Display Settings:

Format

Send to:

Choose Destination
We are sorry, but NCBI web applications do not support your browser and may not function properly. More information

BDNF brain-derived neurotrophic factor [ Homo sapiens (human) ]

Gene ID: 627, updated on 7-Jul-2014
Official Symbol
BDNFprovided by HGNC
Official Full Name
brain-derived neurotrophic factorprovided by HGNC
Primary source
HGNC:1033
See related
Ensembl:ENSG00000176697; HPRD:00214; MIM:113505; Vega:OTTHUMG00000178797
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ANON2; BULN2
Summary
The protein encoded by this gene is a member of the nerve growth factor family. It is induced by cortical neurons, and is necessary for survival of striatal neurons in the brain. Expression of this gene is reduced in both Alzheimer's and Huntington disease patients. This gene may play a role in the regulation of stress response and in the biology of mood disorders. Multiple transcript variants encoding distinct isoforms have been described for this gene. [provided by RefSeq, Jan 2009]
See BDNF in Epigenomics, MapViewer
Location:
11p13
Exon count :
11
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 11 NC_000011.10 (27654893..27722058, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (27676440..27743605, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene BDNF antisense RNA Neighboring gene ribosomal protein S25 pseudogene 1 Neighboring gene long intergenic non-protein coding RNA 678 Neighboring gene chromobox homolog 3 pseudogene 1 Neighboring gene heat shock protein 90kDa alpha (cytosolic), class A member 2

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Associated conditions

Description Tests
Bulimia nervosa 1
MedGen: C1843776 OMIM: 607499 GeneReviews: Not available
Compare labs
Bulimia nervosa 2
MedGen: C1853220 OMIM: 610269 GeneReviews: Not available
Compare labs
Congenital central hypoventilation Compare labs
Obsessive-compulsive disorder
MedGen: C1834037 OMIM: 164230 GeneReviews: Not available
Compare labs

NHGRI GWAS Catalog

Description
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index.
NHGRI GWA Catalog
Common variants at CDKAL1 and KLF9 are associated with body mass index in east Asian populations.
NHGRI GWA Catalog
Genome wide association study identifies KCNMA1 contributing to human obesity.
NHGRI GWA Catalog
Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity.
NHGRI GWA Catalog
Genome-wide meta-analyses identify multiple loci associated with smoking behavior.
NHGRI GWA Catalog
Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture.
NHGRI GWA Catalog

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Co-exposure of human fetal neurons to brain-derived neurotrophic factor (BDNF) and HIV-1 gp120 leads to a dose-dependent increase in BDNF-induced somatostatin (SRIF) production PubMed
Tat, p14 tat HIV-1 Tat increases proapoptotic proBDNF and decreases the mature BDNF protein in hippocampal neurons PubMed

Go to the HIV-1, Human Protein Interaction Database

  • Alcoholism, organism-specific biosystem (from KEGG)
    Alcoholism, organism-specific biosystemAlcoholism, also called dependence on alcohol (ethanol), is a chronic relapsing disorder that is progressive and has serious detrimental health outcomes. As one of the primary mediators of the reward...
  • Alcoholism, conserved biosystem (from KEGG)
    Alcoholism, conserved biosystemAlcoholism, also called dependence on alcohol (ethanol), is a chronic relapsing disorder that is progressive and has serious detrimental health outcomes. As one of the primary mediators of the reward...
  • BDNF signaling pathway, organism-specific biosystem (from WikiPathways)
    BDNF signaling pathway, organism-specific biosystemBrain-derived neurotrophic factor (BDNF) is a neurotrophin essential for growth, differentiation, plasticity, and survival of neurons. BDNF is also required for processes such as energy metabolism, b...
  • Cocaine addiction, organism-specific biosystem (from KEGG)
    Cocaine addiction, organism-specific biosystemDrug addiction is a chronic, relapsing disorder in which compulsive drug-seeking and drug-taking behavior persists despite serious negative consequences.There is strong evidence that the dopaminergic...
  • Cocaine addiction, conserved biosystem (from KEGG)
    Cocaine addiction, conserved biosystemDrug addiction is a chronic, relapsing disorder in which compulsive drug-seeking and drug-taking behavior persists despite serious negative consequences.There is strong evidence that the dopaminergic...
  • FSH signaling pathway, organism-specific biosystem (from WikiPathways)
    FSH signaling pathway, organism-specific biosystemThe Follicle Stimulating Hormone (FSH) is an anterior pituitary gonadotropin belonging to the family of glycoprotein hormones that includes thyroid stimulating hormone (TSH), Leutinizing Hormone (LH)...
  • Huntington's disease, organism-specific biosystem (from KEGG)
    Huntington's disease, organism-specific biosystemHuntington disease (HD) is an autosomal-dominant neurodegenerative disorder that primarily affects medium spiny striatal neurons (MSN). The symptoms are choreiform, involuntary movements, personality...
  • Huntington's disease, conserved biosystem (from KEGG)
    Huntington's disease, conserved biosystemHuntington disease (HD) is an autosomal-dominant neurodegenerative disorder that primarily affects medium spiny striatal neurons (MSN). The symptoms are choreiform, involuntary movements, personality...
  • Integrated Pancreatic Cancer Pathway, organism-specific biosystem (from WikiPathways)
    Integrated Pancreatic Cancer Pathway, organism-specific biosystemAn integrated pathway model which displays the protein-protein interactions (PPIs) among the relevant proteins for pancreatic cancer. This pathway is a collection of different mechanistic protein pat...
  • MAPK signaling pathway, organism-specific biosystem (from WikiPathways)
    MAPK signaling pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
  • MAPK signaling pathway, organism-specific biosystem (from KEGG)
    MAPK signaling pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
  • MAPK signaling pathway, conserved biosystem (from KEGG)
    MAPK signaling pathway, conserved biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
  • Neurotrophic factor-mediated Trk receptor signaling, organism-specific biosystem (from Pathway Interaction Database)
    Neurotrophic factor-mediated Trk receptor signaling, organism-specific biosystem
    Neurotrophic factor-mediated Trk receptor signaling
  • Neurotrophin signaling pathway, organism-specific biosystem (from KEGG)
    Neurotrophin signaling pathway, organism-specific biosystemNeurotrophins are a family of trophic factors involved in differentiation and survival of neural cells. The neurotrophin family consists of nerve growth factor (NGF), brain derived neurotrophic facto...
  • Neurotrophin signaling pathway, conserved biosystem (from KEGG)
    Neurotrophin signaling pathway, conserved biosystemNeurotrophins are a family of trophic factors involved in differentiation and survival of neural cells. The neurotrophin family consists of nerve growth factor (NGF), brain derived neurotrophic facto...
  • SIDS Susceptibility Pathways, organism-specific biosystem (from WikiPathways)
    SIDS Susceptibility Pathways, organism-specific biosystemIn this model, we provide an integrated view of Sudden Infant Death Syndrome (SIDS) at the level of implicated tissues, signaling networks and genetics. The purpose of this model is to serve as an ov...
  • Spinal Cord Injury, organism-specific biosystem (from WikiPathways)
    Spinal Cord Injury, organism-specific biosystemThis pathway provides an overview of cell types, therapeutic targets, drugs, new proposed targets and pathways implicated in spinal cord injury. Spinal cord injury is a complex multistep process that...
  • p75(NTR)-mediated signaling, organism-specific biosystem (from Pathway Interaction Database)
    p75(NTR)-mediated signaling, organism-specific biosystem
    p75(NTR)-mediated signaling
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
growth factor activity IEA
Inferred from Electronic Annotation
more info
 
neurotrophin TRKB receptor binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
axon guidance IEA
Inferred from Electronic Annotation
more info
 
axon target recognition IEA
Inferred from Electronic Annotation
more info
 
behavioral fear response IEA
Inferred from Electronic Annotation
more info
 
chronic inflammatory response IEA
Inferred from Electronic Annotation
more info
 
dendrite development IEA
Inferred from Electronic Annotation
more info
 
feeding behavior IEA
Inferred from Electronic Annotation
more info
 
glutamate secretion IEA
Inferred from Electronic Annotation
more info
 
inner ear development IEA
Inferred from Electronic Annotation
more info
 
learning or memory IEA
Inferred from Electronic Annotation
more info
 
mechanoreceptor differentiation IEA
Inferred from Electronic Annotation
more info
 
mitochondrial electron transport, NADH to ubiquinone IEA
Inferred from Electronic Annotation
more info
 
negative regulation of neuroblast proliferation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of neuron apoptotic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of striated muscle tissue development IEA
Inferred from Electronic Annotation
more info
 
nerve development IEA
Inferred from Electronic Annotation
more info
 
nervous system development TAS
Traceable Author Statement
more info
PubMed 
neuron recognition IEA
Inferred from Electronic Annotation
more info
 
positive regulation of long-term neuronal synaptic plasticity IEA
Inferred from Electronic Annotation
more info
 
positive regulation of neuron differentiation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of synapse assembly IDA
Inferred from Direct Assay
more info
PubMed 
regulation of excitatory postsynaptic membrane potential IEA
Inferred from Electronic Annotation
more info
 
regulation of metabolic process IEA
Inferred from Electronic Annotation
more info
 
regulation of retinal cell programmed cell death IEA
Inferred from Electronic Annotation
more info
 
regulation of short-term neuronal synaptic plasticity IEA
Inferred from Electronic Annotation
more info
 
response to anesthetic IEA
Inferred from Electronic Annotation
more info
 
response to fluoxetine IEA
Inferred from Electronic Annotation
more info
 
response to hormone IEA
Inferred from Electronic Annotation
more info
 
response to hyperoxia IEA
Inferred from Electronic Annotation
more info
 
response to hypoxia IEA
Inferred from Electronic Annotation
more info
 
response to vitamin A IEA
Inferred from Electronic Annotation
more info
 
ureteric bud development IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
extracellular region IEA
Inferred from Electronic Annotation
more info
 
perinuclear region of cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
synaptic vesicle IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
brain-derived neurotrophic factor
Names
brain-derived neurotrophic factor
abrineurin
neurotrophin

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_011794.1 

    Range
    5001..72164
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001143805.1NP_001137277.1  brain-derived neurotrophic factor isoform a preproprotein

    See proteins identical to NP_001137277.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7), also known as IIa or BDNF2A, differs in the 5' UTR and represents use of an alternate promoter compared to variant 1. Variants 1, 2, 4, 5, and 7-16 encode the same isoform (a).
    Source sequence(s)
    EF674517
    Consensus CDS
    CCDS7866.1
    UniProtKB/Swiss-Prot
    P23560
    Related
    ENSP00000432035, OTTHUMP00000232006, ENST00000525950, OTTHUMT00000388086
    Conserved Domains (1) summary
    pfam00243
    Location:130247
    Blast Score: 542
    NGF; Nerve growth factor family
  2. NM_001143806.1NP_001137278.1  brain-derived neurotrophic factor isoform a preproprotein

    See proteins identical to NP_001137278.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8), also known as IIb or BDNF2B, differs in the 5' UTR and represents use of an alternate promoter compared to variant 1. Variants 1, 2, 4, 5, and 7-16 encode the same isoform (a).
    Source sequence(s)
    EF674518
    Consensus CDS
    CCDS7866.1
    UniProtKB/Swiss-Prot
    P23560
    Related
    ENSP00000379302, OTTHUMP00000232022, ENST00000395978, OTTHUMT00000388105
    Conserved Domains (1) summary
    pfam00243
    Location:130247
    Blast Score: 542
    NGF; Nerve growth factor family
  3. NM_001143807.1NP_001137279.1  brain-derived neurotrophic factor isoform a preproprotein

    See proteins identical to NP_001137279.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9), also known as III or BDNF3, differs in the 5' UTR and represents use of an alternate promoter compared to variant 1. Variants 1, 2, 4, 5, and 7-16 encode the same isoform (a).
    Source sequence(s)
    EF674520
    Consensus CDS
    CCDS7866.1
    UniProtKB/Swiss-Prot
    P23560
    Related
    ENSP00000435805, OTTHUMP00000232021, ENST00000532997, OTTHUMT00000388104
    Conserved Domains (1) summary
    pfam00243
    Location:130247
    Blast Score: 542
    NGF; Nerve growth factor family
  4. NM_001143808.1NP_001137280.1  brain-derived neurotrophic factor isoform a preproprotein

    See proteins identical to NP_001137280.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10), also known as Va, differs in the 5' UTR and represents use of an alternate promoter compared to variant 1. Variants 1, 2, 4, 5, and 7-16 encode the same isoform (a).
    Source sequence(s)
    EF689011
    Consensus CDS
    CCDS7866.1
    UniProtKB/Swiss-Prot
    P23560
    Related
    ENSP00000379307, OTTHUMP00000232018, ENST00000395983, OTTHUMT00000388101
    Conserved Domains (1) summary
    pfam00243
    Location:130247
    Blast Score: 542
    NGF; Nerve growth factor family
  5. NM_001143809.1NP_001137281.1  brain-derived neurotrophic factor isoform d preproprotein

    See proteins identical to NP_001137281.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (17), also known as Vb, represents use of an alternate promoter and differs in the 5' UTR and 5' coding region, compared to variant 1. The resulting isoform (d) contains a longer N-terminus compared to isoform a.
    Source sequence(s)
    EF689012
    UniProtKB/Swiss-Prot
    P23560
    Conserved Domains (1) summary
    pfam00243
    Location:159276
    Blast Score: 536
    NGF; Nerve growth factor family
  6. NM_001143810.1NP_001137282.1  brain-derived neurotrophic factor isoform e

    See proteins identical to NP_001137282.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (18), also known as V-VIII, represents use of an alternate promoter and differs in the 5' UTR and 5' coding region, compared to variant 1. The resulting isoform (e) contains a longer N-terminus compared to isoform a.
    Source sequence(s)
    EF689019
    Consensus CDS
    CCDS44558.1
    UniProtKB/Swiss-Prot
    P23560
    Related
    ENSP00000414303, OTTHUMP00000232019, ENST00000438929, OTTHUMT00000388102
    Conserved Domains (1) summary
    pfam00243
    Location:212329
    Blast Score: 543
    NGF; Nerve growth factor family
  7. NM_001143811.1NP_001137283.1  brain-derived neurotrophic factor isoform a preproprotein

    See proteins identical to NP_001137283.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (11), also known as V-VIII-VIIIh, differs in the 5' UTR and represents use of an alternate promoter compared to variant 1. Variants 1, 2, 4, 5, and 7-16 encode the same isoform (a).
    Source sequence(s)
    EF689020
    Consensus CDS
    CCDS7866.1
    UniProtKB/Swiss-Prot
    P23560
    Related
    ENSP00000389564, ENST00000420794
    Conserved Domains (1) summary
    pfam00243
    Location:130247
    Blast Score: 542
    NGF; Nerve growth factor family
  8. NM_001143812.1NP_001137284.1  brain-derived neurotrophic factor isoform a preproprotein

    See proteins identical to NP_001137284.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (12), also known as Vh, differs in the 5' UTR and represents use of an alternate promoter compared to variant 1. Variants 1, 2, 4, 5, and 7-16 encode the same isoform (a).
    Source sequence(s)
    CX751420, EF689013
    Consensus CDS
    CCDS7866.1
    UniProtKB/Swiss-Prot
    P23560
    Related
    ENSP00000435564, OTTHUMP00000232016, ENST00000530861, OTTHUMT00000388099
    Conserved Domains (1) summary
    pfam00243
    Location:130247
    Blast Score: 542
    NGF; Nerve growth factor family
  9. NM_001143813.1NP_001137285.1  brain-derived neurotrophic factor isoform a preproprotein

    See proteins identical to NP_001137285.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (13), also known as VIa, differs in the 5' UTR and represents use of an alternate promoter compared to variant 1. Variants 1, 2, 4, 5, and 7-16 encode the same isoform (a).
    Source sequence(s)
    EF689014
    Consensus CDS
    CCDS7866.1
    UniProtKB/Swiss-Prot
    P23560
    Related
    ENSP00000432376, OTTHUMP00000232015, ENST00000533246, OTTHUMT00000388098
    Conserved Domains (1) summary
    pfam00243
    Location:130247
    Blast Score: 542
    NGF; Nerve growth factor family
  10. NM_001143814.1NP_001137286.1  brain-derived neurotrophic factor isoform a preproprotein

    See proteins identical to NP_001137286.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (14), also known as VIb-IXbd, differs in the 5' UTR and represents use of an alternate promoter compared to variant 1. Variants 1, 2, 4, 5, and 7-16 encode the same isoform (a).
    Source sequence(s)
    EF689016
    Consensus CDS
    CCDS7866.1
    UniProtKB/Swiss-Prot
    P23560
    Related
    ENSP00000400502, OTTHUMP00000232014, ENST00000418212, OTTHUMT00000388097
    Conserved Domains (1) summary
    pfam00243
    Location:130247
    Blast Score: 542
    NGF; Nerve growth factor family
  11. NM_001143816.1NP_001137288.1  brain-derived neurotrophic factor isoform a preproprotein

    See proteins identical to NP_001137288.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (16), also known as IXabd, differs in the 5' UTR compared to variant 1. Variants 1, 2, 4, 5, and 7-16 encode the same isoform (a).
    Source sequence(s)
    EF689010
    Consensus CDS
    CCDS7866.1
    UniProtKB/Swiss-Prot
    P23560
    Related
    ENSP00000389345, OTTHUMP00000232039, ENST00000439476, OTTHUMT00000388134
    Conserved Domains (1) summary
    pfam00243
    Location:130247
    Blast Score: 542
    NGF; Nerve growth factor family
  12. NM_001709.4NP_001700.2  brain-derived neurotrophic factor isoform a preproprotein

    See proteins identical to NP_001700.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4), also known as VIb or BDNF5, differs in the 5' UTR and represents use of an alternate promoter compared to variant 1. Variants 1, 2, 4, 5, and 7-16 encode the same isoform (a).
    Source sequence(s)
    EF689015
    Consensus CDS
    CCDS7866.1
    UniProtKB/Swiss-Prot
    P23560
    Related
    ENSP00000349084, OTTHUMP00000232013, ENST00000356660, OTTHUMT00000388096
    Conserved Domains (1) summary
    pfam00243
    Location:130247
    Blast Score: 542
    NGF; Nerve growth factor family
  13. NM_170731.4NP_733927.1  brain-derived neurotrophic factor isoform b preproprotein

    See proteins identical to NP_733927.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3), also known as I, BDNF1, or 1-5, represents use of an alternate promoter and differs in the 5' UTR and 5' coding region, compared to variant 1. The resulting isoform (b) contains a longer N-terminus compared to isoform a.
    Source sequence(s)
    EF689021
    Consensus CDS
    CCDS7865.1
    UniProtKB/Swiss-Prot
    P23560
    Related
    ENSP00000320002, OTTHUMP00000232043, ENST00000314915, OTTHUMT00000388138
    Conserved Domains (1) summary
    pfam00243
    Location:138255
    Blast Score: 542
    NGF; Nerve growth factor family
  14. NM_170732.4NP_733928.1  brain-derived neurotrophic factor isoform a preproprotein

    See proteins identical to NP_733928.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2), also known as IIc, BDNF2C, or 2-5, differs in the 5' UTR and represents use of an alternate promoter compared to variant 1. Variants 1, 2, 4, 5, and 7-16 encode the same isoform (a).
    Source sequence(s)
    EF674519
    Consensus CDS
    CCDS7866.1
    UniProtKB/Swiss-Prot
    P23560
    Related
    ENSP00000379305, OTTHUMP00000232005, ENST00000395981, OTTHUMT00000388085
    Conserved Domains (1) summary
    pfam00243
    Location:130247
    Blast Score: 542
    NGF; Nerve growth factor family
  15. NM_170733.3NP_733929.1  brain-derived neurotrophic factor isoform a preproprotein

    See proteins identical to NP_733929.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5), also known as IV, BDNF4, or 3-5, differs in the 5' UTR and represents use of an alternate promoter compared to variant 1. Variants 1, 2, 4, 5, and 7-16 encode the same isoform (a).
    Source sequence(s)
    EF674521
    Consensus CDS
    CCDS7866.1
    UniProtKB/Swiss-Prot
    P23560
    Related
    ENSP00000379304, ENST00000395980
    Conserved Domains (1) summary
    pfam00243
    Location:130247
    Blast Score: 542
    NGF; Nerve growth factor family
  16. NM_170734.3NP_733930.1  brain-derived neurotrophic factor isoform c preproprotein

    See proteins identical to NP_733930.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6), also known as VIIb, BDNF6B, or 4I-5, represents use of an alternate promoter and differs in the 5' UTR and 5' coding region, compared to variant 1. The resulting isoform (c) contains a longer N-terminus compared to isoform a.
    Source sequence(s)
    EF689018
    Consensus CDS
    CCDS41628.1
    UniProtKB/Swiss-Prot
    P23560
    Related
    ENSP00000379309, OTTHUMP00000232041, ENST00000395986, OTTHUMT00000388136
    Conserved Domains (1) summary
    pfam00243
    Location:145262
    Blast Score: 540
    NGF; Nerve growth factor family
  17. NM_170735.5NP_733931.1  brain-derived neurotrophic factor isoform a preproprotein

    See proteins identical to NP_733931.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1), also known as IX, represents the longest transcript. Variants 1, 2, 4, 5, and 7-16 encode the same isoform (a).
    Source sequence(s)
    EF689009
    Consensus CDS
    CCDS7866.1
    UniProtKB/Swiss-Prot
    P23560
    Related
    ENSP00000437138, OTTHUMP00000232040, ENST00000525528, OTTHUMT00000388135
    Conserved Domains (1) summary
    pfam00243
    Location:130247
    Blast Score: 542
    NGF; Nerve growth factor family

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000011.10 

    Range
    27654893..27722058
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

  1. AC_000143.1 

    Range
    27374586..27441772
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018922.2 

    Range
    27675184..27742527
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001143815.1: Suppressed sequence

    Description
    NM_001143815.1: This RefSeq was temporarily suppressed because currently there is not sufficient data to support this transcript, which contains non-consensus splice sites in the 5' UTR.

Supplemental Content

Recent activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...