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ANXA7 annexin A7 [ Homo sapiens (human) ]

Gene ID: 310, updated on 7-Dec-2014
Official Symbol
ANXA7provided by HGNC
Official Full Name
annexin A7provided by HGNC
Primary source
HGNC:HGNC:545
Locus tag
RP11-537A6.8
See related
Ensembl:ENSG00000138279; HPRD:01720; MIM:186360; Vega:OTTHUMG00000018463
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SNX; ANX7; SYNEXIN
Summary
Annexin VII is a member of the annexin family of calcium-dependent phospholipid binding proteins.The Annexin VII gene contains 14 exons and spans approximately 34 kb of DNA. An alternatively spliced cassette exon results in two mRNA transcripts of 2.0 and 2.4 kb which are predicted to generate two protein isoforms differing in their N-terminal domain. The alternative splicing event is tissue specific and the mRNA containing the cassette exon is prevalent in brain, heart and skeletal muscle. The transcripts also differ in their 3'-non coding regions by the use of two alternative poly(A) signals. Annexin VII encodes a protein with a molecular weight of approximately 51 kDa with a unique, highly hydrophobic N-terminal domain of 167 amino acids and a conserved C-terminal region of 299 amino acids. The latter domain is composed of alternating hydrophobic and hydrophilic segments. Structural analysis of the protein suggests that Annexin VII is a membrane binding protein with diverse properties, including voltage-sensitive calcium channel activity, ion selectivity and membrane fusion. [provided by RefSeq, Jul 2008]
See ANXA7 in Epigenomics, MapViewer
Location:
10q22.2
Exon count:
14
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 10 NC_000010.11 (73375431..73414083, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (75135189..75173841, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene DNAJC9 antisense RNA 1 Neighboring gene uncharacterized LOC101929112 Neighboring gene DnaJ (Hsp40) homolog, subfamily C, member 9 Neighboring gene mitochondrial ribosomal protein S16 Neighboring gene cilia and flagella associated protein 70 Neighboring gene ribosomal protein L26 pseudogene 6 Neighboring gene MSS51 mitochondrial translational activator

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
calcium-dependent phospholipid binding IEA
Inferred from Electronic Annotation
more info
 
calcium-dependent protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
integrin binding IPI
Inferred from Physical Interaction
more info
PubMed 
poly(A) RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
autophagy IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell proliferation IEA
Inferred from Electronic Annotation
more info
 
cellular calcium ion homeostasis IEA
Inferred from Electronic Annotation
more info
 
cellular water homeostasis IEA
Inferred from Electronic Annotation
more info
 
epithelial cell differentiation IEP
Inferred from Expression Pattern
more info
PubMed 
hemostasis IEA
Inferred from Electronic Annotation
more info
 
membrane fusion IEA
Inferred from Electronic Annotation
more info
 
negative regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of cell shape IEA
Inferred from Electronic Annotation
more info
 
response to calcium ion IEA
Inferred from Electronic Annotation
more info
 
response to organic cyclic compound IEA
Inferred from Electronic Annotation
more info
 
response to salt stress IEA
Inferred from Electronic Annotation
more info
 
social behavior IEP
Inferred from Expression Pattern
more info
PubMed 
Component Evidence Code Pubs
colocalizes_with chromaffin granule membrane IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IEA
Inferred from Electronic Annotation
more info
 
endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
PubMed 
extracellular vesicular exosome IDA
Inferred from Direct Assay
more info
PubMed 
membrane IDA
Inferred from Direct Assay
more info
PubMed 
nuclear envelope IEA
Inferred from Electronic Annotation
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
annexin A7
Names
annexin A7
annexin-7
annexin VII

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001156.3NP_001147.1  annexin A7 isoform 1

    See proteins identical to NP_001147.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) lacks an alternate in-frame exon, compared to variant 2, resulting in a shorter protein (isoform 1) that lacks an internal segment, compared to isoform 2.
    Source sequence(s)
    AL512656, AW518993, DC367313, J04543
    Consensus CDS
    CCDS7325.1
    UniProtKB/Swiss-Prot
    P20073
    Related
    ENSP00000362012, OTTHUMP00000019812, ENST00000372921, OTTHUMT00000048646
    Conserved Domains (2) summary
    pfam00191
    Location:167232
    Annexin; Annexin
    pfam11029
    Location:84165
    DAZAP2; DAZ associated protein 2 (DAZAP2)
  2. NM_004034.2NP_004025.1  annexin A7 isoform 2

    See proteins identical to NP_004025.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) represents the longest transcript and encodes the longest isoform (2).
    Source sequence(s)
    AK312447, AL512656, AW518993, DC367313
    Consensus CDS
    CCDS7326.1
    UniProtKB/TrEMBL
    B2R657
    UniProtKB/Swiss-Prot
    P20073
    Related
    ENSP00000362010, OTTHUMP00000019813, ENST00000372919, OTTHUMT00000048647
    Conserved Domains (2) summary
    pfam00191
    Location:189254
    Annexin; Annexin
    pfam11029
    Location:84145
    DAZAP2; DAZ associated protein 2 (DAZAP2)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000010.11 

    Range
    73375431..73414083
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005269738.2XP_005269795.1  

    Conserved Domains (2) summary
    pfam00191
    Location:149214
    Annexin; Annexin
    pfam11029
    Location:44105
    DAZAP2; DAZ associated protein 2 (DAZAP2)
  2. XM_005269739.2XP_005269796.1  

    Conserved Domains (2) summary
    pfam00191
    Location:127192
    Annexin; Annexin
    pfam11029
    Location:44125
    DAZAP2; DAZ associated protein 2 (DAZAP2)

Alternate CHM1_1.1

Genomic

  1. NC_018921.2 

    Range
    75416936..75455602
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

  1. AC_000142.1 

    Range
    69129017..69167555
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)