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    MMP9 matrix metallopeptidase 9 [ Homo sapiens (human) ]

    Gene ID: 4318, updated on 22-Aug-2016
    Official Symbol
    MMP9provided by HGNC
    Official Full Name
    matrix metallopeptidase 9provided by HGNC
    Primary source
    HGNC:HGNC:7176
    See related
    Ensembl:ENSG00000100985 HPRD:00387; MIM:120361; Vega:OTTHUMG00000033044
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GELB; CLG4B; MMP-9; MANDP2
    Summary
    Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The enzyme encoded by this gene degrades type IV and V collagens. Studies in rhesus monkeys suggest that the enzyme is involved in IL-8-induced mobilization of hematopoietic progenitor cells from bone marrow, and murine studies suggest a role in tumor-associated tissue remodeling. [provided by RefSeq, Jul 2008]
    Orthologs
    Location:
    20q13.12
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 20 NC_000020.11 (46008908..46016561)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (44637547..44645200)

    Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene zinc finger protein 335 Neighboring gene ferritin light chain pseudogene 1 Neighboring gene uncharacterized LOC105372632 Neighboring gene solute carrier family 12 member 5 Neighboring gene nuclear receptor coactivator 5

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Associated conditions

    Description Tests
    Metaphyseal anadysplasia 2
    MedGen: C2751322 OMIM: 613073 GeneReviews: Not available
    Compare labs

    NHGRI GWAS Catalog

    Description
    Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
    NHGRI GWA Catalog

    Replication interactions

    Interaction Pubs
    Knockdown of matrix metallopeptidase 9 (gelatinase B; 92kDa gelatinase; 92kDa type IV collagenase; MMP9) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV-1 gp120-mediated binding of human mannose receptor induces MMP-9 expression in vaginal epithelial cells PubMed
    env Inhibition of NRF2 by siRNA results in increased NOX2, NFkappaB (p65/p50), TNF-alpha, and MMP-9 proteins in astrocytes exposed to HIV-1 gp120 PubMed
    env Matrix metalloproteinases MMP2 and MMP9 participate in the maturation process of cleavage and activation of IL-1beta based on the intracerebroventricular injection of the HIV-1 envelope glycoprotein gp120 PubMed
    env Concomitant incubation with gp120 and methamphetamine stimulates LPS-induced MMP-9 expression and biological activity in monocyte-derived macrophages PubMed
    env T- and M-tropic HIV-1 gp120 proteins are able to induce the secretion of matrix metalloproteinase 9 (MMP-9) by T cells or glioma cells; MMP-9 is an extracellular metalloproteinase present in cerebrospinal fluid of patients with HIV-1 PubMed
    Nef nef Overexpression of HIV-1 Nef and ALK effect gelatinase activation in astrocytic glioma cells PubMed
    nef MMP-9 activity in the cerebrospinal fluid (CSF) samples from rats is induced by injecting the rats intracisternally with recombinant HIV-1 Nef protein, but not after injection of heat-treated Nef, HIV-1 gp120, HIV-1 gp160 or PBS PubMed
    Tat tat The basic domain (49RKKRRQRRR57) of HIV-1 Tat is essential for enhancing the FGF-induced activation of ERK, Rho-A, and MLC2 and upregulates the expression of MMP-9 in human podocytes PubMed
    tat HIV-1 Tat protein increases the permeability of primary human brain micro vascular endothelial cells by both inhibiting occludin expression and cleaving occludin via matrix metalloproteinase-9 PubMed
    tat HIV-1 Tat-induced MAPK (ERK, JNK, and p38) activation is required for MMP-9 expression in human astrocytes PubMed
    tat HIV-1 Tat-mediated upregulation of MMP-9 in human astrocytes results from NF-kappaB activation pathway PubMed
    tat HIV-1 Tat upregulates the expression of MMP-9 in monocytes in an IL-1beta, TNF-alpha, and tyrosine phosphatase dependent manner PubMed

    Go to the HIV-1, Human Interaction Database

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    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    collagen binding TAS
    Traceable Author Statement
    more info
    PubMed 
    endopeptidase activity EXP
    Inferred from Experiment
    more info
    PubMed 
    endopeptidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    metalloendopeptidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    metalloendopeptidase activity TAS
    Traceable Author Statement
    more info
     
    metallopeptidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    serine-type endopeptidase activity EXP
    Inferred from Experiment
    more info
    PubMed 
    serine-type endopeptidase activity TAS
    Traceable Author Statement
    more info
     
    zinc ion binding TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    collagen catabolic process TAS
    Traceable Author Statement
    more info
     
    embryo implantation IEA
    Inferred from Electronic Annotation
    more info
     
    endodermal cell differentiation IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    ephrin receptor signaling pathway TAS
    Traceable Author Statement
    more info
     
    extracellular matrix disassembly TAS
    Traceable Author Statement
    more info
     
    leukocyte migration IEA
    Inferred from Electronic Annotation
    more info
     
    macrophage differentiation TAS
    Traceable Author Statement
    more info
    PubMed 
    negative regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of cation channel activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of intrinsic apoptotic signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    ossification IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of epidermal growth factor receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of keratinocyte migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of protein phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of receptor binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of release of cytochrome c from mitochondria IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of vascular smooth muscle cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    proteolysis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    skeletal system development IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    extracellular exosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular region TAS
    Traceable Author Statement
    more info
     
    extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    proteinaceous extracellular matrix IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    matrix metalloproteinase-9
    Names
    macrophage gelatinase
    matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)
    matrix metalloproteinase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)
    type V collagenase
    NP_004985.2

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_011468.1 RefSeqGene

      Range
      5001..12654
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_004994.2NP_004985.2  matrix metalloproteinase-9 preproprotein

      See identical proteins and their annotated locations for NP_004985.2

      Status: REVIEWED

      Source sequence(s)
      AW468235, BC006093, CN288579, J05070
      Consensus CDS
      CCDS13390.1
      UniProtKB/Swiss-Prot
      P14780
      Related
      ENSP00000361405, OTTHUMP00000031674, ENST00000372330, OTTHUMT00000080337
      Conserved Domains (6) summary
      smart00059
      Location:281329
      FN2; Fibronectin type 2 domain
      cd00094
      Location:514704
      HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
      cd04278
      Location:115444
      ZnMc_MMP; Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate ...
      pfam00040
      Location:347388
      fn2; Fibronectin type II domain
      pfam00413
      Location:115444
      Peptidase_M10; Matrixin
      pfam04886
      Location:472506
      PT; PT repeat

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000020.11 Reference GRCh38.p7 Primary Assembly

      Range
      46008908..46016561
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.1

    Genomic

    1. NC_018931.2 Alternate CHM1_1.1

      Range
      44540180..44547844
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)