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    BID BH3 interacting domain death agonist [ Homo sapiens (human) ]

    Gene ID: 637, updated on 8-Jun-2016
    Official Symbol
    BIDprovided by HGNC
    Official Full Name
    BH3 interacting domain death agonistprovided by HGNC
    Primary source
    HGNC:HGNC:1050
    See related
    Ensembl:ENSG00000015475 HPRD:03590; MIM:601997; Vega:OTTHUMG00000150087
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FP497
    Summary
    This gene encodes a death agonist that heterodimerizes with either agonist BAX or antagonist BCL2. The encoded protein is a member of the BCL-2 family of cell death regulators. It is a mediator of mitochondrial damage induced by caspase-8 (CASP8); CASP8 cleaves this encoded protein, and the COOH-terminal part translocates to mitochondria where it triggers cytochrome c release. Multiple alternatively spliced transcript variants have been found, but the full-length nature of some variants has not been defined. [provided by RefSeq, Jul 2008]
    Orthologs
    Location:
    22q11.1
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 22 NC_000022.11 (17734140..17774665, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (18216906..18257431, complement)

    Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene ATPase H+ transporting V1 subunit E1 Neighboring gene BCL2 like 13 Neighboring gene microRNA 3198-1 Neighboring gene long intergenic non-protein coding RNA 528 Neighboring gene microtubule associated monooxygenase, calponin and LIM domain containing 3 Neighboring gene microRNA 648

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env Caspase 8 proteolytic target protein Bid is cleaved and undergoes mitochondrial translocation in gp120-treated p53 expression neurons PubMed
    Tat tat HIV-1 Tat upregulates the expression of BH3 interacting domain death agonist (BID) in Jurkat cells PubMed
    tat FasL-induced cleavage of BID/p22 and BCL2 is inhibited in HIV-1 Tat101-expressing Jurkat cells PubMed
    Vpr vpr Inhibition of MEK1,2 impairs HIV-1 Vpr-induced BID cleavage PubMed
    vpr HIV-1 Vpr-induced caspase-8 activation causes cleavage of BID to tBID through ERK activation PubMed
    vpr Overexpression of BID is induced by HIV-1 Vpr in the transfected 293T cells PubMed
    retropepsin gag-pol HIV-1 protease directly cleaves and activates procaspase 8 in T cells which is associated with cleavage of BID, mitochondrial release of cytochrome c, activation of the downstream caspases 9 and 3, and cleavage of DFF and PARP PubMed

    Go to the HIV-1, Human Interaction Database

    • Activation and oligomerization of BAK protein, organism-specific biosystem (from REACTOME)
      Activation and oligomerization of BAK protein, organism-specific biosystemtBID binds to its mitochondrial partner BAK to release cytochrome c. Activated tBID results in an allosteric activation of BAK. This may induce its intramembranous oligomerization into a pore for cy...
    • Activation of BAD and translocation to mitochondria, organism-specific biosystem (from REACTOME)
      Activation of BAD and translocation to mitochondria, organism-specific biosystemThe switching on/off of its phosphorylation by growth/survival factors regulates BAD activity. BAD remains sequestered by 14-3-3 scaffold proteins after phosphorylation by Akt1. Calcineurin activate...
    • Activation of BH3-only proteins, organism-specific biosystem (from REACTOME)
      Activation of BH3-only proteins, organism-specific biosystemThe BH3-only members act as sentinels that selectively trigger apoptosis in response to developmental cues or stress-signals like DNA damages. Widely expressed mammalian BH3-only proteins are thought...
    • Activation, myristolyation of BID and translocation to mitochondria, organism-specific biosystem (from REACTOME)
      Activation, myristolyation of BID and translocation to mitochondria, organism-specific biosystemBID may promote cell death by activating BAX and BAK while inactivating anti-apoptotic proteins. The engagement of cell surface receptors activates the caspase-8, a heterodimer, that cleaves BID in i...
    • Activation, translocation and oligomerization of BAX, organism-specific biosystem (from REACTOME)
      Activation, translocation and oligomerization of BAX, organism-specific biosystemAs a result of binding to Bid, Bax oligomerizes and integrates in the outer mitochondrial membrane, triggering cytochrome c release. Bax mitochondrial membrane insertion triggered by Bid may represen...
    • Alzheimer's disease, organism-specific biosystem (from KEGG)
      Alzheimer's disease, organism-specific biosystemAlzheimer's disease (AD) is a chronic disorder that slowly destroys neurons and causes serious cognitive disability. AD is associated with senile plaques and neurofibrillary tangles (NFTs). Amyloid-b...
    • Alzheimer's disease, conserved biosystem (from KEGG)
      Alzheimer's disease, conserved biosystemAlzheimer's disease (AD) is a chronic disorder that slowly destroys neurons and causes serious cognitive disability. AD is associated with senile plaques and neurofibrillary tangles (NFTs). Amyloid-b...
    • Alzheimers Disease, organism-specific biosystem (from WikiPathways)
      Alzheimers Disease, organism-specific biosystemThis pathway displays current genes, proteolytic events and other processes associated with the progression of Alzheimer's disease. This pathway was adapted from KEGG on 10/7/2011. Note: mitochondria...
    • Amyotrophic lateral sclerosis (ALS), organism-specific biosystem (from WikiPathways)
      Amyotrophic lateral sclerosis (ALS), organism-specific biosystemAmyotrophic lateral sclerosis (ALS) is a progressive, lethal, degenerative disorder of motor neurons. The hallmark of this disease is the selective death of motor neurons in the brain and spinal cord...
    • Amyotrophic lateral sclerosis (ALS), organism-specific biosystem (from KEGG)
      Amyotrophic lateral sclerosis (ALS), organism-specific biosystemAmyotrophic lateral sclerosis (ALS) is a progressive, lethal, degenerative disorder of motor neurons. The hallmark of this disease is the selective death of motor neurons in the brain and spinal cord...
    • Amyotrophic lateral sclerosis (ALS), conserved biosystem (from KEGG)
      Amyotrophic lateral sclerosis (ALS), conserved biosystemAmyotrophic lateral sclerosis (ALS) is a progressive, lethal, degenerative disorder of motor neurons. The hallmark of this disease is the selective death of motor neurons in the brain and spinal cord...
    • Apoptosis, organism-specific biosystem (from WikiPathways)
      Apoptosis, organism-specific biosystemApoptosis is a distinct form of cell death that is functionally and morphologically different from necrosis. Nuclear chromatin condensation, cytoplasmic shrinking, dilated endoplasmic reticulum, and ...
    • Apoptosis, organism-specific biosystem (from KEGG)
      Apoptosis, organism-specific biosystemApoptosis is a genetically programmed process for the elimination of damaged or redundant cells by activation of caspases (aspartate-specific cysteine proteases). The onset of apoptosis is controlled...
    • Apoptosis, conserved biosystem (from KEGG)
      Apoptosis, conserved biosystemApoptosis is a genetically programmed process for the elimination of damaged or redundant cells by activation of caspases (aspartate-specific cysteine proteases). The onset of apoptosis is controlled...
    • Apoptosis, organism-specific biosystem (from REACTOME)
      Apoptosis, organism-specific biosystemApoptosis is a distinct form of cell death that is functionally and morphologically different from necrosis. Nuclear chromatin condensation, cytoplasmic shrinking, dilated endoplasmic reticulum, and ...
    • Apoptosis - multiple species, organism-specific biosystem (from KEGG)
      Apoptosis - multiple species, organism-specific biosystemApoptosis is an evolutionarily conserved process used by multicellular organisms to developmentally regulate cell number or to eliminate cells that are potentially detrimental to the organism. The ma...
    • Apoptosis - multiple species, conserved biosystem (from KEGG)
      Apoptosis - multiple species, conserved biosystemApoptosis is an evolutionarily conserved process used by multicellular organisms to developmentally regulate cell number or to eliminate cells that are potentially detrimental to the organism. The ma...
    • Apoptosis Modulation and Signaling, organism-specific biosystem (from WikiPathways)
      Apoptosis Modulation and Signaling, organism-specific biosystemApoptosis, or cell death program, can be activated by various mechanisms within the extrinsic and the intrinsic pathway. While activation of cell death receptors leads to the engagement of the extrin...
    • Apoptosis Modulation by HSP70, organism-specific biosystem (from WikiPathways)
      Apoptosis Modulation by HSP70, organism-specific biosystem
      Apoptosis Modulation by HSP70
    • BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members, organism-specific biosystem (from REACTOME)
      BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members, organism-specific biosystem
      BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members
    • Caspase cascade in apoptosis, organism-specific biosystem (from Pathway Interaction Database)
      Caspase cascade in apoptosis, organism-specific biosystem
      Caspase cascade in apoptosis
    • Ceramide signaling pathway, organism-specific biosystem (from Pathway Interaction Database)
      Ceramide signaling pathway, organism-specific biosystem
      Ceramide signaling pathway
    • DNA damage response, organism-specific biosystem (from WikiPathways)
      DNA damage response, organism-specific biosystemThis is the first pathway out of two pathways which deals with DNA damage response. It has two central gene products (ATM and ATR) which are connected to the sources of DNA damage (in blue). The two ...
    • Direct p53 effectors, organism-specific biosystem (from Pathway Interaction Database)
      Direct p53 effectors, organism-specific biosystem
      Direct p53 effectors
    • FAS (CD95) signaling pathway, organism-specific biosystem (from Pathway Interaction Database)
      FAS (CD95) signaling pathway, organism-specific biosystem
      FAS (CD95) signaling pathway
    • Gene Expression, organism-specific biosystem (from REACTOME)
      Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
    • Generic Transcription Pathway, organism-specific biosystem (from REACTOME)
      Generic Transcription Pathway, organism-specific biosystemOVERVIEW OF TRANSCRIPTION REGULATION: Detailed studies of gene transcription regulation in a wide variety of eukaryotic systems has revealed the general principles and mechanisms by which cell- or t...
    • HIV-1 Nef: Negative effector of Fas and TNF-alpha, organism-specific biosystem (from Pathway Interaction Database)
      HIV-1 Nef: Negative effector of Fas and TNF-alpha, organism-specific biosystem
      HIV-1 Nef: Negative effector of Fas and TNF-alpha
    • Integrated Breast Cancer Pathway, organism-specific biosystem (from WikiPathways)
      Integrated Breast Cancer Pathway, organism-specific biosystemThis pathway incorporates the most important proteins for Breast Cancer. The Rp score from the Connectivity-Maps (C-Maps) webserver was used to determine the rank of the most important proteins in Br...
    • Integrated Pancreatic Cancer Pathway, organism-specific biosystem (from WikiPathways)
      Integrated Pancreatic Cancer Pathway, organism-specific biosystemAn integrated pathway model which displays the protein-protein interactions (PPIs) among the relevant proteins for pancreatic cancer. This pathway is a collection of different mechanistic protein pat...
    • Intrinsic Pathway for Apoptosis, organism-specific biosystem (from REACTOME)
      Intrinsic Pathway for Apoptosis, organism-specific biosystemThe intrinsic (Bcl-2 inhibitable or mitochondrial) pathway of apoptosis functions in response to various types of intracellular stress including growth factor withdrawal, DNA damage, unfolding stress...
    • Natural killer cell mediated cytotoxicity, organism-specific biosystem (from KEGG)
      Natural killer cell mediated cytotoxicity, organism-specific biosystemNatural killer (NK) cells are lymphocytes of the innate immune system that are involved in early defenses against both allogeneic (nonself) cells and autologous cells undergoing various forms of stre...
    • Natural killer cell mediated cytotoxicity, conserved biosystem (from KEGG)
      Natural killer cell mediated cytotoxicity, conserved biosystemNatural killer (NK) cells are lymphocytes of the innate immune system that are involved in early defenses against both allogeneic (nonself) cells and autologous cells undergoing various forms of stre...
    • Non-alcoholic fatty liver disease (NAFLD), organism-specific biosystem (from KEGG)
      Non-alcoholic fatty liver disease (NAFLD), organism-specific biosystemNon-alcoholic fatty liver disease (NAFLD) represents a spectrum ranging from simple steatosis to more severe steatohepatitis with hepatic inflammation and fibrosis, known as nonalcoholic steatohepati...
    • Non-alcoholic fatty liver disease (NAFLD), conserved biosystem (from KEGG)
      Non-alcoholic fatty liver disease (NAFLD), conserved biosystemNon-alcoholic fatty liver disease (NAFLD) represents a spectrum ranging from simple steatosis to more severe steatohepatitis with hepatic inflammation and fibrosis, known as nonalcoholic steatohepati...
    • Pathways in cancer, organism-specific biosystem (from KEGG)
      Pathways in cancer, organism-specific biosystem
      Pathways in cancer
    • Programmed Cell Death, organism-specific biosystem (from REACTOME)
      Programmed Cell Death, organism-specific biosystemCell death is a fundamental cellular response that has a crucial role in shaping our bodies during development and in regulating tissue homeostasis by eliminating unwanted cells. There are a number o...
    • Sphingolipid signaling pathway, organism-specific biosystem (from KEGG)
      Sphingolipid signaling pathway, organism-specific biosystemSphingomyelin (SM) and its metabolic products are now known to have second messenger functions in a variety of cellular signaling pathways. Particularly, the sphingolipid metabolites, ceramide (Cer) ...
    • Sphingolipid signaling pathway, conserved biosystem (from KEGG)
      Sphingolipid signaling pathway, conserved biosystemSphingomyelin (SM) and its metabolic products are now known to have second messenger functions in a variety of cellular signaling pathways. Particularly, the sphingolipid metabolites, ceramide (Cer) ...
    • TP53 Regulates Transcription of Cell Death Genes, organism-specific biosystem (from REACTOME)
      TP53 Regulates Transcription of Cell Death Genes, organism-specific biosystemThe tumor suppressor TP53 (p53) exerts its tumor suppressive role in part by regulating transcription of a number of genes involved in cell death, mainly apoptotic cell death. The majority of apoptot...
    • TP53 Regulates Transcription of Genes Involved in Cytochrome C Release, organism-specific biosystem (from REACTOME)
      TP53 Regulates Transcription of Genes Involved in Cytochrome C Release, organism-specific biosystemApoptotic transcriptional targets of TP53 include genes that regulate the permeability of the mitochondrial membrane and/or cytochrome C release, such as BAX, BID, PMAIP1 (NOXA), BBC3 (PUMA) and prob...
    • TP53 network, organism-specific biosystem (from WikiPathways)
      TP53 network, organism-specific biosystemP53 is not a lonely genome guardian, it operates with the assistance of p73 and p63 within a complex network including distinct but complementary pathways. This protein family presents a high le...
    • Transcriptional Regulation by TP53, organism-specific biosystem (from REACTOME)
      Transcriptional Regulation by TP53, organism-specific biosystemThe tumor suppressor TP53 (encoded by the gene p53) is a transcription factor. Under stress conditions, it recognizes specific responsive DNA elements and thus regulates the transcription of many gen...
    • Tuberculosis, organism-specific biosystem (from KEGG)
      Tuberculosis, organism-specific biosystemTuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent...
    • Tuberculosis, conserved biosystem (from KEGG)
      Tuberculosis, conserved biosystemTuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent...
    • Viral myocarditis, organism-specific biosystem (from KEGG)
      Viral myocarditis, organism-specific biosystemMyocarditis is a cardiac disease associated with inflammation and injury of the myocardium. It results from various etiologies, both noninfectious and infectious, but coxsackievirus B3 (CVB3) is stil...
    • p53 signaling pathway, organism-specific biosystem (from KEGG)
      p53 signaling pathway, organism-specific biosystemp53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcriptional activator of p53-regulated ge...
    • p53 signaling pathway, conserved biosystem (from KEGG)
      p53 signaling pathway, conserved biosystemp53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcriptional activator of p53-regulated ge...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • MGC15319, MGC42355

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    death receptor binding TAS
    Traceable Author Statement
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    ubiquitin protein ligase binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    activation of cysteine-type endopeptidase activity involved in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    apoptotic mitochondrial changes TAS
    Traceable Author Statement
    more info
    PubMed 
    brain development IEA
    Inferred from Electronic Annotation
    more info
     
    establishment of protein localization to membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extrinsic apoptotic signaling pathway via death domain receptors TAS
    Traceable Author Statement
    more info
    PubMed 
    glial cell apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    hepatocyte apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    mitochondrial outer membrane permeabilization IEA
    Inferred from Electronic Annotation
    more info
     
    neuron apoptotic process TAS
    Traceable Author Statement
    more info
    PubMed 
    positive regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of extrinsic apoptotic signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of intrinsic apoptotic signaling pathway TAS
    Traceable Author Statement
    more info
     
    positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway TAS
    Traceable Author Statement
    more info
     
    positive regulation of protein homooligomerization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway TAS
    Traceable Author Statement
    more info
     
    positive regulation of protein oligomerization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of release of cytochrome c from mitochondria IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of release of cytochrome c from mitochondria IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein homooligomerization IEA
    Inferred from Electronic Annotation
    more info
     
    protein targeting to mitochondrion IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of G1/S transition of mitotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of apoptotic process TAS
    Traceable Author Statement
    more info
     
    regulation of cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    release of cytochrome c from mitochondria IDA
    Inferred from Direct Assay
    more info
    PubMed 
    response to estradiol IEA
    Inferred from Electronic Annotation
    more info
     
    signal transduction in response to DNA damage TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    cytosol TAS
    Traceable Author Statement
    more info
     
    extracellular exosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    integral component of mitochondrial membrane IEA
    Inferred from Electronic Annotation
    more info
     
    membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    mitochondrial outer membrane TAS
    Traceable Author Statement
    more info
     
    mitochondrion TAS
    Traceable Author Statement
    more info
    PubMed 
    Preferred Names
    BH3-interacting domain death agonist
    Names
    BID isoform ES(1b)
    BID isoform L(2)
    BID isoform Si6
    Human BID coding sequence
    apoptic death agonist
    desmocollin type 4
    p22 BID

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001196.3NP_001187.1  BH3-interacting domain death agonist isoform 2

      See identical proteins and their annotated locations for NP_001187.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) has an alternate 5' exon and uses a downstream in-frame start codon, as compared to variant 1. The encoded isoform 2 thus has a shorter N-terminus, as compared to isoform 1.
      Source sequence(s)
      AC006285, AK094795, BC036364, BM561391, BM842561
      Consensus CDS
      CCDS13748.1
      UniProtKB/Swiss-Prot
      P55957
      UniProtKB/TrEMBL
      A8ASI8, B3KT21
      Related
      ENSP00000480414, ENST00000622694
      Conserved Domains (1) summary
      pfam06393
      Location:1192
      BID; BH3 interacting domain (BID)
    2. NM_001244567.1NP_001231496.1  BH3-interacting domain death agonist isoform 2

      See identical proteins and their annotated locations for NP_001231496.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) has an alternate 5' exon and uses a downstream in-frame start codon, as compared to variant 1. The encoded isoform 2 thus has a shorter N-terminus, as compared to isoform 1.
      Source sequence(s)
      AC006285, AK094795, BC036364, EU678294
      Consensus CDS
      CCDS13748.1
      UniProtKB/Swiss-Prot
      P55957
      UniProtKB/TrEMBL
      A8ASI8, B3KT21
      Related
      ENSP00000449236, OTTHUMP00000241218, ENST00000551952, OTTHUMT00000404247
      Conserved Domains (1) summary
      pfam06393
      Location:1192
      BID; BH3 interacting domain (BID)
    3. NM_001244569.1NP_001231498.1  BH3-interacting domain death agonist isoform 3

      See identical proteins and their annotated locations for NP_001231498.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) has an alternate 5' exon and uses a downstream in-frame start codon, as compared to variant 1. The encoded isoform 3 thus has a shorter N-terminus, as compared to isoform 1.
      Source sequence(s)
      AC006285, AK094795, BC036364, CN277529, DA158889
      Consensus CDS
      CCDS13749.1
      UniProtKB/Swiss-Prot
      P55957
      UniProtKB/TrEMBL
      B2ZP79, B3KT21
      Related
      ENSP00000477773, ENST00000614949
      Conserved Domains (1) summary
      pfam06393
      Location:196
      BID; BH3 interacting domain (BID)
    4. NM_001244570.1NP_001231499.1  BH3-interacting domain death agonist isoform 3

      See identical proteins and their annotated locations for NP_001231499.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) has an alternate 5' exon and uses a downstream in-frame start codon, as compared to variant 1. The encoded isoform 3 thus has a shorter N-terminus, as compared to isoform 1.
      Source sequence(s)
      AC006285, AK094795, BC036364, DA007047, DA158889
      Consensus CDS
      CCDS13749.1
      UniProtKB/Swiss-Prot
      P55957
      UniProtKB/TrEMBL
      B2ZP79, B3KT21
      Related
      ENSP00000382667, OTTHUMP00000196197, ENST00000399765, OTTHUMT00000316181
      Conserved Domains (1) summary
      pfam06393
      Location:196
      BID; BH3 interacting domain (BID)
    5. NM_001244572.1NP_001231501.1  BH3-interacting domain death agonist isoform 3

      See identical proteins and their annotated locations for NP_001231501.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) lacks two alternate coding exons compared to variant 1, that causes a frameshift. This variant uses a downstream in-frame start-codon, so the encoded isoform 3 has a shorter N-terminus, as compared to isoform 1.
      Source sequence(s)
      AC006285, AK094795, BC036364, DA274603, DB167767
      Consensus CDS
      CCDS13749.1
      UniProtKB/Swiss-Prot
      P55957
      UniProtKB/TrEMBL
      B2ZP79, B3KT21
      Related
      ENSP00000483534, ENST00000615414
      Conserved Domains (1) summary
      pfam06393
      Location:196
      BID; BH3 interacting domain (BID)
    6. NM_197966.2NP_932070.1  BH3-interacting domain death agonist isoform 1

      See identical proteins and their annotated locations for NP_932070.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC006285, AF250233, AK094795, BC036364, DA274603
      Consensus CDS
      CCDS13747.1
      UniProtKB/Swiss-Prot
      P55957
      UniProtKB/TrEMBL
      B3KT21
      Related
      ENSP00000318822, OTTHUMP00000196195, ENST00000317361, OTTHUMT00000316179
      Conserved Domains (1) summary
      pfam06393
      Location:47238
      BID; BH3 interacting domain (BID)
    7. NM_197967.2NP_932071.1  BH3-interacting domain death agonist isoform 3

      See identical proteins and their annotated locations for NP_932071.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' region and uses a downstream start codon, as compared to variant 1. It encodes isoform 3 which has a shorter N-terminus, as compared to isoform 1.
      Source sequence(s)
      AC006285, AK094795, BC036364, DA158889
      Consensus CDS
      CCDS13749.1
      UniProtKB/Swiss-Prot
      P55957
      UniProtKB/TrEMBL
      B2ZP79, B3KT21
      Related
      ENSP00000382669, ENST00000399767
      Conserved Domains (1) summary
      pfam06393
      Location:196
      BID; BH3 interacting domain (BID)

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000022.11 Reference GRCh38.p7 Primary Assembly

      Range
      17734140..17774665 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017028906.1XP_016884395.1  

    Alternate CHM1_1.1

    Genomic

    1. NC_018933.2 Alternate CHM1_1.1

      Range
      18216448..18257021 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)