDS9302.1
    UniProtKB/Swiss-Prot
    Q9NS68
    Related
    ENSP00000371693, OTTHUMP00000018113, ENST00000382258, OTTHUMT00000044156
    Conserved Domains (1) summary
    cd00185
    Location:34138
    Blast Score: 199
    TNFR; Tumor necrosis factor receptor (TNFR) domain; superfamily of TNF-like receptor domains. When bound to TNF-like cytokines, TNFRs trigger multiple signal transduction pathways, they are involved in inflammation response, apoptosis, autoimmunity and ...
  4. NM_148957.3NP_683760.1  tumor necrosis factor receptor superfamily member 19 isoform 2 precursor

    See proteins identical to NP_683760.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) is also called TRADEalpha. It has an alternate 5' UTR exon and differs in the 3' end-region which includes a part of the coding sequence, as compared to variant 1. The resulting isoform (2) has a distinct and shorter C-terminus, as compared to isoform (1). Variants 2 and 3 encode the same isoform 2.
    Source sequence(s)
    AY358888, BC047321, BF968836, BF971156, BM801444, DA192370
    Consensus CDS
    CCDS9301.1
    UniProtKB/Swiss-Prot
    Q9NS68
    Conserved Domains (1) summary
    cd00185
    Location:34138
    Blast Score: 198
    TNFR; Tumor necrosis factor receptor (TNFR) domain; superfamily of TNF-like receptor domains. When bound to TNF-like cytokines, TNFRs trigger multiple signal transduction pathways, they are involved in inflammation response, apoptosis, autoimmunity and ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000013.11 

    Range
    23570370..23676105
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005266446.1XP_005266503.1  

    See proteins identical to XP_005266503.1

    Conserved Domains (1) summary
    cd00185
    Location:34138
    Blast Score: 181
    TNFR; Tumor necrosis factor receptor (TNFR) domain; superfamily of TNF-like receptor domains. When bound to TNF-like cytokines, TNFRs trigger multiple signal transduction pathways, they are involved in inflammation response, apoptosis, autoimmunity and ...
  2. XM_005266445.1XP_005266502.1  

    See proteins identical to XP_005266502.1

    UniProtKB/Swiss-Prot
    Q9NS68
    Conserved Domains (1) summary
    cd00185
    Location:34138
    Blast Score: 199
    TNFR; Tumor necrosis factor receptor (TNFR) domain; superfamily of TNF-like receptor domains. When bound to TNF-like cytokines, TNFRs trigger multiple signal transduction pathways, they are involved in inflammation response, apoptosis, autoimmunity and ...

Alternate HuRef

Genomic

  1. AC_000145.1 

    Range
    4955857..5061345
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018924.2 

    Range
    24112757..24218407
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

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