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    ZFP36 ZFP36 ring finger protein [ Homo sapiens (human) ]

    Gene ID: 7538, updated on 23-Sep-2016
    Official Symbol
    ZFP36provided by HGNC
    Official Full Name
    ZFP36 ring finger proteinprovided by HGNC
    Primary source
    HGNC:HGNC:12862
    See related
    Ensembl:ENSG00000128016 HPRD:01835; MIM:190700; Vega:OTTHUMG00000182970
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TTP; G0S24; GOS24; TIS11; NUP475; zfp-36; RNF162A
    Orthologs
    Location:
    19q13.1
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 19 NC_000019.10 (39406847..39409412)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (39897487..39900052)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene sterile alpha motif domain containing 4B Neighboring gene PAF1 homolog, Paf1/RNA polymerase II complex component Neighboring gene mediator complex subunit 29 Neighboring gene transfer RNA-Ile (TAT) 1-1 Neighboring gene microRNA 4530

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat Primary human Muller glia cells treated with both HIV-1 clade B and clade C Tat upregulate the expression of tristetraprolin PubMed

    Go to the HIV-1, Human Interaction Database

    • ErbB1 downstream signaling, organism-specific biosystem (from Pathway Interaction Database)
      ErbB1 downstream signaling, organism-specific biosystem
      ErbB1 downstream signaling
    • Gene Expression, organism-specific biosystem (from REACTOME)
      Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
    • HTLV-I infection, organism-specific biosystem (from KEGG)
      HTLV-I infection, organism-specific biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
    • HTLV-I infection, conserved biosystem (from KEGG)
      HTLV-I infection, conserved biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
    • Regulation of mRNA stability by proteins that bind AU-rich elements, organism-specific biosystem (from REACTOME)
      Regulation of mRNA stability by proteins that bind AU-rich elements, organism-specific biosystemRNA elements rich in adenine and uracil residues (AU-rich elements) bind specific proteins which either target the RNA for degradation or, more rarely, stabilize the RNA. The activity of the AU-eleme...
    • Spinal Cord Injury, organism-specific biosystem (from WikiPathways)
      Spinal Cord Injury, organism-specific biosystemThis pathway provides an overview of cell types, therapeutic targets, drugs, new proposed targets and pathways implicated in spinal cord injury. Spinal cord injury is a complex multistep process that...
    • Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA, organism-specific biosystem (from REACTOME)
      Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA, organism-specific biosystemTristetraproline (TTP) binds RNAs that contain AU-rich elements and recruits enzymes that degrade RNA. TTP interacts with the exosome (3' to 5' exonuclease), XRN1 (5' to 3' exonuclease), and the deca...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    14-3-3 protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    AU-rich element binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    AU-rich element binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    C-C chemokine binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    RNA polymerase binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enzyme binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    heat shock protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mRNA 3'-UTR AU-rich region binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mRNA 3'-UTR binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    mRNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    poly(A) RNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    single-stranded RNA binding TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    3'-UTR-mediated mRNA destabilization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    3'-UTR-mediated mRNA destabilization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    3'-UTR-mediated mRNA destabilization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    3'-UTR-mediated mRNA stabilization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    MAPK cascade IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    MAPK cascade ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cellular response to epidermal growth factor stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to fibroblast growth factor stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to glucocorticoid stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to granulocyte macrophage colony-stimulating factor stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to lipopolysaccharide IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to lipopolysaccharide IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cellular response to tumor necrosis factor IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mRNA catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mRNA transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    miRNA mediated inhibition of translation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of erythrocyte differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of interleukin-2 biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of polynucleotide adenylyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of transcription from RNA polymerase II promoter IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of viral transcription IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nuclear-transcribed mRNA catabolic process, deadenylation-independent decay IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nuclear-transcribed mRNA poly(A) tail shortening IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    p38MAPK cascade ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of deadenylation-independent decapping of nuclear-transcribed mRNA IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of fat cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of gene silencing by miRNA IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of intracellular mRNA localization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of nuclear-transcribed mRNA poly(A) tail shortening IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of keratinocyte apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of keratinocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of keratinocyte proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of mRNA stability IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of mRNA stability IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of mRNA stability TAS
    Traceable Author Statement
    more info
     
    regulation of tumor necrosis factor production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    response to starvation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    response to wounding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    response to wounding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    colocalizes_with CCR4-NOT complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    colocalizes_with Dcp1-Dcp2 complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    colocalizes_with RISC-loading complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasmic mRNA processing body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasmic stress granule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol TAS
    Traceable Author Statement
    more info
     
    NOT colocalizes_with exosome (RNase complex) IDA
    Inferred from Direct Assay
    more info
    PubMed 
    intracellular ribonucleoprotein complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ribonucleoprotein complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    tristetraprolin
    Names
    G0/G1 switch regulatory protein 24
    growth factor-inducible nuclear protein NUP475
    tristetraproline
    zinc finger protein 36 homolog
    zinc finger protein 36, C3H type, homolog
    zinc finger protein, C3H type, 36 homolog

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_003407.3NP_003398.2  tristetraprolin

      See identical proteins and their annotated locations for NP_003398.2

      Status: VALIDATED

      Source sequence(s)
      BM055332, M92843
      Consensus CDS
      CCDS12534.2
      UniProtKB/Swiss-Prot
      P26651
      UniProtKB/TrEMBL
      M0QY76
      Related
      ENSP00000469647, OTTHUMP00000270580, ENST00000597629, OTTHUMT00000464495
      Conserved Domains (1) summary
      pfam00642
      Location:110135
      zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p7 Primary Assembly

      Range
      39406847..39409412
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.1

    Genomic

    1. NC_018930.2 Alternate CHM1_1.1

      Range
      39898190..39900755
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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